The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
Chowdhury, Rasheduzzaman, Yeoh, Kar Kheng, Tian, Ya-Min, Hillringhaus, Lars, Bagg, Eleanor A, Rose, Nathan R, Leung, Ivanhoe K H, Li, Xuan S, Woon, Esther C Y, Yang, Ming, McDonough, Michael A, King, Oliver N, Clifton, Ian J, Klose, Robert J, Claridge, Timothy D W, Ratcliffe, Peter J, Schofield, Christopher J, Kawamura, Akane
Published in EMBO reports (01.05.2011)
Published in EMBO reports (01.05.2011)
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Journal Article
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
Cockman, Matthew E, Lippl, Kerstin, Tian, Ya-Min, Pegg, Hamish B, Figg, Jnr, William D, Abboud, Martine I, Heilig, Raphael, Fischer, Roman, Myllyharju, Johanna, Schofield, Christopher J, Ratcliffe, Peter J
Published in eLife (10.09.2019)
Published in eLife (10.09.2019)
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Journal Article
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
Chowdhury, Rasheduzzaman, Leung, Ivanhoe K H, Tian, Ya-Min, Abboud, Martine I, Ge, Wei, Domene, Carmen, Cantrelle, François-Xavier, Landrieu, Isabelle, Hardy, Adam P, Pugh, Christopher W, Ratcliffe, Peter J, Claridge, Timothy D W, Schofield, Christopher J
Published in Nature communications (26.08.2016)
Published in Nature communications (26.08.2016)
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Journal Article
Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer
Salama, Rafik, Masson, Norma, Simpson, Peter, Sciesielski, Lina Katrin, Sun, Min, Tian, Ya-Min, Ratcliffe, Peter John, Mole, David Robert
Published in PloS one (11.08.2015)
Published in PloS one (11.08.2015)
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Journal Article
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain
Chan, Mun Chiang, Atasoylu, Onur, Hodson, Emma, Tumber, Anthony, Leung, Ivanhoe K H, Chowdhury, Rasheduzzaman, Gómez-Pérez, Verónica, Demetriades, Marina, Rydzik, Anna M, Holt-Martyn, James, Tian, Ya-Min, Bishop, Tammie, Claridge, Timothy D W, Kawamura, Akane, Pugh, Christopher W, Ratcliffe, Peter J, Schofield, Christopher J
Published in PloS one (06.07.2015)
Published in PloS one (06.07.2015)
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Journal Article
Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors
Tian, Ya-Min, Yeoh, Kar Kheng, Lee, Myung Kyu, Eriksson, Tuula, Kessler, Benedikt M., Kramer, Holger B., Edelmann, Mariola J., Willam, Carsten, Pugh, Christopher W., Schofield, Christopher J., Ratcliffe, Peter J.
Published in The Journal of biological chemistry (15.04.2011)
Published in The Journal of biological chemistry (15.04.2011)
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Journal Article
The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
Masson, Norma, Singleton, Rachelle S, Sekirnik, Rok, Trudgian, David C, Ambrose, Lucy J, Miranda, Melroy X, Tian, Ya-Min, Kessler, Benedikt M, Schofield, Christopher J, Ratcliffe, Peter J
Published in EMBO reports (01.03.2012)
Published in EMBO reports (01.03.2012)
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Journal Article
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors
Demetriades, Marina, Leung, Ivanhoe K. H., Chowdhury, Rasheduzzaman, Chan, Mun Chiang, McDonough, Michael A., Yeoh, Kar Kheng, Tian, Ya-Min, Claridge, Timothy D. W., Ratcliffe, Peter J., Woon, Esther C. Y., Schofield, Christopher J.
Published in Angewandte Chemie (International ed.) (02.07.2012)
Published in Angewandte Chemie (International ed.) (02.07.2012)
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Journal Article
Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor
Appelhoff, Rebecca J., Tian, Ya-Min, Raval, Raju R., Turley, Helen, Harris, Adrian L., Pugh, Christopher W., Ratcliffe, Peter J., Gleadle, Jonathan M.
Published in The Journal of biological chemistry (10.09.2004)
Published in The Journal of biological chemistry (10.09.2004)
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Journal Article
Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family
Hewitson, Kirsty S., McNeill, Luke A., Riordan, Madeline V., Tian, Ya-Min, Bullock, Alex N., Welford, Richard W., Elkins, Jonathan M., Oldham, Neil J., Bhattacharya, Shoumo, Gleadle, Jonathan M., Ratcliffe, Peter J., Pugh, Christopher W., Schofield, Christopher J.
Published in The Journal of biological chemistry (19.07.2002)
Published in The Journal of biological chemistry (19.07.2002)
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Journal Article
Orelabrutinib for the treatment of relapsed or refractory MCL: a phase 1/2, open-label, multicenter, single-arm study
Deng, Li-Juan, Zhou, Ke-Shu, Liu, Li-Hong, Zhang, Ming-Zhi, Li, Zhi-Ming, Ji, Chun-Yan, Xu, Wei, Liu, Ting, Xu, Bing, Wang, Xin, Gao, Su-Jun, Zhang, Hui-Lai, Hu, Yu, Li, Yan, Cheng, Ying, Yang, Hai-Yan, Cao, Jun-Ning, Zhu, Zun-Min, Hu, Jian-Da, Zhang, Wei, Jing, Hong-Mei, Ding, Kai-Yang, Zhang, Xiang-Yang, Zhao, Ren-Bin, Zhang, Bin, Tian, Ya-Min, Song, Yong-Ping, Song, Yu-Qin, Zhu, Jun
Published in Blood advances (22.08.2023)
Published in Blood advances (22.08.2023)
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Journal Article
Genetic Analysis of the Role of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-inducible Factor (HIF) in Regulating HIF Transcriptional Target Genes
Stolze, Ineke P., Tian, Ya-Min, Appelhoff, Rebecca J., Turley, Helen, Wykoff, Charles C., Gleadle, Jonathan M., Ratcliffe, Peter J.
Published in The Journal of biological chemistry (08.10.2004)
Published in The Journal of biological chemistry (08.10.2004)
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Journal Article
Determination and comparison of specific activity of the HIF-prolyl hydroxylases
Tuckerman, Jason R., Zhao, Yuguang, Hewitson, Kirsty S., Tian, Ya-Min, Pugh, Christopher W., Ratcliffe, Peter J., Mole, David R.
Published in FEBS letters (08.10.2004)
Published in FEBS letters (08.10.2004)
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Journal Article
Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells
Tian, Ya-Min, Holdship, Philip, To, Trang Quynh, Ratcliffe, Peter J., Keeley, Thomas P.
Published in The Journal of biological chemistry (01.09.2023)
Published in The Journal of biological chemistry (01.09.2023)
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Journal Article
Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
Mazzone, Massimiliano, Dettori, Daniela, Leite de Oliveira, Rodrigo, Loges, Sonja, Schmidt, Thomas, Jonckx, Bart, Tian, Ya-Min, Lanahan, Anthony A., Pollard, Patrick, Ruiz de Almodovar, Carmen, De Smet, Frederik, Vinckier, Stefan, Aragonés, Julián, Debackere, Koen, Luttun, Aernout, Wyns, Sabine, Jordan, Benedicte, Pisacane, Alberto, Gallez, Bernard, Lampugnani, Maria Grazia, Dejana, Elisabetta, Simons, Michael, Ratcliffe, Peter, Maxwell, Patrick, Carmeliet, Peter
Published in Cell (06.03.2009)
Published in Cell (06.03.2009)
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Journal Article
Peptide Blockade of HIFα Degradation Modulates Cellular Metabolism and Angiogenesis
Willam, Carsten, Masson, Norma, Tian, Ya-Min, Mahmood, S. Aleema, Wilson, Michael I., Bicknell, Roy, Eckardt, Kai-Uwe, Maxwell, Patrick H., Ratcliffe, Peter J., Pugh, Christopher W.
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2002)
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Journal Article
Mutation Analysis of Hypoxia-inducible Factors HIF1A and HIF2A in Renal Cell Carcinoma
Morris, Mark R, Hughes, David J, Tian, Ya-Min, Ricketts, Christopher J, Lau, Kah Weng, Gentle, Dean, Shuib, Salwati, Serrano-Fernandez, Pablo, Lubinski, Jan, Wiesener, Michael S, Pugh, Christopher W, Latif, Farida, Ratcliffe, Peter J, Maher, Eamonn R
Published in Anticancer research (01.11.2009)
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Published in Anticancer research (01.11.2009)
Journal Article
Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia
Camps, Carme, Saini, Harpreet K, Mole, David R, Choudhry, Hani, Reczko, Martin, Guerra-Assunção, José Afonso, Tian, Ya-Min, Buffa, Francesca M, Harris, Adrian L, Hatzigeorgiou, Artemis G, Enright, Anton J, Ragoussis, Jiannis
Published in Molecular cancer (11.02.2014)
Published in Molecular cancer (11.02.2014)
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Journal Article
The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin
Masson, Norma, Appelhoff, Rebecca J., Tuckerman, Jason R., Tian, Ya-min, Demol, Hans, Puype, Magda, Vandekerckhove, Joel, Ratcliffe, Peter J., Pugh, Christopher W.
Published in FEBS letters (16.07.2004)
Published in FEBS letters (16.07.2004)
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Journal Article
Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases
Chowdhury, Rasheduzzaman, Candela-Lena, José Ignacio, Chan, Mun Chiang, Greenald, David Jeremy, Yeoh, Kar Kheng, Tian, Ya-Min, McDonough, Michael A, Tumber, Anthony, Rose, Nathan R, Conejo-Garcia, Ana, Demetriades, Marina, Mathavan, Sinnakaruppan, Kawamura, Akane, Lee, Myung Kyu, van Eeden, Freek, Pugh, Christopher W, Ratcliffe, Peter J, Schofield, Christopher J
Published in ACS chemical biology (19.07.2013)
Published in ACS chemical biology (19.07.2013)
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Journal Article