Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility
Tanikawa, Chizu, Ueda, Koji, Suzuki, Akari, Iida, Aritoshi, Nakamura, Ryoichi, Atsuta, Naoki, Tohnai, Genki, Sobue, Gen, Saichi, Naomi, Momozawa, Yukihide, Kamatani, Yoichiro, Kubo, Michiaki, Yamamoto, Kazuhiko, Nakamura, Yusuke, Matsuda, Koichi
Published in Cell reports (Cambridge) (06.02.2018)
Published in Cell reports (Cambridge) (06.02.2018)
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Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy
Iida, Madoka, Sahashi, Kentaro, Kondo, Naohide, Nakatsuji, Hideaki, Tohnai, Genki, Tsutsumi, Yutaka, Noda, Seiya, Murakami, Ayuka, Onodera, Kazunari, Okada, Yohei, Nakatochi, Masahiro, Tsukagoshi Okabe, Yuka, Shimizu, Shinobu, Mizuno, Masaaki, Adachi, Hiroaki, Okano, Hideyuki, Sobue, Gen, Katsuno, Masahisa
Published in Nature communications (19.09.2019)
Published in Nature communications (19.09.2019)
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Exercise attenuates polyglutamine‐mediated neuromuscular degeneration in a mouse model of spinal and bulbar muscular atrophy
Hirunagi, Tomoki, Nakatsuji, Hideaki, Sahashi, Kentaro, Yamamoto, Mikiyasu, Iida, Madoka, Tohnai, Genki, Kondo, Naohide, Yamada, Shinichiro, Murakami, Ayuka, Noda, Seiya, Adachi, Hiroaki, Sobue, Gen, Katsuno, Masahisa
Published in Journal of cachexia, sarcopenia and muscle (01.02.2024)
Published in Journal of cachexia, sarcopenia and muscle (01.02.2024)
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SMN2 gene copy number affects the incidence and prognosis of motor neuron diseases in Japan
Ishihara, Tomohiko, Koyama, Akihide, Atsuta, Naoki, Tada, Mari, Toyoda, Saori, Kashiwagi, Kenta, Hirokawa, Sachiko, Hatano, Yuya, Yokoseki, Akio, Nakamura, Ryoichi, Tohnai, Genki, Izumi, Yuishin, Kaji, Ryuji, Morita, Mitsuya, Tamura, Asako, Kano, Osamu, Aoki, Masashi, Kuwabara, Satoshi, Kakita, Akiyoshi, Sobue, Gen, Onodera, Osamu
Published in BMC medical genomics (06.11.2024)
Published in BMC medical genomics (06.11.2024)
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p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model
Doi, Hideki, Adachi, Hiroaki, Katsuno, Masahisa, Minamiyama, Makoto, Matsumoto, Shinjiro, Kondo, Naohide, Miyazaki, Yu, Iida, Madoka, Tohnai, Genki, Qiang, Qiang, Tanaka, Fumiaki, Yanagawa, Toru, Warabi, Eiji, Ishii, Tetsuro, Sobue, Gen
Published in The Journal of neuroscience (01.05.2013)
Published in The Journal of neuroscience (01.05.2013)
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BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1
Ding, Ying, Adachi, Hiroaki, Katsuno, Masahisa, Sahashi, Kentaro, Kondo, Naohide, Iida, Madoka, Tohnai, Genki, Nakatsuji, Hideaki, Sobue, Gen
Published in Neuroscience (07.07.2016)
Published in Neuroscience (07.07.2016)
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Journal Article
DNA methylation inhibitor attenuates polyglutamine‐induced neurodegeneration by regulating Hes5
Kondo, Naohide, Tohnai, Genki, Sahashi, Kentaro, Iida, Madoka, Kataoka, Mayumi, Nakatsuji, Hideaki, Tsutsumi, Yutaka, Hashizume, Atsushi, Adachi, Hiroaki, Koike, Haruki, Shinjo, Keiko, Kondo, Yutaka, Sobue, Gen, Katsuno, Masahisa
Published in EMBO molecular medicine (01.05.2019)
Published in EMBO molecular medicine (01.05.2019)
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Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS
Hirunagi, Tomoki, Sahashi, Kentaro, Tachikawa, Kiyoshi, Leu, Angel I., Nguyen, Michelle, Mukthavaram, Rajesh, Karmali, Priya P., Chivukula, Padmanabh, Tohnai, Genki, Iida, Madoka, Onodera, Kazunari, Ohyama, Manabu, Okada, Yohei, Okano, Hideyuki, Katsuno, Masahisa
Published in Molecular therapy. Nucleic acids (04.06.2021)
Published in Molecular therapy. Nucleic acids (04.06.2021)
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Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration
Kondo, Naohide, Katsuno, Masahisa, Adachi, Hiroaki, Minamiyama, Makoto, Doi, Hideki, Matsumoto, Shinjiro, Miyazaki, Yu, Iida, Madoka, Tohnai, Genki, Nakatsuji, Hideaki, Ishigaki, Shinsuke, Fujioka, Yusuke, Watanabe, Hirohisa, Tanaka, Fumiaki, Nakai, Akira, Sobue, Gen
Published in Nature communications (01.01.2013)
Published in Nature communications (01.01.2013)
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Genistein, a natural product derived from soybeans, ameliorates polyglutamine‐mediated motor neuron disease
Qiang, Qiang, Adachi, Hiroaki, Huang, Zhe, Jiang, Yue‐Mei, Katsuno, Masahisa, Minamiyama, Makoto, Doi, Hideki, Matsumoto, Shinjiro, Kondo, Naohide, Miyazaki, Yu, Iida, Madoka, Tohnai, Genki, Sobue, Gen
Published in Journal of neurochemistry (01.07.2013)
Published in Journal of neurochemistry (01.07.2013)
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Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy
Sahashi, Kentaro, Katsuno, Masahisa, Hung, Gene, Adachi, Hiroaki, Kondo, Naohide, Nakatsuji, Hideaki, Tohnai, Genki, Iida, Madoka, Bennett, C. Frank, Sobue, Gen
Published in Human molecular genetics (01.11.2015)
Published in Human molecular genetics (01.11.2015)
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Journal Article
Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors
Iida, Madoka, Katsuno, Masahisa, Nakatsuji, Hideaki, Adachi, Hiroaki, Kondo, Naohide, Miyazaki, Yu, Tohnai, Genki, Ikenaka, Kensuke, Watanabe, Hirohisa, Yamamoto, Masahiko, Kishida, Ken, Sobue, Gen
Published in Human molecular genetics (15.01.2015)
Published in Human molecular genetics (15.01.2015)
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Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy
Tohnai, Genki, Adachi, Hiroaki, Katsuno, Masahisa, Doi, Hideki, Matsumoto, Shinjiro, Kondo, Naohide, Miyazaki, Yu, Iida, Madoka, Nakatsuji, Hideaki, Qiang, Qiang, Ding, Ying, Watanabe, Hirohisa, Yamamoto, Masahiko, Ohtsuka, Kenzo, Sobue, Gen
Published in Human molecular genetics (2014)
Published in Human molecular genetics (2014)
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Mutation Analysis of the CHCHD2 Gene in Amyotrophic Lateral Sclerosis
Aya Ikeda, Manabu Funayama, Silvio Conedera, Yuanzhe Li, Kenya Nishioka, Naoki Atsuta, Ryoichi Nakamura, Genki Tohnai, Jun Sone, Yuishin Izumi, Ryuji Kaji, Mitsuya Morita, Akira Taniguchi, Gen Sobue, Nobutaka Hattori
Published in Juntendo Medical Journal(2013-) (31.12.2016)
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Published in Juntendo Medical Journal(2013-) (31.12.2016)
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Medical induction of stress response alleviates polyglutamine-mediated motor neuron disease
Adachi, Hiroaki, Tohnai, Genki, Katsuno, Masahisa, Minamiyama, Makoto, Waza, Masahiro, Doi, Hideki, Tanaka, Fumiaki, Ohtsuka, Kenzo, Sobue, Gen
Published in Neuroscience research (2009)
Published in Neuroscience research (2009)
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Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2
Miyazaki, Yu, Adachi, Hiroaki, Katsuno, Masahisa, Minamiyama, Makoto, Jiang, Yue-Mei, Huang, Zhe, Doi, Hideki, Matsumoto, Shinjiro, Kondo, Naohide, Iida, Madoka, Tohnai, Genki, Tanaka, Fumiaki, Muramatsu, Shin-ichi, Sobue, Gen
Published in Nature medicine (01.07.2012)
Published in Nature medicine (01.07.2012)
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The SYNGAP1 3'UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPK
Yokoi, Satoshi, Ito, Takuji, Sahashi, Kentaro, Nakatochi, Masahiro, Nakamura, Ryoichi, Tohnai, Genki, Fujioka, Yusuke, Ishigaki, Shinsuke, Udagawa, Tsuyoshi, Izumi, Yuishin, Morita, Mitsuya, Kano, Osamu, Oda, Masaya, Sone, Takefumi, Okano, Hideyuki, Atsuta, Naoki, Katsuno, Masahisa, Okada, Yohei, Sobue, Gen
Published in The Journal of neuroscience (23.11.2022)
Published in The Journal of neuroscience (23.11.2022)
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Journal Article
Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy
Sahashi, Kentaro, Katsuno, Masahisa, Hung, Gene, Adachi, Hiroaki, Kondo, Naohide, Nakatsuji, Hideaki, Tohnai, Genki, Iida, Madoka, Bennett, C Frank, Sobue, Gen
Published in Human molecular genetics (01.11.2015)
Published in Human molecular genetics (01.11.2015)
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Journal Article
The SYNGAP1 3′UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPK
Yokoi, Satoshi, Ito, Takuji, Sahashi, Kentaro, Nakatochi, Masahiro, Nakamura, Ryoichi, Tohnai, Genki, Fujioka, Yusuke, Ishigaki, Shinsuke, Udagawa, Tsuyoshi, Izumi, Yuishin, Morita, Mitsuya, Kano, Osamu, Oda, Masaya, Sone, Takefumi, Okano, Hideyuki, Atsuta, Naoki, Katsuno, Masahisa, Okada, Yohei, Sobue, Gen
Published in The Journal of neuroscience (23.11.2022)
Published in The Journal of neuroscience (23.11.2022)
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