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Published in Clinical cancer research (15.06.2017)
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Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
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An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia
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Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function
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Published in Proceedings of the National Academy of Sciences - PNAS (18.06.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (18.06.2013)
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Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition
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Published in Blood (22.05.2014)
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Validation and refinement of a RUNX1 mutation-associated gene expression signature in blast crisis chronic myeloid leukemia
Lee, Kian Leong, Ko, Tun Kiat, Saw, Nicole Y L, Javed, Asif, Hillmer, Axel M, Chuah, Charles, Krishnan, Vaidehi, Ong, S Tiong
Published in Leukemia (01.03.2022)
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Phase I study of vorinostat with gefitinib in BIM deletion polymorphism/epidermal growth factor receptor mutation double‐positive lung cancer
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Published in Cancer science (01.02.2020)
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THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors
Shyamsunder, Pavithra, Sridharan, Shree Pooja, Madan, Vikas, Dakle, Pushkar, Zeya, Cao, Kanojia, Deepika, Chng, Wee-Joo, Ong, S Tiong, Koeffler, H Phillip
Published in International journal of molecular sciences (21.01.2022)
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The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target
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Published in PloS one (11.10.2018)
Published in PloS one (11.10.2018)
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Resminostat, a histone deacetylase inhibitor, circumvents tolerance to EGFR inhibitors in EGFR-mutated lung cancer cells with BIM deletion polymorphism
Arai, Sachiko, Takeuchi, Shinji, Fukuda, Koji, Tanimoto, Azusa, Nishiyama, Akihiro, Konishi, Hiroaki, Takagi, Akimitsu, Takahashi, Hiroyuki, Ong, S. Tiong, Yano, Seiji
Published in The Journal of Medical Investigation (2020)
Published in The Journal of Medical Investigation (2020)
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Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a BIM deletion polymorphism in pediatric acute lymphoblastic leukemia
Soh, Sheila Xinxuan, Lim, Joshua Yew Suang, Huang, John W J, Jiang, Nan, Yeoh, Allen Eng Juh, Ong, S Tiong
Published in PloS one (04.08.2014)
Published in PloS one (04.08.2014)
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Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin
LY, Chi, ARECHIGA, Adrian F, MELO, Junia V, WALSH, Craig M, TIONG ONG, S
Published in Cancer research (Chicago, Ill.) (15.09.2003)
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Published in Cancer research (Chicago, Ill.) (15.09.2003)
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The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia
Ko, Tun Kiat, Chin, Hui San, Chuah, Charles T H, Huang, John W J, Ng, King-Pan, Khaw, Seong Lin, Huang, David C S, Ong, S Tiong
Published in Oncotarget (19.01.2016)
Published in Oncotarget (19.01.2016)
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Inhibition of Polysome Assembly Enhances Imatinib Activity against Chronic Myelogenous Leukemia and Overcomes Imatinib Resistance
Zhang, Min, Fu, Wuxia, Prabhu, Sharmila, Moore, James C., Ko, Je, Kim, Jung Woo, Druker, Brian J., Trapp, Valerie, Fruehauf, John, Gram, Hermann, Fan, Hung Y., Ong, S. Tiong
Published in Molecular and Cellular Biology (01.10.2008)
Published in Molecular and Cellular Biology (01.10.2008)
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A systematic review and meta-analysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer
Soh, Sheila X, Siddiqui, Fahad J, Allen, John C, Kim, Go Woon, Lee, Jae Cheol, Yatabe, Yasushi, Soda, Manabu, Mano, Hiroyuki, Soo, Ross A, Chin, Tan-Min, Ebi, Hiromichi, Yano, Seiji, Matsuo, Keitaro, Niu, Xiaomin, Lu, Shun, Isobe, Kazutoshi, Lee, Jih-Hsiang, Yang, James C, Zhao, Mingchuan, Zhou, Caicun, Lee, June-Koo, Lee, Se-Hoon, Lee, Ji Yun, Ahn, Myung-Ju, Tan, Tira J, Tan, Daniel S, Tan, Eng-Huat, Ong, S Tiong, Lim, Wan-Teck
Published in Oncotarget (20.06.2017)
Published in Oncotarget (20.06.2017)
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