Human Huntington’s Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation
Mehta, Shagun R., Tom, Colton M., Wang, Yizhou, Bresee, Catherine, Rushton, David, Mathkar, Pranav P., Tang, Jie, Mattis, Virginia B.
Published in Cell reports (Cambridge) (23.10.2018)
Published in Cell reports (Cambridge) (23.10.2018)
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Journal Article
Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support
Garcia, Veronica J, Rushton, David J, Tom, Colton M, Allen, Nicholas D, Kemp, Paul J, Svendsen, Clive N, Mattis, Virginia B
Published in Frontiers in neuroscience (28.06.2019)
Published in Frontiers in neuroscience (28.06.2019)
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Journal Article
The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons
Machiela, Emily, Jeloka, Ritika, Caron, Nicholas S., Mehta, Shagun, Schmidt, Mandi E., Baddeley, Helen J. E., Tom, Colton M., Polturi, Nalini, Xie, Yuanyun, Mattis, Virginia B., Hayden, Michael R., Southwell, Amber L.
Published in Frontiers in aging neuroscience (18.09.2020)
Published in Frontiers in aging neuroscience (18.09.2020)
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Journal Article
Optimization of trans -Splicing for Huntington's Disease RNA Therapy
Rindt, Hansjörg, Tom, Colton M, Lorson, Christian L, Mattis, Virginia B
Published in Frontiers in neuroscience (10.10.2017)
Published in Frontiers in neuroscience (10.10.2017)
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Journal Article
Inducible Expression of GDNF in Transplanted iPSC-Derived Neural Progenitor Cells
Akhtar, Aslam Abbasi, Gowing, Genevieve, Kobritz, Naomi, Savinoff, Steve E., Garcia, Leslie, Saxon, David, Cho, Noell, Kim, Gibum, Tom, Colton M., Park, Hannah, Lawless, George, Shelley, Brandon C., Mattis, Virginia B., Breunig, Joshua J., Svendsen, Clive N.
Published in Stem cell reports (05.06.2018)
Published in Stem cell reports (05.06.2018)
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Journal Article
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
Lim, Ryan G, Salazar, Lisa L, Wilton, Daniel K, King, Alvin R, Stocksdale, Jennifer T, Sharifabad, Delaram, Lau, Alice L, Stevens, Beth, Reidling, Jack C, Winokur, Sara T, Casale, Malcolm S, Thompson, Leslie M, Pardo, Mónica, Díaz-Barriga, A Gerardo García, Straccia, Marco, Sanders, Phil, Alberch, Jordi, Canals, Josep M, Kaye, Julia A, Dunlap, Mariah, Jo, Lisa, May, Hanna, Mount, Elliot, Anderson-Bergman, Cliff, Haston, Kelly, Finkbeiner, Steven, Kedaigle, Amanda J, Gipson, Theresa A, Yildirim, Ferah, Ng, Christopher W, Milani, Pamela, Housman, David E, Fraenkel, Ernest, Allen, Nicholas D, Kemp, Paul J, Atwal, Ranjit Singh, Biagioli, Marta, Gusella, James F, MacDonald, Marcy E, Akimov, Sergey S, Arbez, Nicolas, Stewart, Jacqueline, Ross, Christopher A, Mattis, Virginia B, Tom, Colton M, Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Svendsen, Clive N
Published in Nature neuroscience (01.05.2017)
Published in Nature neuroscience (01.05.2017)
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Journal Article
Bioenergetic deficits in Huntington's disease iPSC-derived neural cells and rescue with glycolytic metabolites
Kedaigle, Amanda J, Fraenkel, Ernest, Atwal, Ranjit S, Wu, Min, Gusella, James F, MacDonald, Marcy E, Kaye, Julia A, Finkbeiner, Steven, Mattis, Virginia B, Tom, Colton M, Svendsen, Clive, King, Alvin R, Chen, Yumay, Stocksdale, Jennifer T, Lim, Ryan G, Casale, Malcolm, Wang, Ping H, Thompson, Leslie M, Akimov, Sergey S, Ratovitski, Tamara, Arbez, Nicolas, Ross, Christopher A
Published in Human molecular genetics (21.07.2020)
Published in Human molecular genetics (21.07.2020)
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Survival of iPSC-derived grafts within the striatum of immunodeficient mice: Importance of developmental stage of both transplant and host recipient
Tom, Colton M., Younesi, Shahab, Meer, Elana, Bresee, Catherine, Godoy, Marlesa, Mattis, Virginia B.
Published in Experimental neurology (01.11.2017)
Published in Experimental neurology (01.11.2017)
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