Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA-Interactive Agent with Highly Efficient Cross-Linking Ability and Potent Cytotoxicity
Gregson, Stephen J, Howard, Philip W, Hartley, John A, Brooks, Natalie A, Adams, Lesley J, Jenkins, Terence C, Kelland, Lloyd R, Thurston, David E
Published in Journal of medicinal chemistry (01.03.2001)
Published in Journal of medicinal chemistry (01.03.2001)
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Preclinical pharmacology of the pyrrolobenzodiazepine (PBD) monomer DRH-417 (NSC 709119)
Burger, A M, Loadman, P M, Thurston, D E, Schultz, R, Fiebig, H H, Bibby, M C
Published in Journal of chemotherapy (Florence) (01.02.2007)
Published in Journal of chemotherapy (Florence) (01.02.2007)
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Synthesis, in Vitro Antiproliferative Activity, and DNA-Binding Properties of Hybrid Molecules Containing Pyrrolo[2,1-c][1,4]benzodiazepine and Minor-Groove-Binding Oligopyrrole Carriers
Baraldi, Pier Giovanni, Balboni, Gianfranco, Cacciari, Barbara, Guiotto, Andrea, Manfredini, Stefano, Romagnoli, Romeo, Spalluto, Giampiero, Thurston, David E, Howard, Philip W, Bianchi, Nicoletta, Rutigliano, Cristina, Mischiati, Carlo, Gambari, Roberto
Published in Journal of medicinal chemistry (16.12.1999)
Published in Journal of medicinal chemistry (16.12.1999)
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Effect of A-Ring Modifications on the DNA-Binding Behavior and Cytotoxicity of Pyrrolo[2,1-c][1,4]benzodiazepines
Thurston, David E, Bose, D. Subhas, Howard, Philip W, Jenkins, Terence C, Leoni, Alberto, Baraldi, Pier G, Guiotto, Andrea, Cacciari, Barbara, Kelland, Lloyd R, Foloppe, Marie-Paule, Rault, Sylvain
Published in Journal of medicinal chemistry (03.06.1999)
Published in Journal of medicinal chemistry (03.06.1999)
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Design, Synthesis, and Evaluation of a Novel Sequence-Selective Epoxide-Containing DNA Cross-Linking Agent Based on the Pyrrolo[2,1-c][1,4]benzodiazepine System
Wilson, Stuart C, Howard, Philip W, Forrow, Stephen M, Hartley, John A, Adams, Lesley J, Jenkins, Terence C, Kelland, Lloyd R, Thurston, David E
Published in Journal of medicinal chemistry (07.10.1999)
Published in Journal of medicinal chemistry (07.10.1999)
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Effect of C2- exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1- c][1,4]benzodiazepines
Gregson, Stephen J., Howard, Philip W., Corcoran, Kathryn E., Barcella, Simona, Yasin, Maqsood M., Hurst, Abigail A., Jenkins, Terence C., Kelland, Lloyd R., Thurston, David E.
Published in Bioorganic & medicinal chemistry letters (21.08.2000)
Published in Bioorganic & medicinal chemistry letters (21.08.2000)
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Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells
Pepper, C, Lowe, H, Fegan, C, Thurieau, C, Thurston, D E, Hartley, J A, Delavault, P
Published in British journal of cancer (10.07.2007)
Published in British journal of cancer (10.07.2007)
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Effect of C2/C3- endo unsaturation on the cytotoxicity and dna-binding reactivity of pyrrolo[2,1- c][1,4]benzodiazepines
Gregson, Stephen J., Howard, Philip W., Barcella, Simona, Nakamya, Anthonia, Jenkins, Terence C., Kelland, Lloyd R., Thurston, David E.
Published in Bioorganic & medicinal chemistry letters (21.08.2000)
Published in Bioorganic & medicinal chemistry letters (21.08.2000)
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A quantitative assay to measure the relative DNA-binding affinity of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour antibiotics based on the inhibition of restriction endonuclease BamhI
Puvvada, Madhu S., Hartley, John A., Jenkins, Terence C., Thurston, David E.
Published in Nucleic acids research (11.08.1993)
Published in Nucleic acids research (11.08.1993)
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Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid
Baraldi, Pier Giovanni, Cacciari, Barbara, Guiotto, Andrea, Leoni, Alberto, Romagnoli, Romeo, Spalluto, Giampiero, Mongelli, Nicola, Howard, Philip W., Thurston, David E., Bianchi, Nicoletta, Gambari, Roberto
Published in Bioorganic & medicinal chemistry letters (03.11.1998)
Published in Bioorganic & medicinal chemistry letters (03.11.1998)
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Tetracycline analogues with a selective inhibitory effect on HIF-1α
Bendiabdellah, Y., Rahman, K. M., Uranchimeg, B., Nahar, K. S., Antonow, D., Shoemaker, R. H., Melillo, G., Zinzalla, G., Thurston, D. E.
Published in MedChemComm (2014)
Published in MedChemComm (2014)
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