An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci
Mountjoy, Edward, Schmidt, Ellen M., Carmona, Miguel, Schwartzentruber, Jeremy, Peat, Gareth, Miranda, Alfredo, Fumis, Luca, Hayhurst, James, Buniello, Annalisa, Karim, Mohd Anisul, Wright, Daniel, Hercules, Andrew, Papa, Eliseo, Fauman, Eric B., Barrett, Jeffrey C., Todd, John A., Ochoa, David, Dunham, Ian, Ghoussaini, Maya
Published in Nature genetics (01.11.2021)
Published in Nature genetics (01.11.2021)
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Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics
Ghoussaini, Maya, Mountjoy, Edward, Carmona, Miguel, Peat, Gareth, Schmidt, Ellen M, Hercules, Andrew, Fumis, Luca, Miranda, Alfredo, Carvalho-Silva, Denise, Buniello, Annalisa, Burdett, Tony, Hayhurst, James, Baker, Jarrod, Ferrer, Javier, Gonzalez-Uriarte, Asier, Jupp, Simon, Karim, Mohd Anisul, Koscielny, Gautier, Machlitt-Northen, Sandra, Malangone, Cinzia, Pendlington, Zoe May, Roncaglia, Paola, Suveges, Daniel, Wright, Daniel, Vrousgou, Olga, Papa, Eliseo, Parkinson, Helen, MacArthur, Jacqueline A L, Todd, John A, Barrett, Jeffrey C, Schwartzentruber, Jeremy, Hulcoop, David G, Ochoa, David, McDonagh, Ellen M, Dunham, Ian
Published in Nucleic acids research (08.01.2021)
Published in Nucleic acids research (08.01.2021)
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Preventing type 1 diabetes in childhood
Dayan, Colin M., Besser, Rachel E. J., Oram, Richard A., Hagopian, William, Vatish, Manu, Bendor-Samuel, Owen, Snape, Matthew D., Todd, John A.
Published in Science (American Association for the Advancement of Science) (30.07.2021)
Published in Science (American Association for the Advancement of Science) (30.07.2021)
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Childhood adiposity and risk of type 1 diabetes: A Mendelian randomization study
Censin, J C, Nowak, Christoph, Cooper, Nicholas, Bergsten, Peter, Todd, John A, Fall, Tove
Published in PLoS medicine (01.08.2017)
Published in PLoS medicine (01.08.2017)
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Widespread seasonal gene expression reveals annual differences in human immunity and physiology
Dopico, Xaquin Castro, Evangelou, Marina, Ferreira, Ricardo C., Guo, Hui, Pekalski, Marcin L., Smyth, Deborah J., Cooper, Nicholas, Burren, Oliver S., Fulford, Anthony J., Hennig, Branwen J., Prentice, Andrew M., Ziegler, Anette-G., Bonifacio, Ezio, Wallace, Chris, Todd, John A.
Published in Nature communications (12.05.2015)
Published in Nature communications (12.05.2015)
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Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus
Downes, Damien J., Cross, Amy R., Hua, Peng, Roberts, Nigel, Schwessinger, Ron, Cutler, Antony J., Munis, Altar M., Brown, Jill, Mielczarek, Olga, de Andrea, Carlos E., Melero, Ignacio, Gill, Deborah R., Hyde, Stephen C., Knight, Julian C., Todd, John A., Sansom, Stephen N., Issa, Fadi, Davies, James O. J., Hughes, Jim R.
Published in Nature genetics (01.11.2021)
Published in Nature genetics (01.11.2021)
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Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk
Hu, Xinli, Deutsch, Aaron J, Lenz, Tobias L, Onengut-Gumuscu, Suna, Han, Buhm, Chen, Wei-Min, Howson, Joanna M M, Todd, John A, de Bakker, Paul I W, Rich, Stephen S, Raychaudhuri, Soumya
Published in Nature genetics (01.08.2015)
Published in Nature genetics (01.08.2015)
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Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells
Inaba, Akimichi, Tuong, Zewen Kelvin, Zhao, Tian X., Stewart, Andrew P., Mathews, Rebeccah, Truman, Lucy, Sriranjan, Rouchelle, Kennet, Jane, Saeb-Parsy, Kourosh, Wicker, Linda, Waldron-Lynch, Frank, Cheriyan, Joseph, Todd, John A., Mallat, Ziad, Clatworthy, Menna R.
Published in Nature communications (12.04.2023)
Published in Nature communications (12.04.2023)
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Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes
Westra, Harm-Jan, Martínez-Bonet, Marta, Onengut-Gumuscu, Suna, Lee, Annette, Luo, Yang, Teslovich, Nikola, Worthington, Jane, Martin, Javier, Huizinga, Tom, Klareskog, Lars, Rantapaa-Dahlqvist, Solbritt, Chen, Wei-Min, Quinlan, Aaron, Todd, John A., Eyre, Steve, Nigrovic, Peter A., Gregersen, Peter K., Rich, Stephen S., Raychaudhuri, Soumya
Published in Nature genetics (01.10.2018)
Published in Nature genetics (01.10.2018)
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Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases
Plagnol, Vincent, Howson, Joanna M M, Smyth, Deborah J, Walker, Neil, Hafler, Jason P, Wallace, Chris, Stevens, Helen, Jackson, Laura, Simmonds, Matthew J, Bingley, Polly J, Gough, Stephen C, Todd, John A
Published in PLoS genetics (01.08.2011)
Published in PLoS genetics (01.08.2011)
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Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls
Fortune, Mary D, Guo, Hui, Burren, Oliver, Schofield, Ellen, Walker, Neil M, Ban, Maria, Sawcer, Stephen J, Bowes, John, Worthington, Jane, Barton, Anne, Eyre, Steve, Todd, John A, Wallace, Chris
Published in Nature genetics (01.07.2015)
Published in Nature genetics (01.07.2015)
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A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes
FERREIRA, Ricardo C, HUI GUO, LYONS, Paul A, SMITH, Kenneth G. C, ACHENBACH, Peter, BEYERLEIN, Andreas, DUNGER, David B, CLAYTON, David G, WICKER, Linda S, TODD, John A, BONIFACIO, Ezio, WALLACE, Chris, COULSON, Richard M. R, ZIEGLER, Anette-G, SMYTH, Deborah J, PEKALSKI, Marcin L, BURREN, Oliver S, CUTLER, Antony J, DOECKE, James D, FLINT, Shaun, MCKINNEY, Eoin F
Published in Diabetes (New York, N.Y.) (01.07.2014)
Published in Diabetes (New York, N.Y.) (01.07.2014)
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Elevations in blood glucose before and after the appearance of islet autoantibodies in children
Warncke, Katharina, Weiss, Andreas, Achenbach, Peter, von dem Berge, Thekla, Berner, Reinhard, Casteels, Kristina, Groele, Lidia, Hatzikotoulas, Konstantinos, Hommel, Angela, Kordonouri, Olga, Elding Larsson, Helena, Lundgren, Markus, Marcus, Benjamin A, Snape, Matthew D, Szypowska, Agnieszka, Todd, John A, Bonifacio, Ezio, Ziegler, Anette-G
Published in The Journal of clinical investigation (17.10.2022)
Published in The Journal of clinical investigation (17.10.2022)
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Pooled RNA-extraction-free testing of saliva for the detection of SARS-CoV-2
Allicock, Orchid M., Yolda-Carr, Devyn, Todd, John A., Wyllie, Anne L.
Published in Scientific reports (08.05.2023)
Published in Scientific reports (08.05.2023)
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Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach
Richardson, Tom G., Crouch, Daniel J. M., Power, Grace M., Morales-Berstein, Fernanda, Hazelwood, Emma, Fang, Si, Cho, Yoonsu, Inshaw, Jamie R. J., Robertson, Catherine C., Sidore, Carlo, Cucca, Francesco, Rich, Steven S., Todd, John A., Davey Smith, George
Published in Nature communications (28.04.2022)
Published in Nature communications (28.04.2022)
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Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases
Ferreira, Ricardo C, Freitag, Daniel F, Cutler, Antony J, Howson, Joanna M M, Rainbow, Daniel B, Smyth, Deborah J, Kaptoge, Stephen, Clarke, Pamela, Boreham, Charlotte, Coulson, Richard M, Pekalski, Marcin L, Chen, Wei-Min, Onengut-Gumuscu, Suna, Rich, Stephen S, Butterworth, Adam S, Malarstig, Anders, Danesh, John, Todd, John A
Published in PLoS genetics (01.04.2013)
Published in PLoS genetics (01.04.2013)
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Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease
Smyth, Deborah J, Plagnol, Vincent, Walker, Neil M, Cooper, Jason D, Downes, Kate, Yang, Jennie H.M, Howson, Joanna M.M, Stevens, Helen, McManus, Ross, Wijmenga, Cisca, Heap, Graham A, Dubois, Patrick C, Clayton, David G, Hunt, Karen A, van Heel, David A, Todd, John A
Published in The New England journal of medicine (25.12.2008)
Published in The New England journal of medicine (25.12.2008)
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Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
Cooper, Jason D, Smyth, Deborah J, Smiles, Adam M, Plagnol, Vincent, Walker, Neil M, Allen, James E, Downes, Kate, Barrett, Jeffrey C, Healy, Barry C, Mychaleckyj, Josyf C, Warram, James H, Todd, John A
Published in Nature genetics (01.12.2008)
Published in Nature genetics (01.12.2008)
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