1,2-Dihydro-4-quinazolinamines: Potent, Highly Selective Inhibitors of Inducible Nitric Oxide Synthase Which Show Antiinflammatory Activity in Vivo
Tinker, Alan C, Beaton, Haydn G, Boughton-Smith, Nigel, Cooper, Sally L, Fraser-Rae, Lynne, Hallam, Kay, Hamley, Peter, McInally, Tom, Nicholls, David J, Pimm, Austen D, Wallace, Alan V
Published in Journal of medicinal chemistry (13.03.2003)
Published in Journal of medicinal chemistry (13.03.2003)
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Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase
Garcin, Elsa D, Getzoff, Elizabeth D, Arvai, Andrew S, Rosenfeld, Robin J, Kroeger, Matt D, Crane, Brian R, Andersson, Gunilla, Andrews, Glen, Hamley, Peter J, Mallinder, Philip R, Nicholls, David J, St-Gallay, Stephen A, Tinker, Alan C, Gensmantel, Nigel P, Mete, Antonio, Cheshire, David R, Connolly, Stephen, Stuehr, Dennis J, Åberg, Anders, Wallace, Alan V, Tainer, John A
Published in Nature chemical biology (01.11.2008)
Published in Nature chemical biology (01.11.2008)
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Components of successful lead generation
Davis, Andrew M, Keeling, David J, Steele, John, Tomkinson, Nicholas P, Tinker, Alan C
Published in Current topics in medicinal chemistry (01.01.2005)
Published in Current topics in medicinal chemistry (01.01.2005)
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2-Aminopyridines as Highly Selective Inducible Nitric Oxide Synthase Inhibitors. Differential Binding Modes Dependent on Nitrogen Substitution
Connolly, Stephen, Aberg, Anders, Arvai, Andrew, Beaton, Haydn G, Cheshire, David R, Cook, Anthony R, Cooper, Sally, Cox, David, Hamley, Peter, Mallinder, Phil, Millichip, Ian, Nicholls, David J, Rosenfeld, Robin J, St-Gallay, Stephen A, Tainer, John, Tinker, Alan C, Wallace, Alan V
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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3,4-Dihydro-1-isoquinolinamines: A novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency
Beaton, Haydn, Hamley, Peter, Nicholls, David J, Tinker, Alan C, Wallace, Alan V
Published in Bioorganic & medicinal chemistry letters (23.04.2001)
Published in Bioorganic & medicinal chemistry letters (23.04.2001)
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Electrophilic substitution in indoles. Part 15. The reaction between methylenedi-indoles and p-nitrobenzenediazonium fluoroborate
Jackson, Anthony H., Prasitpan, Noojaree, Shannon, Patrick V. R., Tinker, Alan C.
Published in Journal of the Chemical Society, Perkin Transactions 1 (1987)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1987)
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Inhibitors of nitric oxide synthase in inflammatory arthritis
Boughton-Smith, N K, Tinker, A C
Published in IDrugs : the investigational drugs journal (01.07.1998)
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Published in IDrugs : the investigational drugs journal (01.07.1998)
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New non-peptide angiotensin II receptor antagonists. 1: structure - activity relationships of a series of a series of 2(1H)-pyridinones
Bantick, John R., Beaton, Haydn G., Cooper, Sally L., Hill, Stephen, Hirst, Simon C., McInally, Thomas, Spencer, Jane, Tinker, Alan C., Willis, Paul A.
Published in Bioorganic & medicinal chemistry letters (1994)
Published in Bioorganic & medicinal chemistry letters (1994)
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New non-peptide angiotensin II receptor antagonists. 2: structure - activity relationship of a series of annelated 2(1H)-pyridinones
Bantick, John R., Beaton, Haydn G., Cooper, Sally L., Hill, Stephen, Hirst, Simon C., McInally, Tom, Spencer, Jane, Tinker, Alan C., Willis, Paul A.
Published in Bioorganic & medicinal chemistry letters (1994)
Published in Bioorganic & medicinal chemistry letters (1994)
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