Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
McCabe, Michael T, Graves, Alan P, Ganji, Gopinath, Diaz, Elsie, Halsey, Wendy S, Jiang, Yong, Smitheman, Kimberly N, Ott, Heidi M, Pappalardi, Melissa B, Allen, Kimberly E, Chen, Stephanie B, Della Pietra, Anthony III, Dul, Edward, Hughes, Ashley M, Gilbert, Seth A, Thrall, Sara H, Tummino, Peter J, Kruger, Ryan G, Brandt, Martin, Schwartz, Benjamin, Creasy, Caretha L
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
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Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36
Poulin, Myles B., Schneck, Jessica L., Matico, Rosalie E., McDevitt, Patrick J., Huddleston, Michael J., Hou, Wangfang, Johnson, Neil W., Thrall, Sara H., Meek, Thomas D., Schramm, Vern L.
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2016)
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Mutant IDH1 Enhances the Production of 2‑Hydroxyglutarate Due to Its Kinetic Mechanism
Rendina, Alan R, Pietrak, Beth, Smallwood, Angela, Zhao, Huizhen, Qi, Hongwei, Quinn, Chad, Adams, Nicholas D, Concha, Nestor, Duraiswami, Chaya, Thrall, Sara H, Sweitzer, Sharon, Schwartz, Benjamin
Published in Biochemistry (Easton) (02.07.2013)
Published in Biochemistry (Easton) (02.07.2013)
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Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens
Diaz, Elsie, Machutta, Carl A, Chen, Stephanie, Jiang, Yong, Nixon, Christopher, Hofmann, Glenn, Key, Danielle, Sweitzer, Sharon, Patel, Mehul, Wu, Zining, Creasy, Caretha L, Kruger, Ryan G, LaFrance, Louis, Verma, Sharad K, Pappalardi, Melissa B, Le, Baochau, Van Aller, Glenn S, McCabe, Michael T, Tummino, Peter J, Pope, Andrew J, Thrall, Sara H, Schwartz, Benjamin, Brandt, Martin
Published in Journal of biomolecular screening (01.12.2012)
Published in Journal of biomolecular screening (01.12.2012)
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The Amino-Acid Substituents of Dipeptide Substrates of Cathepsin C Can Determine the Rate-Limiting Steps of Catalysis
Rubach, Jon K, Cui, Guanglei, Schneck, Jessica L, Taylor, Amy N, Zhao, Baoguang, Smallwood, Angela, Nevins, Neysa, Wisnoski, David, Thrall, Sara H, Meek, Thomas D
Published in Biochemistry (Easton) (25.09.2012)
Published in Biochemistry (Easton) (25.09.2012)
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A Simple Assay for Detection of Small-Molecule Redox Activity
Lor, Leng A., Schneck, Jessica, McNulty, Dean E., Diaz, Elsie, Brandt, Martin, Thrall, Sara H., Schwartz, Benjamin
Published in Journal of biomolecular screening (01.09.2007)
Published in Journal of biomolecular screening (01.09.2007)
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Chemical Mechanism of a Cysteine Protease, Cathepsin C, As Revealed by Integration of both Steady-State and Pre-Steady-State Solvent Kinetic Isotope Effects
Schneck, Jessica L, Villa, James P, McDevitt, Patrick, McQueney, Michael S, Thrall, Sara H, Meek, Thomas D
Published in Biochemistry (Easton) (19.08.2008)
Published in Biochemistry (Easton) (19.08.2008)
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Perspectives on the discovery of small-molecule modulators for epigenetic processes
Lu, Quinn, Quinn, Amy M, Patel, Mehul P, Semus, Simon F, Graves, Alan P, Bandyopadhyay, Deepak, Pope, Andrew J, Thrall, Sara H
Published in Journal of biomolecular screening (01.06.2012)
Published in Journal of biomolecular screening (01.06.2012)
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Kinetic Mechanism and Rate-Limiting Steps of Focal Adhesion Kinase-1
Schneck, Jessica L, Briand, Jacques, Chen, Stephanie, Lehr, Ruth, McDevitt, Patrick, Zhao, Baoguang, Smallwood, Angela, Concha, Nestor, Oza, Khyati, Kirkpatrick, Robert, Yan, Kang, Villa, James P, Meek, Thomas D, Thrall, Sara H
Published in Biochemistry (Easton) (24.08.2010)
Published in Biochemistry (Easton) (24.08.2010)
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Understanding the Origins of Time-Dependent Inhibition by Polypeptide Deformylase Inhibitors
Totoritis, Rachel, Duraiswami, Chaya, Taylor, Amy N, Kerrigan, John J, Campobasso, Nino, Smith, Katherine J, Ward, Paris, King, Bryan W, Murrayz-Thompson, Monique, Jones, Amber D, Van Aller, Glenn S, Aubart, Kelly M, Zalacain, Magdalena, Thrall, Sara H, Meek, Thomas D, Schwartz, Benjamin
Published in Biochemistry (Easton) (09.08.2011)
Published in Biochemistry (Easton) (09.08.2011)
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Kinetic and Chemical Mechanisms of the fabG-Encoded Streptococcus pneumoniae β-Ketoacyl-ACP Reductase
Patel, Mehul P, Liu, Wu-Schyong, West, Joshua, Tew, David, Meek, Thomas D, Thrall, Sara H
Published in Biochemistry (Easton) (20.12.2005)
Published in Biochemistry (Easton) (20.12.2005)
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Amino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors
Evans, Karen A., Li, Yue H., Coppo, Frank T., Graybill, Todd L., Cichy-Knight, Maria, Patel, Mehul, Gale, Jennifer, Li, Hu, Thrall, Sara H., Tew, David, Tavares, Francis, Thomson, Stephen A., Weiel, James E., Boucheron, Joyce A., Clancy, Daphne C., Epperly, Andrea H., Golden, Pamela L.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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A High-Throughput Screen Measuring Ubiquitination of p53 by Human mdm2
Murray, Monique F., Jurewicz, Anthony J., Martin, John D., Ho, Thau F., Zhang, Hong, Johanson, Kyung O., Kirkpatrick, Robert B., Ma, Jianhong, Lor, Leng A., Thrall, Sara H., Schwartz, Benjamin
Published in Journal of biomolecular screening (01.12.2007)
Published in Journal of biomolecular screening (01.12.2007)
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Evaluation of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Primer tRNA Binding by Fluorescence Spectroscopy: Specificity and Comparison to Primer/Template Binding
Thrall, Sara H, Reinstein, Jochen, Wöhrl, Birgitta M, Goody, Roger S
Published in Biochemistry (Easton) (09.04.1996)
Published in Biochemistry (Easton) (09.04.1996)
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Determination of the Nucleotide Binding Site within Clostridium symbiosum Pyruvate Phosphate Dikinase by Photoaffinity Labeling, Site-Directed Mutagenesis, and Structural Analysis
McGuire, Marielena, Carroll, Lawrence J, Yankie, Linda, Thrall, Sara H, Dunaway-Mariano, Debra, Herzberg, Osnat, Jayaram, Beby, Haley, Boyd H
Published in Biochemistry (Easton) (02.07.1996)
Published in Biochemistry (Easton) (02.07.1996)
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Substrate Binding Domains in Pyruvate Phosphate Dikinase
Carroll, Lawrence J, Xu, Yuan, Thrall, Sara H, Martin, Brian M, Dunaway-Mariano, Debra
Published in Biochemistry (Easton) (08.02.1994)
Published in Biochemistry (Easton) (08.02.1994)
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Kinetic Analysis of Four HIV-1 Reverse Transcriptase Enzymes Mutated in the Primer Grip Region of p66
Wöhrl, Birgitta M., Krebs, Ruth, Thrall, Sara H., Le Grice, Stuart F.J., Scheidig, Axel J., Goody, Roger S.
Published in The Journal of biological chemistry (11.07.1997)
Published in The Journal of biological chemistry (11.07.1997)
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