Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity: Design, Synthesis, and X-ray Cocrystal Structure
Canan Koch, Stacie S, Thoresen, Lars H, Tikhe, Jayashree G, Maegley, Karen A, Almassy, Robert J, Li, Jianke, Yu, Xiao-Hong, Zook, Scott E, Kumpf, Robert A, Zhang, Cathy, Boritzki, Theodore J, Mansour, Rena N, Zhang, Kanyin E, Ekker, Anne, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R, Webber, Stephen E, Hostomsky, Zdenek
Published in Journal of medicinal chemistry (07.11.2002)
Published in Journal of medicinal chemistry (07.11.2002)
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Design, Synthesis, and Evaluation of 3,4-Dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase
Tikhe, Jayashree G, Webber, Stephen E, Hostomsky, Zdenek, Maegley, Karen A, Ekkers, Anne, Li, Jianke, Yu, Xiao-Hong, Almassy, Robert J, Kumpf, Robert A, Boritzki, Theodore J, Zhang, Cathy, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R
Published in Journal of medicinal chemistry (21.10.2004)
Published in Journal of medicinal chemistry (21.10.2004)
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Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids
Dragovich, Peter S, Webber, Stephen E, Prins, Thomas J, Zhou, Ru, Marakovits, Joseph T, Tikhe, Jayashree G, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Ford, Clifford E, Brown, Edward L, Binford, Susan L, Meador, James W, Ferre, Rose Ann, Worland, Stephen T
Published in Bioorganic & medicinal chemistry letters (02.08.1999)
Published in Bioorganic & medicinal chemistry letters (02.08.1999)
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Journal Article
Design, Synthesis, and Evaluation of 3,4-Dihydro-2 H -[1,4]diazepino[6,7,1- hi ]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase
Tikhe, Jayashree G., Webber, Stephen E., Hostomsky, Zdenek, Maegley, Karen A., Ekkers, Anne, Li, Jianke, Yu, Xiao-Hong, Almassy, Robert J., Kumpf, Robert A., Boritzki, Theodore J., Zhang, Cathy, Calabrese, Chris R., Curtin, Nicola J., Kyle, Suzanne, Thomas, Huw D., Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T., Griffin, Roger J., Newell, David R.
Published in Journal of medicinal chemistry (01.10.2004)
Published in Journal of medicinal chemistry (01.10.2004)
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Complement Modulators and Related Methods
Blain, Jonathan C, Pezzati, Bemardo, Hildering, Andrew, Gallagher-Duval, Shawn, Tikhe, Jayashree G, Dhamnaskar, Ketki Ashok, Akgun, Burcin, Hale, Michael R, Ricardo, Alonso, Ma, Zhong, Geng, Bolin, LaPlaca, Derek M, Davoren, Jennifer, Tang, Guo-Qing, Vadysirisack, Douangsone D, Galullo, Vincent P, Diner, Colin, Cao, Qing, Treco, Douglas A, Sayegh, Camil, Pozzan, Alfonso, Sturino, Claudio, Jeanneret, Alexandria, Bertani, Barbara, Seyb, Kathleen, Youngsaye, Willmen Wing-Menn, MIcheli, Fabrizio, Siegert, Timothy Ryan, Lemire, Alex, Gong, Yongjin, Ashwell, Susan, Liu, Xiaorong, Xu, Wenqing, Hoarty, Michelle Denise, Belouin, Audrey, Stringer, Joseph R, Rajagopal, Vaishnavi
Year of Publication 13.04.2023
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Year of Publication 13.04.2023
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COMPLEMENT MODULATORS AND RELATED METHODS
BLAIN, Jonathan C, GALULLO, Vincent P, TRECO, Douglas A, HILDERING, Andrew, MA, Zhong, POZZAN, Alfonso, TIKHE, Jayashree G, AKGUN, Burcin, GONG, Yongjin, HALE, Michael R, SIEGERT, Timothy Ryan, TANG, Guo-Qing, YOUNGSAYE, Willmen Wing-Menn, HOARTY, Michelle Denise, BERTANI, Barbara, VADYSIRISACK, Douangsone D, LEMIRE, Alex, RICARDO, Alonso, BELOUIN, Audrey, GENG, Bolin, MICHELI, Fabrizio, GALLAGHER-DUVAL, Shawn, CAO, Qing, DHAMNASKAR, Ketki Ashok, LIU, Xiaorong, STURINO, Claudio, JEANNERET, Alexandria, DINER, Colin, PEZZATI, Bernardo, LAPLACA, Derek M, DAVOREN, Jennifer, SAYEGH, Camil, SEYB, Kathleen, XU, Wenqing, STRINGER, Joseph R, ASHWELL, Susan, RAJAGOPAL, Vaishnavi
Year of Publication 09.02.2022
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Year of Publication 09.02.2022
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COMPLEMENT MODULATORS AND RELATED METHODS
AKGUN, BURCIN, YOUNGSAYE, WILLMEN WING-MENN, SAYEGH, CAMIL, STURINO, CLAUDIO, BERTANI, BARBARA, HILDERING, ANDREW, BLAIN, JONATHAN C, XU, WENQING, GENG, BOLIN, LIU, XIAORONG, GALULLO, VINCENT P, DHAMNASKAR, KETKI ASHOK, MICHELI, FABRIZIO, TANG, GUO-QING, STRINGER, JOSEPH R, RAJAGOPAL, VAISHNAVI, GONG, YONGJIN, DINER, COLIN, SIEGERT, TIMOTHY RYAN, GALLAGHER-DUVAL, SHAWN, LAPLACA, DEREK M, TRECO, DOUGLAS A, SEYB, KATHLEEN, JEANNERET, ALEXANDRIA, HALE, MICHAEL R, POZZAN, ALFONSO, LEMIRE, ALEX, HOARTY, MICHELLE DENISE, CAO, QING, ASHWELL, SUSAN, DAVOREN, JENNIFER, TIKHE, JAYASHREE G, VADYSIRISACK, DOUANGSONE D, MA, ZHONG, BELOIN, AUDREY, PEZZATI, BERNARDO, RICARDO, ALONSO
Year of Publication 08.10.2020
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Year of Publication 08.10.2020
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COMPLEMENT MODULATORS AND RELATED METHODS
BLAIN, Jonathan C, GALULLO, Vincent P, TRECO, Douglas A, HILDERING, Andrew, MA, Zhong, POZZAN, Alfonso, TIKHE, Jayashree G, AKGUN, Burcin, GONG, Yongjin, HALE, Michael R, SIEGERT, Timothy Ryan, TANG, Guo-Qing, YOUNGSAYE, Willmen Wing-Menn, HOARTY, Michelle Denise, BERTANI, Barbara, VADYSIRISACK, Douangsone D, LEMIRE, Alex, RICARDO, Alonso, BELOUIN, Audrey, GENG, Bolin, MICHELI, Fabrizio, GALLAGHER-DUVAL, Shawn, CAO, Qing, DHAMNASKAR, Ketki Ashok, LIU, Xiaorong, STURINO, Claudio, JEANNERET, Alexandria, DINER, Colin, PEZZATI, Bernardo, LAPLACA, Derek M, DAVOREN, Jennifer, SAYEGH, Camil, SEYB, Kathleen, XU, Wenqing, STRINGER, Joseph R, ASHWELL, Susan, RAJAGOPAL, Vaishnavi
Year of Publication 08.10.2020
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Year of Publication 08.10.2020
Patent
Complement modulators and related methods
AKGUN, BURCIN, YOUNGSAYE, WILLMEN WING-MENN, SAYEGH, CAMIL, BERTANI, BARBARA, STURINO, CLAUDIO, HILDERING, ANDREW, XU, WEN-QING, BLAIN, JONATHAN C, GENG, BOLIN, LIU, XIAORONG, GALULLO, VINCENT P, DHAMNASKAR, KETKI ASHOK, MICHELI, FABRIZIO, TANG, GUO-QING, STRINGER, JOSEPH R, RAJAGOPAL, VAISHNAVI, DINER, COLIN, SIEGERT, TIMOTHY RYAN, GALLAGHER-DUVAL, SHAWN, LAPLACA, DEREK M, TRECO, DOUGLAS A, SEYB, KATHLEEN, GONG, YONG-JIN, JEANNERET, ALEXANDRIA, HALE, MICHAEL R, POZZAN, ALFONSO, BELOUIN, AUDREY, LEMIRE, ALEX, HOARTY, MICHELLE DENISE, CAO, QING, ASHWELL, SUSAN, DAVOREN, JENNIFER, TIKHE, JAYASHREE G, VADYSIRISACK, DOUANGSONE D, PEZZATI, BERNARDO, MA, ZHONG, RICARDO, ALONSO
Year of Publication 16.01.2021
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Year of Publication 16.01.2021
Patent
PENGHAMBAT-PENGHAMBAT TRISIKLIK DARI POLI (ADP-RIBOSE) POLIMESASE
STEPHEN E. WEBBER, JAYASHREE G. TIKHE, STACIE S. CANAN-KOCH, LARS H. THORESEN
Year of Publication 08.11.2001
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Year of Publication 08.11.2001
Patent
3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
KEPHART SUSAN E, DEAL JUDITH G, PARK JULIE Y, MCALPINE INDRAWAN J, TIKHE JAYASHREE G, JOHNSON MARY C, ROMINES WILLIAM H.III
Year of Publication 28.04.2005
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Year of Publication 28.04.2005
Patent
TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASES
CANAN-KOCH, STACIE S, TIKHE, JAYASHREE G, THORESEN, LARS H, WEBBER, STEPHEN E
Year of Publication 31.05.2002
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Year of Publication 31.05.2002
Patent
TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASES
EASTMAN, WALTER B, TIKHE, JAYASHREE G, MARAKOVITS, JOSEPH T, SKALITZKY, DONALD J, KUMPF, ARNOLD R, WEBBER, STEPHEN E
Year of Publication 31.03.2003
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Year of Publication 31.03.2003
Patent