Search Results - "Thomsen, William J." :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine2C Agonist: in Vitro and in Vivo Pharmacological Characterization

Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine2C Agonist: in Vitro and in Vivo Pharmacological Characterization

by Thomsen, William J, Grottick, Andrew J, Menzaghi, Frederique, Reyes-Saldana, Hazel, Espitia, Stephen, Yuskin, Diane, Whelan, Kevin, Martin, Michael, Morgan, Michael, Chen, Weichao, Al-Shamma, Hussien, Smith, Brian, Chalmers, Derek, Behan, Dominic
Published in The Journal of pharmacology and experimental therapeutics (01.05.2008)

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Nelotanserin, a Novel Selective Human 5-Hydroxytryptamine2A Inverse Agonist for the Treatment of Insomnia

Nelotanserin, a Novel Selective Human 5-Hydroxytryptamine2A Inverse Agonist for the Treatment of Insomnia

by Al-Shamma, Hussien A, Anderson, Christen, Chuang, Emil, Luthringer, Remy, Grottick, Andrew J, Hauser, Erin, Morgan, Michael, Shanahan, William, Teegarden, Bradley R, Thomsen, William J, Behan, Dominic
Published in The Journal of pharmacology and experimental therapeutics (01.01.2010)

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Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity

Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity

by SMITH, Brian M, SMITH, Jeffrey M, DIPANJAN SENGUPTA, THOMSEN, William J, SALDANA, Hazel R, WHELAN, Kevin T, MENZAGHI, Frederique, WEBB, Robert R, BEELEY, Nigel R. A, TSAI, James H, SCHULTZ, Jeffrey A, GILSON, Charles A, ESTRADA, Scott A, CHEN, Rita R, PARK, Douglas M, PRIETO, Emily B, GALLARDO, Charlemagne S
Published in Bioorganic & medicinal chemistry letters (01.03.2005)

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Parathyroid hormone (PTH) and PTH-related peptide domains contributing to activation of different PTH receptor-mediated signaling pathways

Parathyroid hormone (PTH) and PTH-related peptide domains contributing to activation of different PTH receptor-mediated signaling pathways

by Cupp, Meghan E, Nayak, Surendra K, Adem, Amina S, Thomsen, William J
Published in The Journal of pharmacology and experimental therapeutics (01.06.2013)

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Discovery and Structure−Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT2C Receptor Agonist for the Treatment of Obesity

Discovery and Structure−Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT2C Receptor Agonist for the Treatment of Obesity

by Smith, Brian M, Smith, Jeffrey M, Tsai, James H, Schultz, Jeffrey A, Gilson, Charles A, Estrada, Scott A, Chen, Rita R, Park, Douglas M, Prieto, Emily B, Gallardo, Charlemagne S, Sengupta, Dipanjan, Dosa, Peter I, Covel, Jon A, Ren, Albert, Webb, Robert R, Beeley, Nigel R. A, Martin, Michael, Morgan, Michael, Espitia, Stephen, Saldana, Hazel R, Bjenning, Christina, Whelan, Kevin T, Grottick, Andrew J, Menzaghi, Frederique, Thomsen, William J
Published in Journal of medicinal chemistry (24.01.2008)

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The potential use of selective 5-HT2C agonists in treating obesity

The potential use of selective 5-HT2C agonists in treating obesity

by Smith, Brian M, Thomsen, William J, Grottick, Andrew J
Published in Expert opinion on investigational drugs (01.03.2006)

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Rapid kinetics of .alpha.2-adrenergic inhibition of adenylate cyclase. Evidence for a distal rate-limiting step

Rapid kinetics of .alpha.2-adrenergic inhibition of adenylate cyclase. Evidence for a distal rate-limiting step

by Thomsen, William J, Neubig, Richard R
Published in Biochemistry (Easton) (01.10.1989)

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Discovery and SAR of new benzazepines as potent and selective 5-HT 2C receptor agonists for the treatment of obesity

Discovery and SAR of new benzazepines as potent and selective 5-HT 2C receptor agonists for the treatment of obesity

by Smith, Brian M., Smith, Jeffrey M., Tsai, James H., Schultz, Jeffrey A., Gilson, Charles A., Estrada, Scott A., Chen, Rita R., Park, Douglas M., Prieto, Emily B., Gallardo, Charlemagne S., Sengupta, Dipanjan, Thomsen, William J., Saldana, Hazel R., Whelan, Kevin T., Menzaghi, Frederique, Webb, Robert R., Beeley, Nigel R.A.
Published in Bioorganic & medicinal chemistry letters (01.03.2005)

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Journal Article

Nelotanserin, a Novel Selective Human 5-Hydroxytryptamine 2A Inverse Agonist for the Treatment of Insomnia

Nelotanserin, a Novel Selective Human 5-Hydroxytryptamine 2A Inverse Agonist for the Treatment of Insomnia

by Al-Shamma, Hussien A., Anderson, Christen, Chuang, Emil, Luthringer, Remy, Grottick, Andrew J., Hauser, Erin, Morgan, Michael, Shanahan, William, Teegarden, Bradley R., Thomsen, William J., Behan, Dominic
Published in The Journal of pharmacology and experimental therapeutics (01.01.2010)

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Journal Article

Mechanism of agonist and antagonist binding to .alpha.2 adrenergic receptors: evidence for a precoupled receptor-guanine nucleotide protein complex

Mechanism of agonist and antagonist binding to .alpha.2 adrenergic receptors: evidence for a precoupled receptor-guanine nucleotide protein complex

by Neubig, Richard R, Gantzos, Robin D, Thomsen, William J
Published in Biochemistry (Easton) (01.04.1988)

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Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine 2C Agonist: in Vitro and in Vivo Pharmacological Characterization

Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine 2C Agonist: in Vitro and in Vivo Pharmacological Characterization

by Thomsen, William J., Grottick, Andrew J., Menzaghi, Frederique, Reyes-Saldana, Hazel, Espitia, Stephen, Yuskin, Diane, Whelan, Kevin, Martin, Michael, Morgan, Michael, Chen, Weichao, Al-Shamma, Hussien, Smith, Brian, Chalmers, Derek, Behan, Dominic
Published in The Journal of pharmacology and experimental therapeutics (01.05.2008)

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Journal Article

Discovery and Structure-Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-l-methyl-1H-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT2C Receptor Agonist for the Treatment of Obesity

Discovery and Structure-Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-l-methyl-1H-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT2C Receptor Agonist for the Treatment of Obesity

by SMITH, Brian M, SMITH, Jeffrey M, SENGUPTA, Dipanjan, DOSA, Peter I, COVEL, Jon A, REN, Albert, WEBB, Robert R, BEELEY, Nigel R. A, MARTIN, Michael, MORGAN, Michael, ESPITIA, Stephen, SALDANA, Hazel R, TSAI, James H, BJENNING, Christina, WHELAN, Kevin T, GROTTICK, Andrew J, MENZAGHI, Frederique, THOMSEN, William J, SCHULTZ, Jeffrey A, GILSON, Charles A, ESTRADA, Scott A, CHEN, Rita R, PARK, Douglas M, PRIETO, Emily B, GALLARDO, Charlemagne S
Published in Journal of medicinal chemistry (2008)

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Journal Article

Discovery and Structure−Activity Relationship of (1 R )-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1 H -3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT 2C Receptor Agonist for the Treatment of Obesity

Discovery and Structure−Activity Relationship of (1 R )-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1 H -3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT 2C Receptor Agonist for the Treatment of Obesity

by Smith, Brian M., Smith, Jeffrey M., Tsai, James H., Schultz, Jeffrey A., Gilson, Charles A., Estrada, Scott A., Chen, Rita R., Park, Douglas M., Prieto, Emily B., Gallardo, Charlemagne S., Sengupta, Dipanjan, Dosa, Peter I., Covel, Jon A., Ren, Albert, Webb, Robert R., Beeley, Nigel R. A., Martin, Michael, Morgan, Michael, Espitia, Stephen, Saldana, Hazel R., Bjenning, Christina, Whelan, Kevin T., Grottick, Andrew J., Menzaghi, Frederique, Thomsen, William J.
Published in Journal of medicinal chemistry (01.01.2008)

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Journal Article

Discovery and SAR of new benzazepines as potent and selective 5-HT(2C) receptor agonists for the treatment of obesity

Discovery and SAR of new benzazepines as potent and selective 5-HT(2C) receptor agonists for the treatment of obesity

by Smith, Brian M, Smith, Jeffrey M, Tsai, James H, Schultz, Jeffrey A, Gilson, Charles A, Estrada, Scott A, Chen, Rita R, Park, Douglas M, Prieto, Emily B, Gallardo, Charlemagne S, Sengupta, Dipanjan, Thomsen, William J, Saldana, Hazel R, Whelan, Kevin T, Menzaghi, Frederique, Webb, Robert R, Beeley, Nigel R A
Published in Bioorganic & medicinal chemistry letters (01.03.2005)

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Journal Article

Localization of the Receptor Site for α -scorpion Toxins by Antibody Mapping: Implications for Sodium Channel Topology

Localization of the Receptor Site for α -scorpion Toxins by Antibody Mapping: Implications for Sodium Channel Topology

by Thomsen, William J., Catterall, William A.
Published in Proceedings of the National Academy of Sciences - PNAS (01.12.1989)

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Photoaffinity labeling of the brevetoxin receptor on sodium channels in rat brain synaptosomes

Photoaffinity labeling of the brevetoxin receptor on sodium channels in rat brain synaptosomes

by TRAINER, V. L, THOMSEN, W. J, CATTERALL, W. A, BADEN, D. G
Published in Molecular pharmacology (01.12.1991)

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Molecular approaches to receptors as targets for drug discovery

Molecular approaches to receptors as targets for drug discovery

by Herz, J M, Thomsen, W J, Yarbrough, G G
Published in Journal of receptors and signal transduction (01.01.1997)

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Rapid kinetics of α2-adrenergic inhibition of adenylate cyclase. Evidence for a distal rate-limiting step

Rapid kinetics of α2-adrenergic inhibition of adenylate cyclase. Evidence for a distal rate-limiting step

by THOMSEN, W. J, NEUBIG, R. R
Published in Biochemistry (Easton) (1989)

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Journal Article

How does a key fit a flexible lock? Structure and dynamics in receptor function

How does a key fit a flexible lock? Structure and dynamics in receptor function

by Neubig, R R, Thomsen, W J
Published in BioEssays (01.11.1989)

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Journal Article

Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof

Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof

by THOMSEN WILLIAM J, CHALMERS DEREK T, RUSSO JOSEPH F, BEHAN DOMINIC P, LIAW CHEN W
Year of Publication 13.07.2010

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