Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease
Roberts, Malcolm, Sevastou, Ioanna, Imaizumi, Yoichi, Mistry, Kavita, Talma, Sonia, Dey, Madhurima, Gartlon, Jane, Ochiai, Hiroshi, Zhou, Zhi, Akasofu, Shigeru, Tokuhara, Naoki, Ogo, Makoto, Aoyama, Muneo, Aoyagi, Hirofumi, Strand, Kate, Sajedi, Ezat, Agarwala, Kishan Lal, Spidel, Jared, Albone, Earl, Horie, Kanta, Staddon, James M, de Silva, Rohan
Published in Acta neuropathologica communications (04.02.2020)
Published in Acta neuropathologica communications (04.02.2020)
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Journal Article
N-type Calcium Channel in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
Tokuhara, Naoki, Namiki, Kana, Uesugi, Mai, Miyamoto, Chihiro, Ohgoh, Makoto, Ido, Katsutoshi, Yoshinaga, Takashi, Yamauchi, Toshihiko, Kuromitsu, Junro, Kimura, Sadao, Miyamoto, Norimasa, Kasuya, Yoshitoshi
Published in The Journal of biological chemistry (22.10.2010)
Published in The Journal of biological chemistry (22.10.2010)
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Journal Article
Perampanel: A novel, orally active, noncompetitive AMPA‐receptor antagonist that reduces seizure activity in rodent models of epilepsy
Hanada, Takahisa, Hashizume, Yutaka, Tokuhara, Naoki, Takenaka, Osamu, Kohmura, Naohiro, Ogasawara, Aichi, Hatakeyama, Shinji, Ohgoh, Makoto, Ueno, Masataka, Nishizawa, Yukio
Published in Epilepsia (Copenhagen) (01.07.2011)
Published in Epilepsia (Copenhagen) (01.07.2011)
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Journal Article
Effect of E6060 [4-{5-[7-Fluoro-4-(trifluoromethyl)benzo[b]furan-2-yl]-1H-2-pyrrolyl}benzoic Acid], a Novel Subtype-Selective Retinoid, on Lupus-Like Nephritis in Female (NZBxNZW)F1 Mice
Yamauchi, Toshihiko, Ishibashi, Akira, Shikata, Kohdoh, Tokuhara, Naoki, Seino, Ken-Ichiro, Kobayashi, Seiichi, Nagai, Mitsuo
Published in The Journal of pharmacology and experimental therapeutics (01.03.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2005)
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Journal Article
Mechanism for p38α-mediated Experimental Autoimmune Encephalomyelitis
Namiki, Kana, Matsunaga, Hirofumi, Yoshioka, Kento, Tanaka, Kensuke, Murata, Kazuya, Ishida, Junji, Sakairi, Akira, Kim, Jundal, Tokuhara, Naoki, Shibakawa, Nobuhiko, Shimizu, Motohisa, Wada, Yukinori, Tokunaga, Yasunori, Shigetomi, Manabu, Hagihara, Masahiko, Kimura, Sadao, Sudo, Tatsuhiko, Fukamizu, Akiyoshi, Kasuya, Yoshitoshi
Published in The Journal of biological chemistry (13.07.2012)
Published in The Journal of biological chemistry (13.07.2012)
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Journal Article
E2814: A NOVEL ANTI-TAU THERAPEUTIC ANTIBODY FOR ALZHEIMER’S DISEASE
Roberts, Malcolm, Sevastou, Ioanna, Imaizumi, Yoichi, Mistry, Kavita, Talma, Sonia, Dey, Madhurima, Gartlon, Jane, Ochiai, Hiroshi, Zhou, Zhi, Akasofu, Shigeru, Tokuhara, Naoki, Ogo, Makoto, Strand, Catherine, Agarwala, Kishan, Spidel, Jared, Albone, Earl, Horie, Kanta, Staddon, James, De Silva, Rohan
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Journal Article
P4‐695: E2814: A NOVEL ANTI‐TAU THERAPEUTIC ANTIBODY FOR ALZHEIMER'S DISEASE
Roberts, Malcolm, Sevastou, Ioanna, Imaizumi, Yoichi, Mistry, Kavita, Talma, Sonia, Dey, Madhurima, Gartlon, Jane, Ochiai, Hiroshi, Zhou, Zhi, Akasofu, Shigeru, Tokuhara, Naoki, Ogo, Makoto, Strand, Catherine, Agarwala, Kishan, Spidel, Jared, Albone, Earl, Horie, Kanta, Staddon, James, De Silva, Rohan
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Journal Article
Perampanel: A novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy: Perampanel: A Novel AMPA-R Antagonist
Hanada, Takahisa, Hashizume, Yutaka, Tokuhara, Naoki, Takenaka, Osamu, Kohmura, Naohiro, Ogasawara, Aichi, Hatakeyama, Shinji, Ohgoh, Makoto, Ueno, Masataka, Nishizawa, Yukio
Published in Epilepsia (Copenhagen) (01.07.2011)
Published in Epilepsia (Copenhagen) (01.07.2011)
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Journal Article
Existence of Retinoic Acid-Receptor-Independent Retinoid X-Receptor-Dependent Pathway in Myeloid Cell Function
Hida, Takayuki, Tai, Kenji, Tokuhara, Naoki, Ishibashi, Akira, Kikuchi, Kouichi, Hibi, Shigeki, Yoshimura, Hiroyuki, Nagai, Mitsuo, Yamauchi, Toshihiko, Kobayashi, Seiichi
Published in Japanese Journal of Pharmacology (2001)
Published in Japanese Journal of Pharmacology (2001)
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Journal Article
Effect of E6060 [4-{5-[7-Fluoro-4-(trifluoromethyl)benzo[ b ]furan-2-yl]-1 H -2-pyrrolyl}benzoic Acid], a Novel Subtype-Selective Retinoid, on Lupus-Like Nephritis in Female (NZBxNZW)F1 Mice
Yamauchi, Toshihiko, Ishibashi, Akira, Shikata, Kohdoh, Tokuhara, Naoki, Seino, Ken-ichiro, Kobayashi, Seiichi, Nagai, Mitsuo
Published in The Journal of pharmacology and experimental therapeutics (01.03.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2005)
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Journal Article
Syntheses and Structure−Activity Relationships of 5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-quinoxaline Derivatives with Retinoic Acid Receptor α Agonistic Activity
Kikuchi, Kouichi, Hibi, Shigeki, Yoshimura, Hiroyuki, Tokuhara, Naoki, Tai, Kenji, Hida, Takayuki, Yamauchi, Toshihiko, Nagai, Mitsuo
Published in Journal of medicinal chemistry (10.02.2000)
Published in Journal of medicinal chemistry (10.02.2000)
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Journal Article
Involvement of p38alpha in kainate-induced seizure and neuronal cell damage
Namiki, Kana, Nakamura, Akira, Furuya, Mitsuko, Mizuhashi, Satomi, Matsuo, Yuji, Tokuhara, Naoki, Sudo, Tatsuhiko, Hama, Hiroshi, Kuwaki, Tomoyuki, Yano, Shingo, Kimura, Sadao, Kasuya, Yoshitoshi
Published in Journal of receptors and signal transduction (2007)
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Published in Journal of receptors and signal transduction (2007)
Journal Article
Discovery of Novel and Potent Retinoic Acid Receptor α Agonists: Syntheses and Evaluation of Benzofuranyl-pyrrole and Benzothiophenyl-pyrrole Derivatives
Yoshimura, Hiroyuki, Kikuchi, Kouichi, Hibi, Shigeki, Tagami, Katsuya, Satoh, Takashi, Yamauchi, Toshihiko, Ishibahi, Akira, Tai, Kenji, Hida, Takayuki, Tokuhara, Naoki, Nagai, Mitsuo
Published in Journal of medicinal chemistry (27.07.2000)
Published in Journal of medicinal chemistry (27.07.2000)
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Journal Article
RETINOIC ACID AGONISTS AS PREVENTIVE AND THERAPEUTIC AGENTS FOR NEPHRITIS
ISHIBASHI, AKIRA, NAGAI, MITSUO, YAMAUCHI, TOSHIHIKO, TOKUHARA, NAOKI
Year of Publication 29.04.1999
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Year of Publication 29.04.1999
Patent
Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α antagonists
Kikuchi, Kouichi, Tagami, Katsuya, Hibi, Shigeki, Yoshimura, Hiroyuki, Tokuhara, Naoki, Tai, Kenji, Hida, Takayuki, Yamauchi, Toshihiko, Nagai, Mitsuo
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
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Journal Article
Novel retinoic acid receptor α agonists : Syntheses and evaluation of pyrazole derivatives
KIKUCHI, K, HIBI, S, YOSHIMURA, H, TAI, K, HIDA, T, TOKUHARA, N, YAMAUCHI, T, NAGAI, M
Published in Bioorganic & medicinal chemistry letters (03.04.2000)
Published in Bioorganic & medicinal chemistry letters (03.04.2000)
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Journal Article