The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons
Koren, Itay, Timms, Richard T., Kula, Tomasz, Xu, Qikai, Li, Mamie Z., Elledge, Stephen J.
Published in Cell (14.06.2018)
Published in Cell (14.06.2018)
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Journal Article
Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells
Tchasovnikarova, Iva A., Timms, Richard T., Matheson, Nicholas J., Wals, Kim, Antrobus, Robin, Göttgens, Berthold, Dougan, Gordon, Dawson, Mark A., Lehner, Paul J.
Published in Science (American Association for the Advancement of Science) (26.06.2015)
Published in Science (American Association for the Advancement of Science) (26.06.2015)
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Journal Article
Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2
Tchasovnikarova, Iva A, Timms, Richard T, Douse, Christopher H, Roberts, Rhys C, Dougan, Gordon, Kingston, Robert E, Modis, Yorgo, Lehner, Paul J
Published in Nature genetics (01.07.2017)
Published in Nature genetics (01.07.2017)
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Journal Article
ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex
Timms, Richard T., Tchasovnikarova, Iva A., Antrobus, Robin, Dougan, Gordon, Lehner, Paul J.
Published in Cell reports (Cambridge) (11.10.2016)
Published in Cell reports (Cambridge) (11.10.2016)
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Journal Article
Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions
Burr, Stephen P., Costa, Ana S.H., Grice, Guinevere L., Timms, Richard T., Lobb, Ian T., Freisinger, Peter, Dodd, Roger B., Dougan, Gordon, Lehner, Paul J., Frezza, Christian, Nathan, James A.
Published in Cell metabolism (08.11.2016)
Published in Cell metabolism (08.11.2016)
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Journal Article
Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
Douse, Christopher H, Bloor, Stuart, Liu, Yangci, Shamin, Maria, Tchasovnikarova, Iva A, Timms, Richard T, Lehner, Paul J, Modis, Yorgo
Published in Nature communications (13.02.2018)
Published in Nature communications (13.02.2018)
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Journal Article
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
Douse, Christopher H, Tchasovnikarova, Iva A, Timms, Richard T, Protasio, Anna V, Seczynska, Marta, Prigozhin, Daniil M, Albecka, Anna, Wagstaff, Jane, Williamson, James C, Freund, Stefan M V, Lehner, Paul J, Modis, Yorgo
Published in Nature communications (02.10.2020)
Published in Nature communications (02.10.2020)
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Journal Article
The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1
Menzies, Sam A, Volkmar, Norbert, van den Boomen, Dick Jh, Timms, Richard T, Dickson, Anna S, Nathan, James A, Lehner, Paul J
Published in eLife (13.12.2018)
Published in eLife (13.12.2018)
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Journal Article
Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase
Chen, Xinyan, Raiff, Anat, Li, Shanshan, Guo, Qiong, Zhang, Jiahai, Zhou, Hualin, Timms, Richard T, Yao, Xuebiao, Elledge, Stephen J, Koren, Itay, Zhang, Kaiming, Xu, Chao
Published in Nature communications (26.04.2024)
Published in Nature communications (26.04.2024)
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Journal Article
Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens
Timms, Richard T, Menzies, Sam A, Tchasovnikarova, Iva A, Christensen, Lea C, Williamson, James C, Antrobus, Robin, Dougan, Gordon, Ellgaard, Lars, Lehner, Paul J
Published in Nature communications (10.06.2016)
Published in Nature communications (10.06.2016)
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Journal Article
TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I
van den Boomen, Dick J. H., Timms, Richard T., Grice, Guinevere L., Stagg, Helen R., Skødt, Karsten, Dougan, Gordon, Nathan, James A., Lehner, Paul J.
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
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Journal Article
Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases
Timms, Richard T, Duncan, Lidia M, Tchasovnikarova, Iva A, Antrobus, Robin, Smith, Duncan L, Dougan, Gordon, Weekes, Michael P, Lehner, Paul J
Published in PLoS pathogens (01.11.2013)
Published in PLoS pathogens (01.11.2013)
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Journal Article
Gfi1 Expression Is Controlled by Five Distinct Regulatory Regions Spread over 100 Kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 Acting as Upstream Regulators in Early Hematopoietic Cells
Wilson, Nicola K., Timms, Richard T., Kinston, Sarah J., Cheng, Yi-Han, Oram, S. Helen, Landry, Josette-Renee, Mullender, Joanne, Ottersbach, Katrin, Gottgens, Berthold
Published in Molecular and Cellular Biology (01.08.2010)
Published in Molecular and Cellular Biology (01.08.2010)
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Journal Article
Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells
Duncan, Lidia M, Timms, Richard T, Zavodszky, Eszter, Cano, Florencia, Dougan, Gordon, Randow, Felix, Lehner, Paul J
Published in PloS one (22.06.2012)
Published in PloS one (22.06.2012)
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Journal Article
A glycine-specific N-degron pathway mediates the quality control of protein N -myristoylation
Timms, Richard T, Zhang, Zhiqian, Rhee, David Y, Harper, J Wade, Koren, Itay, Elledge, Stephen J
Published in Science (American Association for the Advancement of Science) (05.07.2019)
Published in Science (American Association for the Advancement of Science) (05.07.2019)
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Journal Article
The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes
Robbez-Masson, Luisa, Tie, Christopher H C, Conde, Lucia, Tunbak, Hale, Husovsky, Connor, Tchasovnikarova, Iva A, Timms, Richard T, Herrero, Javier, Lehner, Paul J, Rowe, Helen M
Published in Genome research (01.06.2018)
Published in Genome research (01.06.2018)
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Journal Article
Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability
Shimshon, Adi, Dahan, Karin, Israel-Gueta, Mor, Olmayev-Yaakobov, Diana, Timms, Richard T, Bekturova, Aizat, Makaros, Yaara, Elledge, Stephen J, Koren, Itay
Published in The Journal of cell biology (05.08.2024)
Published in The Journal of cell biology (05.08.2024)
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