A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency
Zhou, Qing, Lee, Geun-Shik, Brady, Jillian, Datta, Shrimati, Katan, Matilda, Sheikh, Afzal, Martins, Marta S, Bunney, Tom D, Santich, Brian H, Moir, Susan, Kuhns, Douglas B, Long Priel, Debra A, Ombrello, Amanda, Stone, Deborah, Ombrello, Michael J, Khan, Javed, Milner, Joshua D, Kastner, Daniel L, Aksentijevich, Ivona
Published in American journal of human genetics (05.10.2012)
Published in American journal of human genetics (05.10.2012)
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Journal Article
Targeting the Src Pathway Enhances the Efficacy of Selective FGFR Inhibitors in Urothelial Cancers with FGFR3 Alterations
Lima, Nadia Carvalho, Atkinson, Eliza, Bunney, Tom D, Katan, Matilda, Huang, Paul H
Published in International journal of molecular sciences (01.05.2020)
Published in International journal of molecular sciences (01.05.2020)
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Journal Article
Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation
Bunney, Tom D., Esposito, Diego, Mas-Droux, Corine, Lamber, Ekatarina, Baxendale, Rhona W., Martins, Marta, Cole, Ambrose, Svergun, Dmitri, Driscoll, Paul C., Katan, Matilda
Published in Structure (London) (05.12.2012)
Published in Structure (London) (05.12.2012)
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Journal Article
Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes
Liu, Yang, Bunney, Tom D., Khosa, Sakshi, Macé, Kévin, Beckenbauer, Katharina, Askwith, Trevor, Maslen, Sarah, Stubbs, Christopher, de Oliveira, Taiana M., Sader, Kasim, Skehel, Mark, Gavin, Anne-Claude, Phillips, Christopher, Katan, Matilda
Published in EBioMedicine (01.01.2020)
Published in EBioMedicine (01.01.2020)
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Journal Article
14‐3‐3 adaptor proteins are intermediates in ABA signal transduction during barley seed germination
Schoonheim, Peter J., Sinnige, Mark P., Casaretto, Jose A., Veiga, Helena, Bunney, Tom D., Quatrano, Ralph S., de Boer, Albertus H.
Published in The Plant journal : for cell and molecular biology (01.01.2007)
Published in The Plant journal : for cell and molecular biology (01.01.2007)
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Journal Article
The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study
Bunney, Tom D., Wan, Shunzhou, Thiyagarajan, Nethaji, Sutto, Ludovico, Williams, Sarah V., Ashford, Paul, Koss, Hans, Knowles, Margaret A., Gervasio, Francesco L., Coveney, Peter V., Katan, Matilda
Published in EBioMedicine (01.03.2015)
Published in EBioMedicine (01.03.2015)
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Journal Article
PLC regulation: emerging pictures for molecular mechanisms
Bunney, Tom D., Katan, Matilda
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.02.2011)
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.02.2011)
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Journal Article
Dysfunction of phospholipase Cγ in immune disorders and cancer
Koss, Hans, Bunney, Tom D., Behjati, Sam, Katan, Matilda
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.12.2014)
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.12.2014)
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Journal Article
Membrane Environment Exerts an Important Influence on Rac-Mediated Activation of Phospholipase Cγ2
Everett, Katy L., Buehler, Anja, Bunney, Tom D., Margineanu, Anca, Baxendale, Rhona W., Vatter, Petra, Retlich, Michael, Walliser, Claudia, Manning, Hugh B., Neil, Mark A. A., Dunsby, Christopher, French, Paul M. W., Gierschik, Peter, Katan, Matilda
Published in Molecular and Cellular Biology (01.03.2011)
Published in Molecular and Cellular Biology (01.03.2011)
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Journal Article
Characterization of Interactions of Adapter Protein RAPL/Nore1B with RAP GTPases and Their Role in T Cell Migration
Miertzschke, Mandy, Stanley, Paula, Bunney, Tom D., Rodrigues-Lima, Fernando, Hogg, Nancy, Katan, Matilda
Published in The Journal of biological chemistry (19.10.2007)
Published in The Journal of biological chemistry (19.10.2007)
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Journal Article
Characterisation of molecular mechanisms for PLCγ2 disease-linked variants
Bunney, Tom D., Kampyli, Charis, Gregory, Ashley, Katan, Matilda
Published in Advances in biological regulation (01.12.2024)
Published in Advances in biological regulation (01.12.2024)
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Journal Article
A frequent PLCγ1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells
Prawiro, Christy, Bunney, Tom D., Kampyli, Charis, Yaguchi, Hiroko, Katan, Matilda, Bangham, Charles R.M.
Published in Biochimica et biophysica acta. Molecular basis of disease (01.02.2023)
Published in Biochimica et biophysica acta. Molecular basis of disease (01.02.2023)
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Journal Article
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
Gong, Grace Q., Bilanges, Benoit, Allsop, Ben, Masson, Glenn R., Roberton, Victoria, Askwith, Trevor, Oxenford, Sally, Madsen, Ralitsa R., Conduit, Sarah E., Bellini, Dom, Fitzek, Martina, Collier, Matt, Najam, Osman, He, Zhenhe, Wahab, Ben, McLaughlin, Stephen H., Chan, A. W. Edith, Feierberg, Isabella, Madin, Andrew, Morelli, Daniele, Bhamra, Amandeep, Vinciauskaite, Vanesa, Anderson, Karen E., Surinova, Silvia, Pinotsis, Nikos, Lopez-Guadamillas, Elena, Wilcox, Matthew, Hooper, Alice, Patel, Chandni, Whitehead, Maria A., Bunney, Tom D., Stephens, Len R., Hawkins, Phillip T., Katan, Matilda, Yellon, Derek M., Davidson, Sean M., Smith, David M., Phillips, James B., Angell, Richard, Williams, Roger L., Vanhaesebroeck, Bart
Published in Nature (London) (01.06.2023)
Published in Nature (London) (01.06.2023)
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Journal Article