Mouse α-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt
Wang, Qingxia, Yang, Yilin, Luo, Gan, Zhou, Yang, Tolbert, William D, Pazgier, Marzena, Liao, Chongbing, Lu, Wuyuan
Published in Infection and immunity (24.01.2023)
Published in Infection and immunity (24.01.2023)
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Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region
Tolbert, William D., Gohain, Neelakshi, Alsahafi, Nirmin, Van, Verna, Orlandi, Chiara, Ding, Shilei, Martin, Loïc, Finzi, Andrés, Lewis, George K., Ray, Krishanu, Pazgier, Marzena
Published in Structure (London) (07.11.2017)
Published in Structure (London) (07.11.2017)
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Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern
Li, Wenwei, Chen, Yaozong, Prévost, Jérémie, Ullah, Irfan, Lu, Maolin, Gong, Shang Yu, Tauzin, Alexandra, Gasser, Romain, Vézina, Dani, Anand, Sai Priya, Goyette, Guillaume, Chaterjee, Debashree, Ding, Shilei, Tolbert, William D., Grunst, Michael W., Bo, Yuxia, Zhang, Shijian, Richard, Jonathan, Zhou, Fei, Huang, Rick K., Esser, Lothar, Zeher, Allison, Côté, Marceline, Kumar, Priti, Sodroski, Joseph, Xia, Di, Uchil, Pradeep D., Pazgier, Marzena, Finzi, Andrés, Mothes, Walther
Published in Cell reports (Cambridge) (11.01.2022)
Published in Cell reports (Cambridge) (11.01.2022)
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A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection
Beaudoin-Bussières, Guillaume, Chen, Yaozong, Ullah, Irfan, Prévost, Jérémie, Tolbert, William D., Symmes, Kelly, Ding, Shilei, Benlarbi, Mehdi, Gong, Shang Yu, Tauzin, Alexandra, Gasser, Romain, Chatterjee, Debashree, Vézina, Dani, Goyette, Guillaume, Richard, Jonathan, Zhou, Fei, Stamatatos, Leonidas, McGuire, Andrew T., Charest, Hughes, Roger, Michel, Pozharski, Edwin, Kumar, Priti, Mothes, Walther, Uchil, Pradeep D., Pazgier, Marzena, Finzi, Andrés
Published in Cell reports (Cambridge) (15.02.2022)
Published in Cell reports (Cambridge) (15.02.2022)
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Identification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral Responses
Sajadi, Mohammad Mohseni, Dashti, Amir, Rikhtegaran Tehrani, Zahra, Tolbert, William D., Seaman, Michael S., Ouyang, Xin, Gohain, Neelakshi, Pazgier, Marzena, Kim, Dongkyoon, Cavet, Guy, Yared, Jean, Redfield, Robert R., Lewis, George K., DeVico, Anthony L.
Published in Cell (14.06.2018)
Published in Cell (14.06.2018)
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CD4 Incorporation into HIV-1 Viral Particles Exposes Envelope Epitopes Recognized by CD4-Induced Antibodies
Ding, Shilei, Gasser, Romain, Gendron-Lepage, Gabrielle, Medjahed, Halima, Tolbert, William D, Sodroski, Joseph, Pazgier, Marzena, Finzi, Andrés
Published in Journal of virology (15.11.2019)
Published in Journal of virology (15.11.2019)
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Journal Article
The HIV-1 Antisense Protein ASP Is a Transmembrane Protein of the Cell Surface and an Integral Protein of the Viral Envelope
Affram, Yvonne, Zapata, Juan C, Gholizadeh, Zahra, Tolbert, William D, Zhou, Wei, Iglesias-Ussel, Maria D, Pazgier, Marzena, Ray, Krishanu, Latinovic, Olga S, Romerio, Fabio
Published in Journal of virology (01.11.2019)
Published in Journal of virology (01.11.2019)
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Journal Article
Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region
Tolbert, William D., Gohain, Neelakshi, Veillette, Maxime, Chapleau, Jean-Philippe, Orlandi, Chiara, Visciano, Maria L., Ebadi, Maryam, DeVico, Anthony L., Fouts, Timothy R., Finzi, Andrés, Lewis, George K., Pazgier, Marzena
Published in Structure (London) (03.05.2016)
Published in Structure (London) (03.05.2016)
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Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity
Tolbert, William D, Sherburn, Rebekah T, Van, Verna, Pazgier, Marzena
Published in Viruses (16.01.2019)
Published in Viruses (16.01.2019)
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Journal Article
An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity
Alsahafi, Nirmin, Bakouche, Nordine, Kazemi, Mohsen, Richard, Jonathan, Ding, Shilei, Bhattacharyya, Sudipta, Das, Durba, Anand, Sai Priya, Prévost, Jérémie, Tolbert, William D., Lu, Hong, Medjahed, Halima, Gendron-Lepage, Gabrielle, Ortega Delgado, Gloria Gabrielle, Kirk, Sharon, Melillo, Bruno, Mothes, Walther, Sodroski, Joseph, Smith, Amos B., Kaufmann, Daniel E., Wu, Xueling, Pazgier, Marzena, Rouiller, Isabelle, Finzi, Andrés, Munro, James B.
Published in Cell host & microbe (10.04.2019)
Published in Cell host & microbe (10.04.2019)
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Two Families of Env Antibodies Efficiently Engage Fc-Gamma Receptors and Eliminate HIV-1-Infected Cells
Anand, Sai Priya, Prévost, Jérémie, Baril, Sophie, Richard, Jonathan, Medjahed, Halima, Chapleau, Jean-Philippe, Tolbert, William D, Kirk, Sharon, Smith, 3rd, Amos B, Wines, Bruce D, Kent, Stephen J, Hogarth, P Mark, Parsons, Matthew S, Pazgier, Marzena, Finzi, Andrés
Published in Journal of virology (01.02.2019)
Published in Journal of virology (01.02.2019)
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Journal Article
Antibody-Induced Internalization of HIV-1 Env Proteins Limits Surface Expression of the Closed Conformation of Env
Anand, Sai Priya, Grover, Jonathan R, Tolbert, William D, Prévost, Jérémie, Richard, Jonathan, Ding, Shilei, Baril, Sophie, Medjahed, Halima, Evans, David T, Pazgier, Marzena, Mothes, Walther, Finzi, Andrés
Published in Journal of virology (01.06.2019)
Published in Journal of virology (01.06.2019)
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Journal Article
Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques
Tolbert, William D, Gohain, Neelakshi, Kremer, Paul G, Hederman, Andrew P, Nguyen, Dung N, Van, Verna, Sherburn, Rebekah, Lewis, George K, Finzi, Andrés, Pollara, Justin, Ackerman, Margaret E, Barb, Adam W, Pazgier, Marzena
Published in Frontiers in immunology (05.09.2022)
Published in Frontiers in immunology (05.09.2022)
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Journal Article
Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1
Gohain, Neelakshi, Tolbert, William D, Acharya, Priyamvada, Yu, Lei, Liu, Tongyun, Zhao, Pingsen, Orlandi, Chiara, Visciano, Maria L, Kamin-Lewis, Roberta, Sajadi, Mohammad M, Martin, Loïc, Robinson, James E, Kwong, Peter D, DeVico, Anthony L, Ray, Krishanu, Lewis, George K, Pazgier, Marzena
Published in Journal of virology (01.09.2015)
Published in Journal of virology (01.09.2015)
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Journal Article
Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120
Richard, Jonathan, Prévost, Jérémie, Bourassa, Catherine, Brassard, Nathalie, Boutin, Marianne, Benlarbi, Mehdi, Goyette, Guillaume, Medjahed, Halima, Gendron-Lepage, Gabrielle, Gaudette, Fleur, Chen, Hung-Ching, Tolbert, William D., Smith, Amos B., Pazgier, Marzena, Dubé, Mathieu, Clark, Andrew, Mothes, Walther, Kaufmann, Daniel E., Finzi, Andrés
Published in Cell chemical biology (18.05.2023)
Published in Cell chemical biology (18.05.2023)
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Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir
Prévost, Jérémie, Chen, Yaozong, Zhou, Fei, Tolbert, William D., Gasser, Romain, Medjahed, Halima, Nayrac, Manon, Nguyen, Dung N., Gottumukkala, Suneetha, Hessell, Ann J., Rao, Venigalla B., Pozharski, Edwin, Huang, Rick K., Matthies, Doreen, Finzi, Andrés, Pazgier, Marzena
Published in Nature communications (23.10.2023)
Published in Nature communications (23.10.2023)
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Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates
Matsumoto, Kaho, Kuwata, Takeo, Tolbert, William D, Richard, Jonathan, Ding, Shilei, Prévost, Jérémie, Takahama, Shokichi, Judicate, George P, Ueno, Takamasa, Nakata, Hirotomo, Kobayakawa, Takuya, Tsuji, Kohei, Tamamura, Hirokazu, Smith, 3rd, Amos B, Pazgier, Marzena, Finzi, Andrés, Matsushita, Shuzo
Published in Journal of virology (31.01.2023)
Published in Journal of virology (31.01.2023)
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Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics
Tauzin, Alexandra, Marchitto, Lorie, Bélanger, Étienne, Benlarbi, Mehdi, Beaudoin-Bussières, Guillaume, Prévost, Jérémie, Yang, Derek, Chiu, Ta-Jung, Chen, Hung-Ching, Bourassa, Catherine, Medjahed, Halima, Korzeniowski, Marek K, Gottumukkala, Suneetha, Tolbert, William D, Richard, Jonathan, Smith, 3rd, Amos B, Pazgier, Marzena, Finzi, Andrés
Published in Journal of virology (22.10.2024)
Published in Journal of virology (22.10.2024)
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Journal Article
Stabilizing the HIV-1 envelope glycoprotein State 2A conformation
Vézina, Dani, Gong, Shang Yu, Tolbert, William D, Ding, Shilei, Nguyen, Dung, Richard, Jonathan, Gendron-Lepage, Gabrielle, Melillo, 3rd, Bruno, Smith, Amos B, Pazgier, Marzena, Finzi, Andrés
Published in Journal of virology (01.03.2021)
Published in Journal of virology (01.03.2021)
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Systematic mutational analysis of human neutrophil α-defensin HNP4
Hu, Han, Di, Bin, Tolbert, William D., Gohain, Neelakshi, Yuan, Weirong, Gao, Pan, Ma, Bohan, He, Qigai, Pazgier, Marzena, Zhao, Le, Lu, Wuyuan
Published in Biochimica et biophysica acta. Biomembranes (01.04.2019)
Published in Biochimica et biophysica acta. Biomembranes (01.04.2019)
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