Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3
Hudson, Brian D., Tikhonova, Irina G., Pandey, Sunil K., Ulven, Trond, Milligan, Graeme
Published in The Journal of biological chemistry (30.11.2012)
Published in The Journal of biological chemistry (30.11.2012)
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Investigating the Structure–Activity Relationship of 1,2,4-Triazine G‑Protein-Coupled Receptor 84 (GPR84) Antagonists
Mahindra, Amit, Jenkins, Laura, Marsango, Sara, Huggett, Mark, Huggett, Margaret, Robinson, Lindsay, Gillespie, Jonathan, Rajamanickam, Muralikrishnan, Morrison, Angus, McElroy, Stuart, Tikhonova, Irina G., Milligan, Graeme, Jamieson, Andrew G.
Published in Journal of medicinal chemistry (25.08.2022)
Published in Journal of medicinal chemistry (25.08.2022)
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Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis
Olatunji, Samir, Bowen, Katherine, Huang, Chia-Ying, Weichert, Dietmar, Singh, Warispreet, Tikhonova, Irina G., Scanlan, Eoin M., Olieric, Vincent, Caffrey, Martin
Published in Nature communications (12.07.2021)
Published in Nature communications (12.07.2021)
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Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases
De Marco Verissimo, Carolina, Jewhurst, Heather L, Tikhonova, Irina G, Urbanus, Rolf T, Maule, Aaron G, Dalton, John P, Cwiklinski, Krystyna
Published in PLoS neglected tropical diseases (01.08.2020)
Published in PLoS neglected tropical diseases (01.08.2020)
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Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor
Hudson, Brian D., Due-Hansen, Maria E., Christiansen, Elisabeth, Hansen, Anna Mette, Mackenzie, Amanda E., Murdoch, Hannah, Pandey, Sunil K., Ward, Richard J., Marquez, Rudi, Tikhonova, Irina G., Ulven, Trond, Milligan, Graeme
Published in The Journal of biological chemistry (14.06.2013)
Published in The Journal of biological chemistry (14.06.2013)
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A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor
Grundmann, Manuel, Tikhonova, Irina G., Hudson, Brian D., Smith, Nicola J., Mohr, Klaus, Ulven, Trond, Milligan, Graeme, Kenakin, Terry, Kostenis, Evi
Published in Cell chemical biology (17.03.2016)
Published in Cell chemical biology (17.03.2016)
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Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs
Hudson, Brian D., Christiansen, Elisabeth, Tikhonova, Irina G., Grundmann, Manuel, Kostenis, Evi, Adams, David R., Ulven, Trond, Milligan, Graeme
Published in The FASEB journal (01.12.2012)
Published in The FASEB journal (01.12.2012)
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Steered molecular dynamics simulations reveal critical residues for (un)binding of substrates, inhibitors and a product to the malarial M1 aminopeptidase
Moore, Daniel S, Brines, Conor, Jewhurst, Heather, Dalton, John P, Tikhonova, Irina G
Published in PLoS computational biology (01.10.2018)
Published in PLoS computational biology (01.10.2018)
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Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835
Krasavin, Mikhail, Lukin, Alexey, Bagnyukova, Daria, Zhurilo, Nikolay, Zahanich, Ihor, Zozulya, Sergey, Ihalainen, Jouni, Forsberg, Markus M., Lehtonen, Marko, Rautio, Jarkko, Moore, Daniel, Tikhonova, Irina G.
Published in Bioorganic & medicinal chemistry (01.11.2016)
Published in Bioorganic & medicinal chemistry (01.11.2016)
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Redox-dependent loss of flavin by mitochondria complex I is different in brain and heart
Yoval-Sánchez, Belem, Ansari, Fariha, James, Joel, Niatsetskaya, Zoya, Sosunov, Sergey, Filipenko, Peter, Tikhonova, Irina G., Ten, Vadim, Wittig, Ilka, Rafikov, Ruslan, Galkin, Alexander
Published in Redox biology (01.05.2022)
Published in Redox biology (01.05.2022)
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Discovery of Novel Agonists and Antagonists of the Free Fatty Acid Receptor 1 (FFAR1) Using Virtual Screening
Tikhonova, Irina G, Sum, Chi Shing, Neumann, Susanne, Engel, Stanislav, Raaka, Bruce M, Costanzi, Stefano, Gershengorn, Marvin C
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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Internalization and desensitization of the human glucose-dependent-insulinotropic receptor is affected by N-terminal acetylation of the agonist
Ismail, Sadek, Dubois-Vedrenne, Ingrid, Laval, Marie, Tikhonova, Irina G., D'Angelo, Romina, Sanchez, Claire, Clerc, Pascal, Gherardi, Marie-Julie, Gigoux, Véronique, Magnan, Remi, Fourmy, Daniel
Published in Molecular and cellular endocrinology (15.10.2015)
Published in Molecular and cellular endocrinology (15.10.2015)
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Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator
Smith, Nicola J, Ward, Richard J, Stoddart, Leigh A, Hudson, Brian D, Kostenis, Evi, Ulven, Trond, Morris, Joanne C, Tränkle, Christian, Tikhonova, Irina G, Adams, David R, Milligan, Graeme
Published in Molecular pharmacology (01.07.2011)
Published in Molecular pharmacology (01.07.2011)
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Identification of Residues Important for Agonist Recognition and Activation in GPR40
Sum, Chi Shing, Tikhonova, Irina G., Neumann, Susanne, Engel, Stanislav, Raaka, Bruce M., Costanzi, Stefano, Gershengorn, Marvin C.
Published in The Journal of biological chemistry (05.10.2007)
Published in The Journal of biological chemistry (05.10.2007)
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Bidirectional, Iterative Approach to the Structural Delineation of the Functional “Chemoprint” in GPR40 for Agonist Recognition
Tikhonova, Irina G, Sum, Chi Shing, Neumann, Susanne, Thomas, Craig J, Raaka, Bruce M, Costanzi, Stefano, Gershengorn, Marvin C
Published in Journal of medicinal chemistry (28.06.2007)
Published in Journal of medicinal chemistry (28.06.2007)
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