"Cytokine Storm" in the Phase I Trial of Monoclonal Antibody TGN1412: Better Understanding the Causes to Improve PreClinical Testing of Immunotherapeutics
Stebbings, Richard, Findlay, Lucy, Edwards, Cherry, Eastwood, David, Bird, Chris, North, David, Mistry, Yogesh, Dilger, Paula, Liefooghe, Emily, Cludts, Isabelle, Fox, Bernard, Tarrant, Gill, Robinson, Jane, Meager, Tony, Dolman, Carl, Thorpe, Susan J, Bristow, Adrian, Wadhwa, Meenu, Thorpe, Robin, Poole, Stephen
Published in Journal of Immunology (01.09.2007)
Published in Journal of Immunology (01.09.2007)
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Journal Article
How predictive are in vitro assays for cytokine release syndrome in vivo? A comparison of methods reveals worrying differences in sensitivity and frequency of response
Thorpe, Susan J., Stebbings, Richard, Findlay, Lucy, Eastwood, David, Poole, Stephen, Thorpe, Robin
Published in Cytokine (Philadelphia, Pa.) (01.10.2013)
Published in Cytokine (Philadelphia, Pa.) (01.10.2013)
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Journal Article
Severity of the TGN1412 trial disaster cytokine storm correlated with IL‐2 release
Eastwood, David, Bird, Chris, Dilger, Paula, Hockley, Jason, Findlay, Lucy, Poole, Stephen, Thorpe, Susan J., Wadhwa, Meenu, Thorpe, Robin, Stebbings, Richard
Published in British journal of clinical pharmacology (01.08.2013)
Published in British journal of clinical pharmacology (01.08.2013)
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Journal Article
Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo
Parren, Paul W H I, Labrijn, Aran F, Buijsse, Antonio Ortiz, van den Bremer, Ewald T J, Verwilligen, Annemiek Y W, Bleeker, Wim K, Thorpe, Susan J, Killestein, Joep, Polman, Chris H, Aalberse, Rob C, Schuurman, Janine, van de Winkel, Jan G J
Published in Nature biotechnology (01.08.2009)
Published in Nature biotechnology (01.08.2009)
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Journal Article
An International Standard for holotranscobalamin (holoTC): international collaborative study to assign a holoTC value to the International Standard for vitamin B12 and serum folate
Thorpe, Susan J., Rigsby, Peter, Roberts, Graham, Lee, Anne, Hamilton, Malcolm, Craig, David
Published in Clinical chemistry and laboratory medicine (01.09.2016)
Published in Clinical chemistry and laboratory medicine (01.09.2016)
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Journal Article
A WHO Reference Reagent for the Serum Transferrin Receptor (sTfR): international collaborative study to evaluate a recombinant soluble transferrin receptor preparation
Thorpe, Susan J., Heath, Alan, Sharp, Giles, Cook, James, Ellis, Richard, Worwood, Mark
Published in Clinical chemistry and laboratory medicine (01.06.2010)
Published in Clinical chemistry and laboratory medicine (01.06.2010)
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Journal Article
Biomarkers of folate status in NHANES: a roundtable summary
YETLEY, Elizabeth A, PFEIFFER, Christine M, RANDY CURTIN, L, DURAZO-ARVIZU, Ramón A, ECKFELDT, John H, GREEN, Ralph, GREGORY, Jesse F, HOOFNAGLE, Andrew N, JACOBSEN, Donald W, JACQUES, Paul F, MOLLOY, Anne M, MASSARO, Joseph, PHINNEY, Karen W, MILLS, James L, NEXO, Ebba, RADER, Jeanne I, SELHUB, Jacob, SEMPOS, Christopher, SHANE, Barry, PATRICK STOVER, Sally Stabler, TAMURA, Tsunenobu, TEDSTONE, Alison, THORPE, Susan J, FAZILI, Zia, COATES, Paul M, JOHNSON, Clifford L, PICCIANO, Mary Frances, LACHER, David A, BAILEY, Regan L, BLACKMORE, Sheena, BOCK, Jay L, BRODY, Lawrence C, CARMEL, Ralph
Published in The American journal of clinical nutrition (01.07.2011)
Published in The American journal of clinical nutrition (01.07.2011)
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Conference Proceeding
Journal Article
A VH4-34+ myeloma protein with weak autoreactivity
Froyland, Marianne, Thompson, Keith M, Thorpe, Susan J, Sahota, Surinder S, Gedde-Dahl, Tobias, Bogen, Bjarne
Published in Haematologica (Roma) (01.05.2007)
Published in Haematologica (Roma) (01.05.2007)
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Journal Article
An autologous endothelial cell:peripheral blood mononuclear cell assay that detects cytokine storm responses to biologics
Reed, Daniel M, Paschalaki, Koralia E, Starke, Richard D, Mohamed, Nura A, Sharp, Giles, Fox, Bernard, Eastwood, David, Bristow, Adrian, Ball, Christina, Vessillier, Sandrine, Hansel, Trevor T, Thorpe, Susan J, Randi, Anna M, Stebbings, Richard, Mitchell, Jane A
Published in The FASEB journal (01.06.2015)
Published in The FASEB journal (01.06.2015)
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Journal Article
Comparison of novel methods for predicting the risk of pro-inflammatory clinical infusion reactions during monoclonal antibody therapy
Findlay, Lucy, Eastwood, David, Ball, Christina, Robinson, C. Jane, Bird, Chris, Wadhwa, Meenu, Thorpe, Susan J., Thorpe, Robin, Stebbings, Richard, Poole, Stephen
Published in Journal of immunological methods (31.08.2011)
Published in Journal of immunological methods (31.08.2011)
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Journal Article
Antibody C region influences TGN1412-like functional activity in vitro
Ball, Christina, Fox, Bernard, Hufton, Simon, Sharp, Giles, Poole, Stephen, Stebbings, Richard, Eastwood, David, Findlay, Lucy, Parren, Paul W H I, Thorpe, Robin, Bristow, Adrian, Thorpe, Susan J
Published in The Journal of immunology (1950) (15.12.2012)
Published in The Journal of immunology (1950) (15.12.2012)
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Journal Article
Consistent manufacturing and quality control of a highly complex recombinant polyclonal antibody product for human therapeutic use
Frandsen, Torben P., Næsted, Henrik, Rasmussen, Søren K., Hauptig, Peter, Wiberg, Finn C., Rasmussen, Lone Kjær, Jensen, Anne Marie Valentin, Persson, Pia, Wikén, Margareta, Engström, Anders, Jiang, Yun, Thorpe, Susan J., Förberg, Cecilia, Tolstrup, Anne B.
Published in Biotechnology and bioengineering (01.09.2011)
Published in Biotechnology and bioengineering (01.09.2011)
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Journal Article
Automated immunoassay methods for ferritin: recovery studies to assess traceability to an international standard
Blackmore, Sheena, Hamilton, Malcolm, Lee, Anne, Worwood, Mark, Brierley, Matthew, Heath, Alan, Thorpe, Susan J.
Published in Clinical chemistry and laboratory medicine (01.10.2008)
Published in Clinical chemistry and laboratory medicine (01.10.2008)
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Journal Article
Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture
Findlay, Lucy, Sharp, Giles, Fox, Bernard, Ball, Christina, Robinson, C. Jane, Bird, Christopher, Stebbings, Richard, Eastwood, David, Wadhwa, Meenu, Poole, Stephen, Thorpe, Robin, Thorpe, Susan J.
Published in Cytokine (Philadelphia, Pa.) (01.07.2011)
Published in Cytokine (Philadelphia, Pa.) (01.07.2011)
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Journal Article
International standard for serum vitamin B12 and serum folate : international collaborative study to evaluate a batch of lyophilised serum for B12 and folate content
THORPE, Susan J, HEATH, Alan, BLACKMORE, Sheena, LEE, Anne, HAMILTON, Malcolm, O'BROIN, Sean, NELSON, Bryant C, PFEIFFER, Christine
Published in Clinical chemistry and laboratory medicine (01.03.2007)
Published in Clinical chemistry and laboratory medicine (01.03.2007)
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Journal Article