PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation
Damasceno, Luis Eduardo Alves, Prado, Douglas Silva, Veras, Flavio Protasio, Fonseca, Miriam M, Toller-Kawahisa, Juliana E, Rosa, Marcos Henrique, Públio, Gabriel Azevedo, Martins, Timna Varela, Ramalho, Fernando S, Waisman, Ari, Cunha, Fernando Queiroz, Cunha, Thiago Mattar, Alves-Filho, José Carlos
Published in The Journal of experimental medicine (05.10.2020)
Published in The Journal of experimental medicine (05.10.2020)
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Neutrophil Extracellular Traps Effectively Control Acute Chikungunya Virus Infection
Hiroki, Carlos H, Toller-Kawahisa, Juliana E, Fumagalli, Marcilio J, Colon, David F, Figueiredo, Luiz T M, Fonseca, Bendito A L D, Franca, Rafael F O, Cunha, Fernando Q
Published in Frontiers in immunology (31.01.2020)
Published in Frontiers in immunology (31.01.2020)
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MEK5/ERK5 signaling mediates IL‐4‐induced M2 macrophage differentiation through regulation of c‐Myc expression
Luiz, João Paulo M., Toller‐Kawahisa, Juliana E., Viacava, Paula R., Nascimento, Daniele C., Pereira, Priscilla T., Saraiva, André L., Prado, Douglas S., LeBert, Marc, Giurisato, Emanuele, Tournier, Cathy, Cunha, Thiago M., Cunha, Fernando Q., Quesniaux, Valerie, Ryffel, Bernhard, Alves‐Filho, José C.
Published in Journal of leukocyte biology (01.10.2020)
Published in Journal of leukocyte biology (01.10.2020)
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SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology
Veras, Flavio Protasio, Pontelli, Marjorie Cornejo, Silva, Camila Meirelles, Toller-Kawahisa, Juliana E, de Lima, Mikhael, Nascimento, Daniele Carvalho, Schneider, Ayda Henriques, Caetité, Diego, Tavares, Lucas Alves, Paiva, Isadora M, Rosales, Roberta, Colón, David, Martins, Ronaldo, Castro, Italo Araujo, Almeida, Glaucia M, Lopes, Maria Isabel Fernandes, Benatti, Maíra Nilson, Bonjorno, Letícia Pastorelli, Giannini, Marcela Cavichioli, Luppino-Assad, Rodrigo, Almeida, Sérgio Luna, Vilar, Fernando, Santana, Rodrigo, Bollela, Valdes R, Auxiliadora-Martins, Maria, Borges, Marcos, Miranda, Carlos Henrique, Pazin-Filho, Antônio, da Silva, Luis Lamberti P, Cunha, Larissa Dias, Zamboni, Dario S, Dal-Pizzol, Felipe, Leiria, Luiz O, Siyuan, Li, Batah, Sabrina, Fabro, Alexandre, Mauad, Thais, Dolhnikoff, Marisa, Duarte-Neto, Amaro, Saldiva, Paulo, Cunha, Thiago Mattar, Alves-Filho, José Carlos, Arruda, Eurico, Louzada-Junior, Paulo, Oliveira, Renê Donizeti, Cunha, Fernando Queiroz
Published in The Journal of experimental medicine (07.12.2020)
Published in The Journal of experimental medicine (07.12.2020)
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Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
Hooftman, Alexander, Peace, Christian G., Ryan, Dylan G., Day, Emily A., Yang, Ming, McGettrick, Anne F., Yin, Maureen, Montano, Erica N., Huo, Lihong, Toller-Kawahisa, Juliana E., Zecchini, Vincent, Ryan, Tristram A. J., Bolado-Carrancio, Alfonso, Casey, Alva M., Prag, Hiran A., Costa, Ana S. H., De Los Santos, Gabriela, Ishimori, Mariko, Wallace, Daniel J., Venuturupalli, Swamy, Nikitopoulou, Efterpi, Frizzell, Norma, Johansson, Cecilia, Von Kriegsheim, Alexander, Murphy, Michael P., Jefferies, Caroline, Frezza, Christian, O’Neill, Luke A. J.
Published in Nature (London) (16.03.2023)
Published in Nature (London) (16.03.2023)
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Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
Ryan, Tristram A. J., Hooftman, Alexander, Rehill, Aisling M., Johansen, Matt D., Brien, Eóin C. O’, Toller-Kawahisa, Juliana E., Wilk, Mieszko M., Day, Emily A., Weiss, Hauke J., Sarvari, Pourya, Vozza, Emilio G., Schramm, Fabian, Peace, Christian G., Zotta, Alessia, Miemczyk, Stefan, Nalkurthi, Christina, Hansbro, Nicole G., McManus, Gavin, O’Doherty, Laura, Gargan, Siobhan, Long, Aideen, Dunne, Jean, Cheallaigh, Clíona Ní, Conlon, Niall, Carty, Michael, Fallon, Padraic G., Mills, Kingston H. G., Creagh, Emma M., Donnell, James S. O’, Hertzog, Paul J., Hansbro, Philip M., McLoughlin, Rachel M., Wygrecka, Małgorzata, Preston, Roger J. S., Zasłona, Zbigniew, O’Neill, Luke A. J.
Published in Nature communications (14.06.2023)
Published in Nature communications (14.06.2023)
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Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation
McArthur, Simon, Juban, Gaëtan, Gobbetti, Thomas, Desgeorges, Thibaut, Theret, Marine, Gondin, Julien, Toller-Kawahisa, Juliana E, Reutelingsperger, Chris P, Chazaud, Bénédicte, Perretti, Mauro, Mounier, Rémi
Published in The Journal of clinical investigation (01.03.2020)
Published in The Journal of clinical investigation (01.03.2020)
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Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation
Veras, Flávio P., Publio, Gabriel A., Melo, Bruno M., Prado, Douglas S., Norbiato, Thainá, Cecilio, Nerry T., Hiroki, Carlos, Damasceno, Luis Eduardo A., Jung, Rebecca, Toller-Kawahisa, Juliana E., Martins, Timna V., Assunção, Stella F., Lima, Diogenes, Alves, Marcia G., Vieira, Gabriel V., Tavares, Lucas A., Alves-Rezende, Ana L.R., Karbach, Susanne H., Nakaya, Helder I., Cunha, Thiago M., Souza, Cacilda S., Cunha, Fernando Q., Sales, Katiuchia U., Waisman, Ari, Alves-Filho, José C.
Published in Cell reports (Cambridge) (27.12.2022)
Published in Cell reports (Cambridge) (27.12.2022)
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Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
Ryan, Tristram A. J., Hooftman, Alexander, Rehill, Aisling M., Johansen, Matt D., O’ Brien, Eóin C., Toller-Kawahisa, Juliana E., Wilk, Mieszko M., Day, Emily A., Weiss, Hauke J., Sarvari, Pourya, Vozza, Emilio G., Schramm, Fabian, Peace, Christian G., Zotta, Alessia, Miemczyk, Stefan, Nalkurthi, Christina, Hansbro, Nicole G., McManus, Gavin, O’Doherty, Laura, Gargan, Siobhan, Long, Aideen, Dunne, Jean, Cheallaigh, Clíona Ní, Conlon, Niall, Carty, Michael, Fallon, Padraic G., Mills, Kingston H. G., Creagh, Emma M., O’ Donnell, James S., Hertzog, Paul J., Hansbro, Philip M., McLoughlin, Rachel M., Wygrecka, Małgorzata, Preston, Roger J. S., Zasłona, Zbigniew, O’Neill, Luke A. J.
Published in Nature communications (20.07.2023)
Published in Nature communications (20.07.2023)
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Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase
O'Carroll, Shane M, Peace, Christian G, Toller-Kawahisa, Juliana E, Min, Yukun, Hooftman, Alexander, Charki, Sara, Kehoe, Louise, O'Sullivan, Maureen J, Zoller, Aline, Mcgettrick, Anne F, Day, Emily A, Simarro, Maria, Armstrong, Neali, Annes, Justin P, O'Neill, Luke A J
Published in Nature metabolism (15.10.2024)
Published in Nature metabolism (15.10.2024)
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The DNA sensor AIM2 mediates psoriasiform inflammation by inducing type 3 immunity
Varela Martins, Timna, Silva de Melo, Bruno Marcel, Toller-Kawahisa, Juliana E, Silva, Gabriel Vl, Anibal-Silva, Conceição E, Paiva, Isadora M, Publio, Gabriel A, Rosa, Marcos Henrique, da Silva Souza, Cacilda, Zamboni, Dario S, Cunha, Fernando Q, Cunha, Thiago M, Ryffel, Bernhard, Riteau, Nicolas, Alves-Filho, José C
Published in JCI insight (01.10.2024)
Published in JCI insight (01.10.2024)
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Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation
Silva, Camila Meirelles S., Wanderley, Carlos Wagner S., Veras, Flavio P., Sonego, Fabiane, Nascimento, Daniele C., Gonçalves, Augusto V., Martins, Timna V., Cólon, David F., Borges, Vanessa F., Brauer, Verônica S., Damasceno, Luis Eduardo A., Silva, Katiussia P., Toller-Kawahisa, Juliana E., Batah, Sabrina S., Souza, Ana Letícia J., Monteiro, Valter S., Oliveira, Antônio Edson R., Donate, Paula B., Zoppi, Daniel, Borges, Marcos C., Almeida, Fausto, Nakaya, Helder I., Fabro, Alexandre T., Cunha, Thiago M., Alves-Filho, José Carlos, Zamboni, Dario S., Cunha, Fernando Q.
Published in Blood (23.12.2021)
Published in Blood (23.12.2021)
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Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation
Mcarthur, Simon, Juban, Gaëtan, Gobbetti, Thomas, Desgeorges, Thibaut, Theret, Marine, Gondin, Julien, Toller-Kawahisa, Juliana E, Reutelingsperger, Chris P, Chazaud, Bénédicte, Perretti, Mauro, Mounier, Rémi
Published in The Journal of clinical investigation (01.03.2020)
Published in The Journal of clinical investigation (01.03.2020)
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SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients
Pontelli, Marjorie C, Castro, Ítalo A, Martins, Ronaldo B, La Serra, Leonardo, Veras, Flávio P, Nascimento, Daniele C, Silva, Camila M, Cardoso, Ricardo S, Rosales, Roberta, Gomes, Rogério, Lima, Thais M, Souza, Juliano P, Vitti, Brenda C, Caetité, Diego B, de Lima, Mikhael H F, Stumpf, Spencer D, Thompson, Cassandra E, Bloyet, Louis-Marie, Toller-Kawahisa, Juliana E, Giannini, Marcela C, Bonjorno, Letícia P, Lopes, Maria I F, Batah, Sabrina S, Siyuan, Li, Luppino-Assad, Rodrigo, Almeida, Sergio C L, Oliveira, Fabiola R, Benatti, Maíra N, Pontes, Lorena L F, Santana, Rodrigo C, Vilar, Fernando C, Auxiliadora-Martins, Maria, Shi, Pei-Yong, Cunha, Thiago M, Calado, Rodrigo T, Alves-Filho, José C, Zamboni, Dario S, Fabro, Alexandre T, Louzada-Junior, Paulo, Oliveira, Rene D R, Whelan, Sean P J, Cunha, Fernando Q, Arruda, Eurico
Published in Journal of molecular cell biology (17.08.2022)
Published in Journal of molecular cell biology (17.08.2022)
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Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells
Salina, Ana C G, Dos-Santos, Douglas, Rodrigues, Tamara S, Fortes-Rocha, Marlon, Freitas-Filho, Edismauro G, Alzamora-Terrel, Daniel L, Castro, Icaro M S, Fraga da Silva, Thais F C, de Lima, Mikhael H F, Nascimento, Daniele C, Silva, Camila M, Toller-Kawahisa, Juliana E, Becerra, Amanda, Oliveira, Samuel, Caetité, Diego B, Almeida, Leticia, Ishimoto, Adriene Y, Lima, Thais M, Martins, Ronaldo B, Veras, Flavio, do Amaral, Natália B, Giannini, Marcela C, Bonjorno, Letícia P, Lopes, Maria I F, Benatti, Maira N, Batah, Sabrina S, Santana, Rodrigo C, Vilar, Fernando C, Martins, Maria A, Assad, Rodrigo L, de Almeida, Sergio C L, de Oliveira, Fabiola R, Arruda Neto, Eurico, Cunha, Thiago M, Alves-Filho, José C, Bonato, Vania L D, Cunha, Fernando Q, Fabro, Alexandre T, Nakaya, Helder I, Zamboni, Dario S, Louzada-Junior, Paulo, Oliveira, Rene D R, Cunha, Larissa D
Published in eLife (06.06.2022)
Published in eLife (06.06.2022)
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