The physiological interactome of TCR-like antibody therapeutics in human tissues
Marrer-Berger, Estelle, Nicastri, Annalisa, Augustin, Angelique, Kramar, Vesna, Liao, Hanqing, Hanisch, Lydia Jasmin, Carpy, Alejandro, Weinzierl, Tina, Durr, Evelyne, Schaub, Nathalie, Nudischer, Ramona, Ortiz-Franyuti, Daniela, Breous-Nystrom, Ekaterina, Stucki, Janick, Hobi, Nina, Raggi, Giulia, Cabon, Lauriane, Lezan, Emmanuelle, Umaña, Pablo, Woodhouse, Isaac, Bujotzek, Alexander, Klein, Christian, Ternette, Nicola
Published in Nature communications (16.04.2024)
Published in Nature communications (16.04.2024)
Get full text
Journal Article
Pharmacokinetics and Pharmacodynamics of T-Cell Bispecifics in the Tumour Interstitial Fluid
Eigenmann, Miro Julian, Karlsen, Tine Veronica, Wagner, Marek, Tenstad, Olav, Weinzierl, Tina, Fauti, Tanja, Grimm, Hans Peter, Skogstrand, Trude, Klein, Christian, Sam, Johannes, Umana, Pablo, Bacac, Marina, Wiig, Helge, Walz, Antje-Christine
Published in Pharmaceutics (07.12.2021)
Published in Pharmaceutics (07.12.2021)
Get full text
Journal Article
A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
Bacac, Marina, Fauti, Tanja, Sam, Johannes, Colombetti, Sara, Weinzierl, Tina, Ouaret, Djamila, Bodmer, Walter, Lehmann, Steffi, Hofer, Thomas, Hosse, Ralf J, Moessner, Ekkehard, Ast, Oliver, Bruenker, Peter, Grau-Richards, Sandra, Schaller, Teilo, Seidl, Annette, Gerdes, Christian, Perro, Mario, Nicolini, Valeria, Steinhoff, Nathalie, Dudal, Sherri, Neumann, Sebastian, von Hirschheydt, Thomas, Jaeger, Christiane, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umaña, Pablo
Published in Clinical cancer research (01.07.2016)
Published in Clinical cancer research (01.07.2016)
Get full text
Journal Article
Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models
Herter, Sylvia, Herting, Frank, Mundigl, Olaf, Waldhauer, Inja, Weinzierl, Tina, Fauti, Tanja, Muth, Gunter, Ziegler-Landesberger, Doris, Van Puijenbroek, Erwin, Lang, Sabine, Duong, Minh Ngoc, Reslan, Lina, Gerdes, Christian A, Friess, Thomas, Baer, Ute, Burtscher, Helmut, Weidner, Michael, Dumontet, Charles, Umana, Pablo, Niederfellner, Gerhard, Bacac, Marina, Klein, Christian
Published in Molecular cancer therapeutics (01.10.2013)
Published in Molecular cancer therapeutics (01.10.2013)
Get full text
Journal Article
A Novel Approach for Quantifying the Pharmacological Activity of T-Cell Engagers Utilizing In Vitro Time Course Experiments and Streamlined Data Analysis
Van De Vyver, Arthur, Eigenmann, Miro, Ovacik, Meric, Pohl, Christian, Herter, Sylvia, Weinzierl, Tina, Fauti, Tanja, Klein, Christian, Lehr, Thorsten, Bacac, Marina, Walz, Antje-Christine
Published in The AAPS journal (03.12.2021)
Published in The AAPS journal (03.12.2021)
Get full text
Journal Article
Predicting Tumor Killing and T-Cell Activation by T-Cell Bispecific Antibodies as a Function of Target Expression: Combining In Vitro Experiments with Systems Modeling
Van De Vyver, Arthur J, Weinzierl, Tina, Eigenmann, Miro J, Frances, Nicolas, Herter, Sylvia, Buser, Regula B, Somandin, Jitka, Diggelmann, Sarah, Limani, Florian, Lehr, Thorsten, Bacac, Marina, Walz, Antje-Christine
Published in Molecular cancer therapeutics (01.02.2021)
Published in Molecular cancer therapeutics (01.02.2021)
Get full text
Journal Article
Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies
Kerns, S Jordan, Belgur, Chaitra, Petropolis, Debora, Kanellias, Marianne, Barrile, Riccardo, Sam, Johannes, Weinzierl, Tina, Fauti, Tanja, Freimoser-Grundschober, Anne, Eckmann, Jan, Hage, Carina, Geiger, Martina, Ng, Patrick Ray, Tien-Street, William, Manatakis, Dimitris V, Micallef, Virginie, Gerard, Regine, Bscheider, Michael, Breous-Nystrom, Ekaterina, Schneider, Anneliese, Giusti, Anna Maria, Bertinetti-Lapatki, Cristina, Grant, Heather Shannon, Roth, Adrian B, Hamilton, Geraldine A, Singer, Thomas, Karalis, Katia, Moisan, Annie, Bruenker, Peter, Klein, Christian, Bacac, Marina, Gjorevski, Nikolce, Cabon, Lauriane
Published in eLife (11.08.2021)
Published in eLife (11.08.2021)
Get full text
Journal Article
BISPECIFIC T CELL-ACTIVATING ANTIGEN-BINDING MOLECULES
CHRISTIAN KLEIN, MARINA BACAC, RALF HOSSE, CHRISTIANE JAEGER, MOESSNER EKKEHARD, PABLO UMANA, TINA WEINZIERL, THOMAS HOFER
Year of Publication 09.09.2021
Get full text
Year of Publication 09.09.2021
Patent
XGFR, a novel affinity-matured bispecific antibody targeting IGF-1R and EGFR with combined signaling inhibition and enhanced immune activation for the treatment of pancreatic cancer
Schanzer, Juergen M, Wartha, Katharina, Moessner, Ekkehard, Hosse, Ralf J, Moser, Samuel, Croasdale, Rebecca, Trochanowska, Halina, Shao, Cuiying, Wang, Peng, Shi, Lei, Weinzierl, Tina, Rieder, Natascha, Bacac, Marina, Ries, Carola H, Kettenberger, Hubert, Schlothauer, Tilman, Friess, Thomas, Umana, Pablo, Klein, Christian
Published in mAbs (18.05.2016)
Published in mAbs (18.05.2016)
Get full text
Journal Article
Abstract 2955: Herceptarg, a novel heterodimeric biparatopic common light chain IgG1 antibody based on trastuzumab and pertuzumab, exerts potent anti-tumoral activity
Moessner, Ekkehard, Hofer, Thomas, Waldhauer, Inja, Scheuer, Werner, Hosse, Ralf, Duerner, Lydia, He, Mi, Zick, Karlheinz, Fischer, Jens, Sustmann, Claudio, Weinzierl, Tina, Bacac, Marina, Gerdes, Christian, Umana, Pablo, Klein, Christian
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Get full text
Journal Article
Abstract 3629: Engineering a novel asymmetric head-to-tail 2+1 T-cell bispecific (2+1 TCB) IgG antibody platform with superior T-cell killing compared to 1+1 asymmetric TCBs
Klein, Christian, Neumann, Christiane, Fauti, Tanja, Weinzierl, Tina, Freimoser-Grundschober, Anne, Waldhauer, Inja, Fahrni, Linda, Herter, Sylvia, Puijenbroek, Erwin van, Colombetti, Sara, Sam, Johannes, Lang, Sabine, Dudal, Sherri, Schäfer, Wolfgang, Regula, Jörg T., Moser, Samuel, Ast, Oliver, Hosse, Ralf, Mössner, Ekkehard, Brünker, Peter, Bacac, Marina, Umana, Pablo
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
BISPECIFIC ANTIBODIES TARGETING CD3 AND FolR1
CHRISTIAN KLEIN, PETER BRUENKER, ANNE FREIMOSER-GRUNDSCHOBER, MARINA BACAC, RALF HOSSE, MOESSNER EKKEHARD, PABLO UMANA, TINA WEINZIERL
Year of Publication 15.04.2021
Get full text
Year of Publication 15.04.2021
Patent
BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
CHRISTIAN KLEIN, MARINA BACAC, RALF HOSSE, CHRISTIANE JAEGER, MOESSNER EKKEHARD, PABLO UMANA, TINA WEINZIERL, THOMAS HOFER
Year of Publication 05.03.2020
Get full text
Year of Publication 05.03.2020
Patent
A New Class of T-Cell Bispecific Antibodies for the Treatment of Multiple Myeloma, Binding to B Cell Maturation Antigen and CD3 and Showing Potent, Specific Antitumor Activity in Myeloma Cells and Long Duration of Action in Cynomolgus Monkeys
Vu, Minh Diem, Moser, Samuel, Delon, Camille, Latzko, Melanie, Gianotti, Reto, Lüoend, Remo, Friang, Chloé, Murr, Ramona, Duerner, Lydia Jasmin, Weinzierl, Tina, Fauti, Tanja, Bacac, Marina, Ast, Oliver, Freimoser-Grundschober, Anne, Rodriguez Diaz, Tea, Zielonka, Jörg, van Puijenbroek, Erwin, Hosse, Ralf, Bruenker, Peter, Mössner, Ekkehard, Klein, Christian, Umaña, Pablo, Strein, Klaus
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
Get full text
Journal Article
BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
CHRISTIAN KLEIN, MARINA BACAC, RALF HOSSE, CHRISTIANE JAEGER, MOESSNER EKKEHARD, PABLO UMANA, TINA WEINZIERL, THOMAS HOFER
Year of Publication 14.09.2017
Get full text
Year of Publication 14.09.2017
Patent
MONOCLONAL ANTIBODIES AGAINST BCMA
AST OLIVER, MESSNER EKKEHARD, KLEIN CHRISTIAN, ANNE FREIMOSER-GRUNDSCHOBER, SAMUEL MOSER, MARINA BACAC, MINH DIEM VU, PABLO UMANA, TINA WEINZIERL, KLAUS STREIN, CAMILLE DELON, JASMIN DUERNER LYDIA
Year of Publication 16.07.2020
Get full text
Year of Publication 16.07.2020
Patent
ANTIBODIES BINDING TO STEAP-1
WEINZIERL, Tina, KOENIG, Maximiliane, LARIVIERE, Laurent, HOFER, Thomas, NIEWOEHNER, Jens, MOESSNER, Ekkehard
Year of Publication 22.08.2024
Get full text
Year of Publication 22.08.2024
Patent
Bispecific T cell activating antigen binding molecules
WEINZIERL, Tina, BACAC, Marina, JAEGER, Christiane, HOSSE, Ralf, HOFER, Thomas, UMANA, Pablo, KLEIN, Christian, MOESSNER, Ekkehard
Year of Publication 23.05.2024
Get full text
Year of Publication 23.05.2024
Patent
Bispecific T cell activating antigen binding molecules
WEINZIERL, Tina, BACAC, Marina, JAEGER, Christiane, HOSSE, Ralf, HOFER, Thomas, UMANA, Pablo, KLEIN, Christian, MOESSNER, Ekkehard
Year of Publication 09.05.2024
Get full text
Year of Publication 09.05.2024
Patent