Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma
Capparelli, Claudia, Purwin, Timothy J., Glasheen, McKenna, Caksa, Signe, Tiago, Manoela, Wilski, Nicole, Pomante, Danielle, Rosenbaum, Sheera, Nguyen, Mai Q., Cai, Weijia, Franco-Barraza, Janusz, Zheng, Richard, Kumar, Gaurav, Chervoneva, Inna, Shimada, Ayako, Rebecca, Vito W., Snook, Adam E., Hookim, Kim, Xu, Xiaowei, Cukierman, Edna, Herlyn, Meenhard, Aplin, Andrew E.
Published in Nature communications (16.03.2022)
Published in Nature communications (16.03.2022)
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Raptinal Induces Gasdermin E-Dependent Pyroptosis in Naïve and Therapy-Resistant Melanoma
Vernon, Megane, Wilski, Nicole A, Kotas, Daniel, Cai, Weijia, Pomante, Danielle, Tiago, Manoela, Alnemri, Emad S, Aplin, Andrew E
Published in Molecular cancer research (02.12.2022)
Published in Molecular cancer research (02.12.2022)
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A Genome-Wide Screen Identifies PDPK1 as a Target to Enhance the Efficacy of MEK1/2 Inhibitors in NRAS Mutant Melanoma
Cai, Weijia, Nguyen, Mai Q, Wilski, Nicole A, Purwin, Timothy J, Vernon, Mégane, Tiago, Manoela, Aplin, Andrew E
Published in Cancer research (Chicago, Ill.) (18.07.2022)
Published in Cancer research (Chicago, Ill.) (18.07.2022)
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CADM1 is a TWIST1-regulated suppressor of invasion and survival
Hartsough, Edward J., Weiss, Michele B., Heilman, Shea A., Purwin, Timothy J., Kugel, Curtis H., Rosenbaum, Sheera R., Erkes, Dan A., Tiago, Manoela, HooKim, Kim, Chervoneva, Inna, Aplin, Andrew E.
Published in Cell death & disease (25.03.2019)
Published in Cell death & disease (25.03.2019)
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Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma
Han, Anna, Chua, Vivian, Baqai, Usman, Purwin, Timothy J., Bechtel, Nelisa, Hunter, Emily, Tiago, Manoela, Seifert, Erin, Speicher, David W., Schug, Zachary T., Harbour, J. William, Aplin, Andrew E.
Published in Oncogene (18.02.2022)
Published in Oncogene (18.02.2022)
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Targeting BRD/BET proteins inhibits adaptive kinome upregulation and enhances the effects of BRAF/MEK inhibitors in melanoma
Tiago, Manoela, Capparelli, Claudia, Erkes, Dan A., Purwin, Timothy J., Heilman, Shea A., Berger, Adam C., Davies, Michael A., Aplin, Andrew E.
Published in British journal of cancer (17.03.2020)
Published in British journal of cancer (17.03.2020)
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The next‐generation BET inhibitor, PLX51107, delays melanoma growth in a CD8‐mediated manner
Erkes, Dan A., Field, Conroy O., Capparelli, Claudia, Tiago, Manoela, Purwin, Timothy J., Chervoneva, Inna, Berger, Adam C., Hartsough, Edward J., Villanueva, Jessie, Aplin, Andrew E.
Published in Pigment cell and melanoma research (01.09.2019)
Published in Pigment cell and melanoma research (01.09.2019)
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Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth
Han, Anna, Mukha, Dzmitry, Chua, Vivian, Purwin, Timothy J, Tiago, Manoela, Modasia, Bhavik, Baqai, Usman, Aumiller, Jenna L, Bechtel, Nelisa, Hunter, Emily, Danielson, Meggie, Terai, Mizue, Wedegaertner, Philip B, Sato, Takami, Landreville, Solange, Davies, Michael A, Kurtenbach, Stefan, Harbour, J William, Schug, Zachary T, Aplin, Andrew E
Published in Cancers (30.06.2023)
Published in Cancers (30.06.2023)
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Apoptosis through Bcl-2/Bax and cleaved caspase up-regulation in melanoma treated by boron neutron capture therapy
Faião-Flores, Fernanda, Coelho, Paulo Rogério Pinto, Toledo Arruda-Neto, João Dias, Maria-Engler, Silvya Stuchi, Tiago, Manoela, Capelozzi, Vera Luiza, Giorgi, Ricardo Rodrigues, Maria, Durvanei Augusto
Published in PloS one (20.03.2013)
Published in PloS one (20.03.2013)
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A natural bacterial-derived product, the metalloprotease arazyme, inhibits metastatic murine melanoma by inducing MMP-8 cross-reactive antibodies
Pereira, Felipe V, Ferreira-Guimarães, Carla A, Paschoalin, Thaysa, Scutti, Jorge A B, Melo, Filipe M, Silva, Luis S, Melo, Amanda C L, Silva, Priscila, Tiago, Manoela, Matsuo, Alisson L, Juliano, Luiz, Juliano, Maria A, Carmona, Adriana K, Travassos, Luiz R, Rodrigues, Elaine G
Published in PloS one (01.04.2014)
Published in PloS one (01.04.2014)
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Proteasome inhibition and ROS generation by 4-nerolidylcatechol induces melanoma cell death
Brohem, Carla A., Massaro, Renato R., Tiago, Manoela, Marinho, Camila E., Jasiulionis, Miriam G., de Almeida, Rebeca L., Rivelli, Diogo P., Albuquerque, Renata C., de Oliveira, Tiago F., de Melo Loureiro, Ana P., Okada, Sabrina, Soengas, María S., de Moraes Barros, Silvia B., Maria-Engler, Silvya S.
Published in Pigment cell and melanoma research (01.05.2012)
Published in Pigment cell and melanoma research (01.05.2012)
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Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ -Driven Uveal Melanoma
Paradis, Justine S, Acosta, Monica, Saddawi-Konefka, Robert, Kishore, Ayush, Gomes, Frederico, Arang, Nadia, Tiago, Manoela, Coma, Silvia, Lubrano, Simone, Wu, Xingyu, Ford, Kyle, Day, Chi-Ping, Merlino, Glenn, Mali, Prashant, Pachter, Jonathan A, Sato, Takami, Aplin, Andrew E, Gutkind, J Silvio
Published in Clinical cancer research (01.06.2021)
Published in Clinical cancer research (01.06.2021)
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SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects
Rosenbaum, Sheera R., Tiago, Manoela, Caksa, Signe, Capparelli, Claudia, Purwin, Timothy J., Kumar, Gaurav, Glasheen, McKenna, Pomante, Danielle, Kotas, Daniel, Chervoneva, Inna, Aplin, Andrew E.
Published in Cell reports (Cambridge) (07.12.2021)
Published in Cell reports (Cambridge) (07.12.2021)
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Abstract 2986: NR2F1 underlies persistence of residual disease in melanoma
Tiago, Manoela, Teh, Jessica L., Purwin, Timothy J., Cai, Weijia, Hollingworth, Connor, Lopez-Anton, Melisa, Aguirre-Ghiso, Julio A., Aplin, Andrew E.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Vemurafenib resistance increases melanoma invasiveness and modulates the tumor microenvironment by MMP-2 upregulation
Sandri, Silvana, Faião-Flores, Fernanda, Tiago, Manoela, Pennacchi, Paula Comune, Massaro, Renato Ramos, Alves-Fernandes, Débora Kristina, Berardinelli, Gustavo Noriz, Evangelista, Adriane Feijó, de Lima Vazquez, Vinicius, Reis, Rui Manuel, Maria-Engler, Silvya Stuchi
Published in Pharmacological research (01.09.2016)
Published in Pharmacological research (01.09.2016)
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Connections of annexin A1 and translocator protein-18 kDa on toll like receptor stimulated BV-2 cells
Pantaleão, Lorena, Rocha, Gustavo Henrique Oliveira, Reutelingsperger, Chris, Tiago, Manoela, Maria-Engler, Silvya Stucchi, Solito, Egle, Farsky, Sandra P.
Published in Experimental cell research (15.06.2018)
Published in Experimental cell research (15.06.2018)
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Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ -Driven Uveal Melanoma
Paradis, Justine S, Acosta, Monica, Saddawi-Konefka, Robert, Kishore, Ayush, Lubrano, Simone, Gomes, Frederico, Arang, Nadia, Tiago, Manoela, Coma, Silvia, Wu, Xingyu, Ford, Kyle, Day, Chi-Ping, Merlino, Glenn, Mali, Prashant, Pachter, Jonathan A, Sato, Takami, Aplin, Andrew E, Gutkind, J Silvio
Published in Clinical cancer research (15.08.2021)
Published in Clinical cancer research (15.08.2021)
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Journal Article
Abstract 40: Targeting SOX10-deficient cells to reduce resistance to targeted therapy in melanoma
Capparelli, Claudia, Purwin, Timothy J., Tiago, Manoela, Wilski, Nicole, Pomante, Danielle, Glasheen, McKenna, Rosenbaum, Sheera, Nguyen, Mai Q., Cai, Weijia, Zheng, Richard, Kumar, Gaurav, Chervoneva, Inna, Shimada, Ayako, Snook, Adam E., Fortina, Paolo, Xu, Xiaowei, Hookim, Kim, Cukierman, Edna, Davies, Michael A., Herlyn, Meenhard, Aplin, Andrew E.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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