A proof-of-concept study for the design of a VLP-based combinatorial HPV and placental malaria vaccine
Janitzek, Christoph M, Peabody, Julianne, Thrane, Susan, H R Carlsen, Philip, G Theander, Thor, Salanti, Ali, Chackerian, Bryce, A Nielsen, Morten, Sander, Adam F
Published in Scientific reports (27.03.2019)
Published in Scientific reports (27.03.2019)
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Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood Malaria
Lau, Clinton K.Y., Turner, Louise, Jespersen, Jakob S., Lowe, Edward D., Petersen, Bent, Wang, Christian W., Petersen, Jens E.V., Lusingu, John, Theander, Thor G., Lavstsen, Thomas, Higgins, Matthew K.
Published in Cell host & microbe (14.01.2015)
Published in Cell host & microbe (14.01.2015)
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Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity
Fougeroux, Cyrielle, Goksøyr, Louise, Idorn, Manja, Soroka, Vladislav, Myeni, Sebenzile K, Dagil, Robert, Janitzek, Christoph M, Søgaard, Max, Aves, Kara-Lee, Horsted, Emma W, Erdoğan, Sayit Mahmut, Gustavsson, Tobias, Dorosz, Jerzy, Clemmensen, Stine, Fredsgaard, Laurits, Thrane, Susan, Vidal-Calvo, Elena E, Khalifé, Paul, Hulen, Thomas M, Choudhary, Swati, Theisen, Michael, Singh, Susheel K, Garcia-Senosiain, Asier, Van Oosten, Linda, Pijlman, Gorben, Hierzberger, Bettina, Domeyer, Tanja, Nalewajek, Blanka W, Strøbæk, Anette, Skrzypczak, Magdalena, Andersson, Laura F, Buus, Søren, Buus, Anette Stryhn, Christensen, Jan Pravsgaard, Dalebout, Tim J, Iversen, Kasper, Harritshøj, Lene H, Mordmüller, Benjamin, Ullum, Henrik, Reinert, Line S, de Jongh, Willem Adriaan, Kikkert, Marjolein, Paludan, Søren R, Theander, Thor G, Nielsen, Morten A, Salanti, Ali, Sander, Adam F
Published in Nature communications (12.01.2021)
Published in Nature communications (12.01.2021)
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First-in-human, Randomized, Double-blind Clinical Trial of Differentially Adjuvanted PAMVAC, A Vaccine Candidate to Prevent Pregnancy-associated Malaria
Mordmüller, Benjamin, Sulyok, Mihály, Egger-Adam, Diane, Resende, Mafalda, de Jongh, Willem A, Jensen, Mette H, Smedegaard, Helle Holm, Ditlev, Sisse B, Soegaard, Max, Poulsen, Lars, Dyring, Charlotte, Calle, Carlos Lamsfus, Knoblich, Annette, Ibáñez, Javier, Esen, Meral, Deloron, Philippe, Ndam, Nicaise, Issifou, Saadou, Houard, Sophie, Howard, Randall F, Reed, Steven G, Leroy, Odile, Luty, Adrian J F, Theander, Thor G, Kremsner, Peter G, Salanti, Ali, Nielsen, Morten A
Published in Clinical infectious diseases (15.10.2019)
Published in Clinical infectious diseases (15.10.2019)
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Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, Sandeep K, Spliid, Charlotte B, Wang, Yong, Gustavsson, Tobias, Sandoval, Daniel R, Vidal-Calvo, Elena Ethel, Choudhary, Swati, Agerbaek, Mette Ø, Lindorff-Larsen, Kresten, Nielsen, Morten A, Theander, Thor G, Sharp, Joshua S, Clausen, Thomas Mandel, Gourdon, Pontus, Salanti, Ali
Published in Nature communications (19.05.2021)
Published in Nature communications (19.05.2021)
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The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
Agerbæk, Mette Ø, Bang-Christensen, Sara R, Yang, Ming-Hsin, Clausen, Thomas M, Pereira, Marina A, Sharma, Shreya, Ditlev, Sisse B, Nielsen, Morten A, Choudhary, Swati, Gustavsson, Tobias, Sorensen, Poul H, Meyer, Tim, Propper, David, Shamash, Jonathan, Theander, Thor G, Aicher, Alexandra, Daugaard, Mads, Heeschen, Christopher, Salanti, Ali
Published in Nature communications (16.08.2018)
Published in Nature communications (16.08.2018)
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Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1
Ayres Pereira, Marina, Mandel Clausen, Thomas, Pehrson, Caroline, Mao, Yang, Resende, Mafalda, Daugaard, Mads, Riis Kristensen, Anders, Spliid, Charlotte, Mathiesen, Line, E Knudsen, Lisbeth, Damm, Peter, G Theander, Thor, R Hansson, Stefan, A Nielsen, Morten, Salanti, Ali
Published in PLoS pathogens (01.08.2016)
Published in PLoS pathogens (01.08.2016)
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Mosaic and cocktail capsid-virus-like particle vaccines for induction of antibodies against the EPCR-binding CIDRα1 domain of PfEMP1
Riedmiller, Ilary, Fougeroux, Cyrielle, Jensen, Rasmus W, Kana, Ikhlaq H, Sander, Adam F, Theander, Thor G, Lavstsen, Thomas, Turner, Louise
Published in PloS one (24.07.2024)
Published in PloS one (24.07.2024)
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Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein
Salanti, Ali, Clausen, Thomas M., Agerbæk, Mette Ø., Al Nakouzi, Nader, Dahlbäck, Madeleine, Oo, Htoo Z., Lee, Sherry, Gustavsson, Tobias, Rich, Jamie R., Hedberg, Bradley J., Mao, Yang, Barington, Line, Pereira, Marina A., LoBello, Janine, Endo, Makoto, Fazli, Ladan, Soden, Jo, Wang, Chris K., Sander, Adam F., Dagil, Robert, Thrane, Susan, Holst, Peter J., Meng, Le, Favero, Francesco, Weiss, Glen J., Nielsen, Morten A., Freeth, Jim, Nielsen, Torsten O., Zaia, Joseph, Tran, Nhan L., Trent, Jeff, Babcook, John S., Theander, Thor G., Sorensen, Poul H., Daugaard, Mads
Published in Cancer cell (12.10.2015)
Published in Cancer cell (12.10.2015)
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PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum
Jiang, Lubin, Mu, Jianbing, Zhang, Qingfeng, Ni, Ting, Srinivasan, Prakash, Rayavara, Kempaiah, Yang, Wenjing, Turner, Louise, Lavstsen, Thomas, Theander, Thor G, Peng, Weiqun, Wei, Guiying, Jing, Qingqing, Wakabayashi, Yoshiyuki, Bansal, Abhisheka, Luo, Yan, Ribeiro, José M C, Scherf, Artur, Aravind, L, Zhu, Jun, Zhao, Keji, Miller, Louis H
Published in Nature (London) (11.07.2013)
Published in Nature (London) (11.07.2013)
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Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children
Lavstsen, Thomas, Turner, Louise, Saguti, Fredy, Magistrado, Pamela, Rask, Thomas S, Jespersen, Jakob S, Wang, Christian W, Berger, Sanne S, Baraka, Vito, Marquard, Andrea M, Seguin-Orlando, Andaine, Willerslev, Eske, Gilbert, M. Thomas P, Lusingu, John, Theander, Thor G
Published in Proceedings of the National Academy of Sciences - PNAS (26.06.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (26.06.2012)
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Severe malaria is associated with parasite binding to endothelial protein C receptor
Turner, Louise, Lavstsen, Thomas, Berger, Sanne S, Wang, Christian W, Petersen, Jens E V, Avril, Marion, Brazier, Andrew J, Freeth, Jim, Jespersen, Jakob S, Nielsen, Morten A, Magistrado, Pamela, Lusingu, John, Smith, Joseph D, Higgins, Matthew K, Theander, Thor G
Published in Nature (London) (27.06.2013)
Published in Nature (London) (27.06.2013)
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Improving the malaria transmission-blocking activity of a Plasmodium falciparum 48/45 based vaccine antigen by SpyTag/SpyCatcher mediated virus-like display
Singh, Susheel K, Thrane, Susan, Janitzek, Christoph M, Nielsen, Morten A, Theander, Thor G, Theisen, Michael, Salanti, Ali, Sander, Adam F
Published in Vaccine (27.06.2017)
Published in Vaccine (27.06.2017)
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A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants
Agnandji, Selidji Todagbe, Fernandes, José Francisco, Abossolo, Béatrice Peggy, Methogo, Barbara Gaelle Nfono Ondo, Adegnika, Ayola Akim, Issifou, Saadou, Sacarlal, Jahit, Aide, Pedro, Lanaspa, Miguel, Aponte, John J, Machevo, Sonia, Acacio, Sozinho, Bulo, Helder, Sigauque, Betuel, Alonso, Pedro, Abdulla, Salim, Salim, Nahya, Minja, Rose, Ahmed, Saumu, Ali, Ali Mohammed, Mtoro, Ali Takadir, Hamad, Ali Said, Tinto, Halidou, D'Alessandro, Umberto, Sorgho, Hermann, Valea, Innocent, Guiraud, Issa, Kaboré, Berenger, Sombié, Olivier, Guiguemdé, Robert Tinga, Ouédraogo, Jean Bosco, Otieno, Kephas, Awino, Norbert, McMorrow, Meredith, Laserson, Kayla F, Otieno, Walter, Otieno, Lucas, Otsyula, Nekoye, Gondi, Stacey, Otieno, Allan, Owira, Victorine, Oguk, Esther, Odongo, George, Ogutu, Bernhards, Njuguna, Patricia, Chilengi, Roma, Akoo, Pauline, Kerubo, Christine, Maingi, Charity, Lang, Trudie, Olotu, Ally, Marsh, Kevin, Mwambingu, Gabriel, Owusu-Agyei, Seth, Asante, Kwaku Poku, Osei-Kwakye, Kingsley, Dosoo, David, Asante, Isaac, Chandramohan, Daniel, Greenwood, Brian, Lusingu, John, Gesase, Samwel, Mahende, Coline, Liheluka, Edwin, Malle, Lincoln, Lemnge, Martha, Theander, Thor G, Drakeley, Chris, Ansong, Daniel, Agbenyega, Tsiri, Adjei, Samuel, Boateng, Harry Owusu, Rettig, Theresa, Bawa, John, Sarfo, Anima, Agyekum, Alex, Martinson, Francis, Hoffman, Irving, Mvalo, Tisungane, Kamthunzi, Portia, Nkomo, Rutendo, Tembo, Tapiwa, Tegha, Gerald, Kilembe, Jane, Chawinga, Chimwemwe, Ballou, W Ripley, Guerra, Yolanda, Jongert, Erik, Lapierre, Didier, Leach, Amanda, Ofori-Anyinam, Opokua, Vekemans, Johan, Carter, Terrell, Kaslow, David, Leboulleux, Didier, Loucq, Christian, Radford, Afiya, Savarese, Barbara, Schellenberg, David, Vansadia, Preeti
Published in The New England journal of medicine (13.12.2012)
Published in The New England journal of medicine (13.12.2012)
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Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria
Lennartz, Frank, Adams, Yvonne, Bengtsson, Anja, Olsen, Rebecca W., Turner, Louise, Ndam, Nicaise T., Ecklu-Mensah, Gertrude, Moussiliou, Azizath, Ofori, Michael F., Gamain, Benoit, Lusingu, John P., Petersen, Jens E.V., Wang, Christian W., Nunes-Silva, Sofia, Jespersen, Jakob S., Lau, Clinton K.Y., Theander, Thor G., Lavstsen, Thomas, Hviid, Lars, Higgins, Matthew K., Jensen, Anja T.R.
Published in Cell host & microbe (08.03.2017)
Published in Cell host & microbe (08.03.2017)
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The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility
Spliid, Charlotte B., Toledo, Alejandro Gomez, Sanderson, Patience, Mao, Yang, Gatto, Francesco, Gustavsson, Tobias, Choudhary, Swati, Saldanha, Ana L., Vogelsang, Rasmus P., Gögenur, Ismail, Theander, Thor G., Leach, Franklin E., Amster, I. Jonathan, Esko, Jeffrey D., Salanti, Ali, Clausen, Thomas Mandel
Published in The Journal of biological chemistry (01.12.2021)
Published in The Journal of biological chemistry (01.12.2021)
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Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice
Skeltved, Nanna, Nordmaj, Mie A, Berendtsen, Nicolai T, Dagil, Robert, Stormer, Emilie M R, Al-Nakouzi, Nader, Jiang, Ke, Aicher, Alexandra, Heeschen, Christopher, Gustavsson, Tobias, Choudhary, Swati, Gögenur, Ismail, Christensen, Jan P, Theander, Thor G, Daugaard, Mads, Salanti, Ali, Nielsen, Morten A
Published in Journal of experimental & clinical cancer research (28.04.2023)
Published in Journal of experimental & clinical cancer research (28.04.2023)
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A Novel Virus-Like Particle Based Vaccine Platform Displaying the Placental Malaria Antigen VAR2CSA
Thrane, Susan, Janitzek, Christoph M, Agerbæk, Mette Ø, Ditlev, Sisse B, Resende, Mafalda, Nielsen, Morten A, Theander, Thor G, Salanti, Ali, Sander, Adam F
Published in PloS one (23.11.2015)
Published in PloS one (23.11.2015)
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