Allosteric Inhibition of Staphylococcus aureus D-Alanine:D-Alanine Ligase Revealed by Crystallographic Studies
Liu, Shenping, Chang, Jeanne S., Herberg, John T., Horng, Miao-Miao, Tomich, Paul K., Lin, Alice H., Marotti, Keith R.
Published in Proceedings of the National Academy of Sciences - PNAS (10.10.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (10.10.2006)
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Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors
Thaisrivongs, Suvit, Janakiraman, Musiri N, Chong, Kong-Teck, Tomich, Paul K, Dolak, Lester A, Turner, Steve R, Strohbach, Joseph W, Lynn, Janet C, Horng, Miao-Miao, Hinshaw, Roger R, Watenpaugh, Keith D
Published in Journal of medicinal chemistry (07.06.1996)
Published in Journal of medicinal chemistry (07.06.1996)
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Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class
Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Aristoff, Paul A, Johnson, Paul D, Skulnick, Harvey I, Dolak, Lester A, Seest, Eric P, Tomich, Paul K, Bohanon, Michael J, Horng, Miao-Miao, Lynn, Janet C, Chong, Kong-Teck, Hinshaw, Roger R, Watenpaugh, Keith D, Janakiraman, Musiri N, Thaisrivongs, Suvit
Published in Journal of medicinal chemistry (27.08.1998)
Published in Journal of medicinal chemistry (27.08.1998)
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The Ligand Affinity of Proteins Measured by Isothermal Denaturation Kinetics
Epps, Dennis E., Sarver, Ronald W., Rogers, Joseph M., Herberg, John T., Tomich, Paul K.
Published in Analytical biochemistry (01.05.2001)
Published in Analytical biochemistry (01.05.2001)
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3-arylpiperidines as potentiators of existing antibacterial agents
THORARENSEN, Atli, PRESLEY-BODNAR, Alice L, MAROTTI, Keith R, BOYLE, Timothy P, HECKAMAN, Charlotte L, BOHANON, Michael J, TOMICH, Paul K, ZURENKO, Gary E, SWEENEY, Michael T, YAGI, Betty H
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
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Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors
Thaisrivongs, Suvit, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Dolak, Lester A, Chong, Kong-Teck, Tomich, Che-Shen C, Tomasselli, Alfredo G, Turner, Steve R
Published in Journal of medicinal chemistry (01.09.1995)
Published in Journal of medicinal chemistry (01.09.1995)
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Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors
Thaisrivongs, Suvit, Romero, Donna L, Tommasi, Ruben A, Janakiraman, Musiri N, Strohbach, Joseph W, Turner, Steve R, Biles, Carolyn, Morge, Raymond R, Johnson, Paul D, Aristoff, Paul A, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Howe, W. Jeffrey, Finzel, Barry C, Watenpaugh, Keith D
Published in Journal of medicinal chemistry (08.11.1996)
Published in Journal of medicinal chemistry (08.11.1996)
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Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition
Thorarensen, Atli, Douglas, Jr, Martin R., Rohrer, Douglas C., Vosters, Anne F., Yem, Anthony W., Marshall, Vincent D., Lynn, Janet C., Bohanon, Michael J., Tomich, Paul K., Zurenko, Gary E., Sweeney, Michael T., Jensen, Randy M., Nielsen, James W., Seest, Eric P., Dolak, Lester A.
Published in Bioorganic & medicinal chemistry letters (04.06.2001)
Published in Bioorganic & medicinal chemistry letters (04.06.2001)
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Non-peptidic HIV protease inhibitors : C2-SYMMETRY-BASED design of bis-sulfonamide dihydropyrones
JANAKIRAMAN, M. N, WATENPAUGH, K. D, TOMICH, P. K, CHONG, K.-T, TURNER, S. R, TOMMASI, R. A, THAISRIVONGS, S, STROHBACH, J. W
Published in Bioorganic & medicinal chemistry letters (19.05.1998)
Published in Bioorganic & medicinal chemistry letters (19.05.1998)
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Use of Medium-Sized Cycloalkyl Rings To Enhance Secondary Binding: Discovery of a New Class of Human Immunodeficiency Virus (HIV) Protease Inhibitors
Romines, Karen R, Watenpaugh, Keith D, Tomich, Paul K, Howe, W. Jeffrey, Morris, Jeanette K, Lovasz, Kristine D, Mulichak, Anne M, Finzel, Barry C, Lynn, Janet C
Published in Journal of medicinal chemistry (01.05.1995)
Published in Journal of medicinal chemistry (01.05.1995)
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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors from a Cyclooctylpyranone Lead Structure
Romines, Karen R, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Lovasz, Kristine D, Morris, Jeanette K, Janakiraman, Musiri N, Lynn, Janet C, Horng, Miao-Miao
Published in Journal of medicinal chemistry (01.10.1995)
Published in Journal of medicinal chemistry (01.10.1995)
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Cycloalkylpyranones and Cycloalkyldihydropyrones as HIV Protease Inhibitors: Exploring the Impact of Ring Size on Structure−Activity Relationships
Romines, Karen R, Morris, Jeanette K, Howe, W. Jeffrey, Tomich, Paul K, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Anderson, David J, Strohbach, Joseph W, Turner, Steve R, Mizsak, Steve A
Published in Journal of medicinal chemistry (27.09.1996)
Published in Journal of medicinal chemistry (27.09.1996)
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Evidence for a Complex Regulating the in Vivo Activities of Early Enzymes Induced by Bacteriophage T4
Tomich, P K, Chiu, C S, Wovcha, M G, Greenberg, G R
Published in The Journal of biological chemistry (10.12.1974)
Published in The Journal of biological chemistry (10.12.1974)
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Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors
Thaisrivongs, Suvit, Tomich, Paul K, Watenpaugh, Keith D, Chong, Kong-Teck, Howe, W. Jeffrey, Yang, Chih-Ping, Strohbach, Joseph W, Turner, Steve R, McGrath, James P
Published in Journal of medicinal chemistry (01.09.1994)
Published in Journal of medicinal chemistry (01.09.1994)
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Journal Article
Structure-Based Design of HIV Protease Inhibitors: Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors
Thaisrivongs, Suvit, Skulnick, Harvey I, Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Johnson, Paul D, Aristoff, Paul A, Judge, Thomas M, Gammill, Ronald B, Morris, Jeanette K, Romines, Karen R, Chrusciel, Robert A, Hinshaw, Roger R, Chong, Kong-Teck, Tarpley, W. Gary, Poppe, Susan M, Slade, David E, Lynn, Janet C, Horng, Miao-Miao, Tomich, Paul K, Seest, Eric P, Dolak, Lester A, Howe, W. Jeffrey, Howard, Gina M, Schwende, Francis J, Toth, Lisa N, Padbury, Guy E, Wilson, Grace J, Shiou, Lihua, Zipp, Gail L, Wilkinson, Karen F, Rush, Bob D, Ruwart, Mary J, Koeplinger, Kenneth A, Zhao, Zhiyang, Cole, Serena, Zaya, Renee M, Kakuk, Thomas J, Janakiraman, Musiri N, Watenpaugh, Keith D
Published in Journal of medicinal chemistry (25.10.1996)
Published in Journal of medicinal chemistry (25.10.1996)
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Journal Article
Non-peptidic HIV protease inhibitors: C 2-symmetry-based design of bis-sulfonamide dihydropyrones
Janakiraman, Musiri N., Watenpaugh, Keith D., Tomich, Paul K., Chong, Kong-Teck, Turner, Steve R., Tommasi, Ruben A., Thaisrivongs, Suvit, Strohbach, Joseph W.
Published in Bioorganic & medicinal chemistry letters (19.05.1998)
Published in Bioorganic & medicinal chemistry letters (19.05.1998)
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Journal Article
Structure-Based Design of Sulfonamide-Substituted Non-Peptidic HIV Protease Inhibitors
Skulnick, Harvey I, Johnson, Paul D, Howe, W. Jeffrey, Tomich, Paul K, Chong, Kong-Teck, Watenpaugh, Keith D, Janakiraman, Musiri N, Dolak, Lester A, McGrath, James P
Published in Journal of medicinal chemistry (01.12.1995)
Published in Journal of medicinal chemistry (01.12.1995)
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Corrigendum to “Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition” [Bioorg. Med. Chem. Lett. 11 (2001) 1355]
Thorarensen, Atli, Deibel, Martin R., Rohrer, Douglas C., Vosters, Anne F., Yem, Anthony W., Marshall, Vincent D., Lynn, Janet C., Bohanon, Michael J., Tomich, Paul K., Zurenko, Gary E., Sweeney, Michael T., Jensen, Randy M., Nielsen, James W., Seest, Eric P., Dolak, Lester A.
Published in Bioorganic & medicinal chemistry letters (01.08.2001)
Published in Bioorganic & medicinal chemistry letters (01.08.2001)
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