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A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy
Li, John Y., Perry, Samuel R., Muniz-Medina, Vanessa, Wang, Xinzhong, Wetzel, Leslie K., Rebelatto, Marlon C., Hinrichs, Mary Jane Masson, Bezabeh, Binyam Z., Fleming, Ryan L., Dimasi, Nazzareno, Feng, Hui, Toader, Dorin, Yuan, Andy Q., Xu, Lan, Lin, Jia, Gao, Changshou, Wu, Herren, Dixit, Rakesh, Osbourn, Jane K., Coats, Steven R.
Published in Cancer cell (11.01.2016)
Published in Cancer cell (11.01.2016)
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Tumor cell-directed STING agonist antibody-drug conjugates induce type III interferons and anti-tumor innate immune responses
Malli Cetinbas, Naniye, Monnell, Travis, Soomer-James, Jahna, Shaw, Pamela, Lancaster, Kelly, Catcott, Kalli C., Dolan, Melissa, Mosher, Rebecca, Routhier, Caitlin, Chin, Chen-Ni, Toader, Dorin, Duvall, Jeremy, Bukhalid, Raghida, Lowinger, Timothy B., Damelin, Marc
Published in Nature communications (11.07.2024)
Published in Nature communications (11.07.2024)
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Mechanism and In Vitro Pharmacology of TAK1 Inhibition by (5Z)‑7-Oxozeaenol
Wu, Jiaquan, Powell, Francoise, Larsen, Nicholas A, Lai, Zhongwu, Byth, Kate F, Read, Jon, Gu, Rong-Fang, Roth, Mark, Toader, Dorin, Saeh, Jamal Carlos, Chen, Huawei
Published in ACS chemical biology (15.03.2013)
Published in ACS chemical biology (15.03.2013)
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Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4
Harper, Jay, Lloyd, Christopher, Dimasi, Nazzareno, Toader, Dorin, Marwood, Rose, Lewis, Leeanne, Bannister, David, Jovanovic, Jelena, Fleming, Ryan, D'Hooge, Francois, Mao, Shenlan, Marrero, Allison M., Korade, Martin, Strout, Patrick, Xu, Linda, Chen, Cui, Wetzel, Leslie, Breen, Shannon, van Vlerken-Ysla, Lilian, Jalla, Sanjoo, Rebelatto, Marlon, Zhong, Haihong, Hurt, Elaine M., Hinrichs, Mary Jane, Huang, Keven, Howard, Philip W., Tice, David A., Hollingsworth, Robert E., Herbst, Ronald, Kamal, Adeela
Published in Molecular cancer therapeutics (01.08.2017)
Published in Molecular cancer therapeutics (01.08.2017)
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Essential role of TAK1 in regulating mantle cell lymphoma survival
Buglio, Daniela, Palakurthi, Sangeetha, Byth, Kate, Vega, Francisco, Toader, Dorin, Saeh, Jamal, Neelapu, Sattva S., Younes, Anas
Published in Blood (12.07.2012)
Published in Blood (12.07.2012)
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A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy
Li, John Y., Perry, Samuel R., Muniz-Medina, Vanessa, Wang, Xinzhong, Wetzel, Leslie K., Rebelatto, Marlon C., Masson Hinrichs, Mary Jane, Bezabeh, Binyam Z., Fleming, Ryan L., Dimasi, Nazzareno, Feng, Hui, Toader, Dorin, Yuan, Andy Q., Xu, Lan, Lin, Jia, Gao, Changshou, Wu, Herren, Dixit, Rakesh, Osbourn, Jane K., Coats, Steven R.
Published in Cancer cell (10.06.2019)
Published in Cancer cell (10.06.2019)
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Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas
Oza, Vibha, Ashwell, Susan, Almeida, Lynsie, Brassil, Patrick, Breed, Jason, Deng, Chun, Gero, Thomas, Grondine, Michael, Horn, Candice, Ioannidis, Stephanos, Liu, Dongfang, Lyne, Paul, Newcombe, Nicholas, Pass, Martin, Read, Jon, Ready, Shannon, Rowsell, Siân, Su, Mei, Toader, Dorin, Vasbinder, Melissa, Yu, Dingwei, Yu, Yan, Xue, Yafeng, Zabludoff, Sonya, Janetka, James
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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Straightforward Glycoengineering Approach to Site-Specific Antibody–Pyrrolobenzodiazepine Conjugates
Thompson, Pamela, Ezeadi, Ebele, Hutchinson, Ian, Fleming, Ryan, Bezabeh, Binyam, Lin, Jia, Mao, Shenlan, Chen, Cui, Masterson, Luke, Zhong, Haihong, Toader, Dorin, Howard, Philip, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno
Published in ACS medicinal chemistry letters (10.11.2016)
Published in ACS medicinal chemistry letters (10.11.2016)
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785 STING-agonist ADCs targeting tumor-associated antigens coordinate immune-mediated killing of antigen-negative cancer cells
Wongthida, Phonphimon, Catcott, Kalli, Lancaster, Kelly, Bentley, Keith, Dirksen, Anouk, Du, Bingfan, Eitas, Timothy, Kelleher, Eugene, Malli, Naniye, Mosher, Rebecca, Protopopova, Marina, Shaw, Pamela, Stevenson, Cheri, Thomas, Joshua, Uttard, Alex, Duvall, Jeremy, Toader, Dorin, Damelin, Marc, Bukhalid, Raghida, Lowinger, Timothy
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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620 Tumor cell-intrinsic STING pathway is activated in the presence of cues from immune cells and contributes to the anti-tumor activity of tumor cell-targeted STING agonist antibody-drug conjugates
Cetinbas, Naniye Malli, Monnell, Travis, Lee, Winnie, Catcott, Kalli, Chin, Chen-Ni, Shaw, Pamela, Slocum, Kelly, Qin, LiuLiang, Avocetien, Kenneth, Bentley, Keith, Clardy, Susan, Jones, Brian, Kelleher, Eugene, Thomas, Joshua, Mosher, Rebecca, Toader, Dorin, Duvall, Jeremy, Bukhalid, Raghida, Damelin, Marc, Lowinger, Timothy
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors—Hit to lead exploration
Oza, Vibha, Ashwell, Susan, Brassil, Patrick, Breed, Jason, Deng, Chun, Ezhuthachan, Jay, Haye, Heather, Horn, Candice, Janetka, James, Lyne, Paul, Newcombe, Nicholas, Otterbien, Ludo, Pass, Martin, Read, Jon, Roswell, Sian, Su, Mei, Toader, Dorin, Yu, Dingwei, Yu, Yan, Valentine, Anna, Webborn, Peter, White, Ann, Zabludoff, Sonya, Zheng, Xiaolan
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors
Janetka, James W., Almeida, Lynsie, Ashwell, Susan, Brassil, Patrick J., Daly, Kevin, Deng, Chun, Gero, Thomas, Glynn, Roberta E., Horn, Candice L., Ioannidis, Stephanos, Lyne, Paul, Newcombe, Nicholas J., Oza, Vibha B., Pass, Martin, Springer, Stephanie K., Su, Mei, Toader, Dorin, Vasbinder, Melissa M., Yu, Dingwei, Yu, Yan, Zabludoff, Sonya D.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates
Duvall, Jeremy R., Thomas, Joshua D., Bukhalid, Raghida A., Catcott, Kalli C., Bentley, Keith W., Collins, Scott D., Eitas, Timothy, Jones, Brian D., Kelleher, Eugene W., Lancaster, Kelly, Protopopova, Marina, Ray, Soumya S., Ter-Ovanesyan, Elena, Xu, Ling, Yang, Liping, Zurita, Jeffrey, Damelin, Marc, Toader, Dorin, Lowinger, Timothy B.
Published in Journal of medicinal chemistry (10.08.2023)
Published in Journal of medicinal chemistry (10.08.2023)
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Structural approaches to obtain kinase selectivity
Norman, Richard A., Toader, Dorin, Ferguson, Andrew D.
Published in Trends in pharmacological sciences (Regular ed.) (01.05.2012)
Published in Trends in pharmacological sciences (Regular ed.) (01.05.2012)
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XMT-2056, a HER2-Directed STING Agonist Antibody–Drug Conjugate, Induces Innate Antitumor Immune Responses by Acting on Cancer Cells and Tumor-Resident Immune Cells
Bukhalid, Raghida A., Duvall, Jeremy R., Lancaster, Kelly, Catcott, Kalli C., Malli Cetinbas, Naniye, Monnell, Travis, Routhier, Caitlin, Thomas, Joshua D., Bentley, Keith W., Collins, Scott D., Ditty, Elizabeth, Eitas, Timothy K., Kelleher, Eugene W., Shaw, Pamela, Soomer-James, Jahna, Ter-Ovanesyan, Elena, Xu, Ling, Zurita, Jeffrey, Toader, Dorin, Damelin, Marc, Lowinger, Timothy B.
Published in Clinical cancer research (01.05.2025)
Published in Clinical cancer research (01.05.2025)
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Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody–Drug Conjugate for the Treatment of Cancer
Toader, Dorin, Fessler, Shawn P., Collins, Scott D., Conlon, Patrick R., Bollu, Reddy, Catcott, Kalli C., Chin, Chen-Ni, Dirksen, Anouk, Du, Bingfan, Duvall, Jeremy R., Higgins, Stacy, Kozytska, Mariya V., Bellovoda, Kamela, Faircloth, Chelsey, Lee, David, Li, Fu, Qin, Liuliang, Routhier, Caitlin, Shaw, Pamela, Stevenson, Cheri A., Wang, Jason, Wongthida, Phonphimon, Ter-Ovanesyan, Elena, Ditty, Elizabeth, Bradley, Stephen P., Xu, Ling, Yin, Mao, Yurkovetskiy, Alexandr V., Mosher, Rebecca, Damelin, Marc, Lowinger, Timothy B.
Published in Molecular cancer therapeutics (09.06.2023)
Published in Molecular cancer therapeutics (09.06.2023)
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Development of a Novel DNA Mono-alkylator Platform for Antibody–Drug Conjugates
Thomas, Joshua D., Yurkovetskiy, Aleksandr V., Yin, Mao, Bodyak, Natalya D., Tang, Shuyi, Protopopova, Marina, Kelleher, Eugene, Jones, Brian, Yang, Liping, Custar, Daniel, Catcott, Kalli C., Demady, Damon R., Collins, Scott D., Xu, Ling, Bu, Charlie, Qin, LiuLiang, Ter-Ovanesyan, Elena, Damelin, Marc, Toader, Dorin, Lowinger, Timothy B.
Published in Molecular cancer therapeutics (02.04.2024)
Published in Molecular cancer therapeutics (02.04.2024)
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STING 효능제를 포함하는 항체 약물 접합체, 조합 및 사용 방법
TOADER DORIN, BUKHALID RAGHIDA A, LOWINGER TIMOTHY B, CETINBAS NANIYE, DAMELIN MARC I
Year of Publication 16.10.2024
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Year of Publication 16.10.2024
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