The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG
Kugler, Eitan, Madiwale, Shreyas, Yong, Darren, Thoms, Julie A. I., Birger, Yehudit, Sykes, David B., Schmoellerl, Johannes, Drakul, Aneta, Priebe, Valdemar, Yassin, Muhammad, Aqaqe, Nasma, Rein, Avigail, Fishman, Hila, Geron, Ifat, Chen, Chun-Wei, Raught, Brian, Liu, Qiao, Ogana, Heather, Liedke, Elisabeth, Bourquin, Jean-Pierre, Zuber, Johannes, Milyavsky, Michael, Pimanda, John, Privé, Gilbert G., Izraeli, Shai
Published in Nature communications (21.09.2023)
Published in Nature communications (21.09.2023)
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Journal Article
TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells
Truong, Peter, Shen, Sylvie, Joshi, Swapna, Islam, Md Imtiazul, Zhong, Ling, Raftery, Mark J., Afrasiabi, Ali, Alinejad-Rokny, Hamid, Nguyen, Mary, Zou, Xiaoheng, Bhuyan, Golam Sarower, Sarowar, Chowdhury H., Ghodousi, Elaheh S., Stonehouse, Olivia, Mohamed, Sara, Toscan, Cara E., Connerty, Patrick, Kakadia, Purvi M., Bohlander, Stefan K., Michie, Katharine A., Larsson, Jonas, Lock, Richard B., Walkley, Carl R., Thoms, Julie A. I., Jolly, Christopher J., Pimanda, John E.
Published in Nature communications (28.08.2024)
Published in Nature communications (28.08.2024)
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Journal Article
Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
Yang, Junyu, Gao, Chong, Liu, Miao, Liu, Yao-Chung, Kwon, Junsu, Qi, Jun, Tian, Xi, Stein, Alicia, Liu, Yanjing V, Kong, Nikki R, Wu, Yue, Yin, Shenyi, Xi, Jianzhong, Chen, Zhiyuan, Kumari, Kalpana, Wong, Hannan, Luo, Hongbo, Silberstein, Leslie E, Thoms, Julie A I, Unnikrishnan, Ashwin, Pimanda, John E, Tenen, Daniel G, Chai, Li
Published in Cancer research (Chicago, Ill.) (01.12.2021)
Published in Cancer research (Chicago, Ill.) (01.12.2021)
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Journal Article
Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells
Jing, Duohui, Bhadri, Vivek A., Beck, Dominik, Thoms, JulieA.I., Yakob, Nurul A., Wong, JasonW.H., Knezevic, Kathy, Pimanda, John E., Lock, Richard B.
Published in Blood (08.01.2015)
Published in Blood (08.01.2015)
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Journal Article
Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells
Thoms, Julie A.I., Truong, Peter, Subramanian, Shruthi, Knezevic, Kathy, Harvey, Gregory, Huang, Yizhou, Seneviratne, Janith A., Carter, Daniel R., Joshi, Swapna, Skhinas, Joanna, Chacon, Diego, Shah, Anushi, de Jong, Ineke, Beck, Dominik, Göttgens, Berthold, Larsson, Jonas, Wong, Jason W.H., Zanini, Fabio, Pimanda, John E.
Published in Blood (21.10.2021)
Published in Blood (21.10.2021)
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Journal Article
ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer
Thoms, Julie A.I., Birger, Yehudit, Foster, Sam, Knezevic, Kathy, Kirschenbaum, Yael, Chandrakanthan, Vashe, Jonquieres, Georg, Spensberger, Dominik, Wong, Jason W., Oram, S. Helen, Kinston, Sarah J., Groner, Yoram, Lock, Richard, MacKenzie, Karen L., Göttgens, Berthold, Izraeli, Shai, Pimanda, John E.
Published in Blood (30.06.2011)
Published in Blood (30.06.2011)
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Journal Article
Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes
Beck, Dominik, Thoms, Julie A.I., Perera, Dilmi, Schütte, Judith, Unnikrishnan, Ashwin, Knezevic, Kathy, Kinston, Sarah J., Wilson, Nicola K., O'Brien, Tracey A., Göttgens, Berthold, Wong, Jason W.H., Pimanda, John E.
Published in Blood (03.10.2013)
Published in Blood (03.10.2013)
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Journal Article
Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy
Liu, Yao-Chung, Kwon, Junsu, Fabiani, Emiliano, Xiao, Zhijian, Liu, Yanjing V., Follo, Matilde Y., Liu, Jinqin, Huang, Huijun, Gao, Chong, Liu, Jun, Falconi, Giulia, Valentini, Lia, Gurnari, Carmelo, Finelli, Carlo, Cocco, Lucio, Liu, Jin-Hwang, Jones, Adrianna I., Yang, Junyu, Yang, Henry, Thoms, Julie A.I., Unnikrishnan, Ashwin, Pimanda, John E., Pan, Rongqing, Bassal, Mahmoud A., Voso, Maria T., Tenen, Daniel G., Chai, Li
Published in The New England journal of medicine (26.05.2022)
Published in The New England journal of medicine (26.05.2022)
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Journal Article
A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network
Unnikrishnan, Ashwin, Guan, Yi F, Huang, Yizhou, Beck, Dominik, Thoms, Julie A I, Peirs, Sofie, Knezevic, Kathy, Ma, Shiyong, de Walle, Inge V, de Jong, Ineke, Ali, Zara, Zhong, Ling, Raftery, Mark J, Taghon, Tom, Larsson, Jonas, MacKenzie, Karen L, Van Vlierberghe, Pieter, Wong, Jason W H, Pimanda, John E
Published in Nucleic acids research (15.12.2016)
Published in Nucleic acids research (15.12.2016)
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Journal Article
OncoCis: annotation of cis-regulatory mutations in cancer
Perera, Dilmi, Chacon, Diego, Thoms, Julie A I, Poulos, Rebecca C, Shlien, Adam, Beck, Dominik, Campbell, Peter J, Pimanda, John E, Wong, Jason W H
Published in Genome biology (01.01.2014)
Published in Genome biology (01.01.2014)
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Journal Article
Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine
Yeola, Avani, Subramanian, Shruthi, Oliver, Rema A, Lucas, Christine A, Thoms, Julie A I, Yan, Feng, Olivier, Jake, Chacon, Diego, Tursky, Melinda L, Srivastava, Pallavi, Potas, Jason R, Hung, Tzongtyng, Power, Carl, Hardy, Philip, Ma, David D, Kilian, Kristopher A, McCarroll, Joshua, Kavallaris, Maria, Hesson, Luke B, Beck, Dominik, Curtis, David J, Wong, Jason W H, Hardeman, Edna C, Walsh, William R, Mobbs, Ralph, Chandrakanthan, Vashe, Pimanda, John E
Published in Science advances (01.01.2021)
Published in Science advances (01.01.2021)
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Journal Article
Transcriptional networks in acute myeloid leukemia
Thoms, Julie A. I., Beck, Dominik, Pimanda, John E.
Published in Genes chromosomes & cancer (01.12.2019)
Published in Genes chromosomes & cancer (01.12.2019)
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Journal Article
BloodChIP Xtra: an expanded database of comparative genome-wide transcription factor binding and gene-expression profiles in healthy human stem/progenitor subsets and leukemic cells
Thoms, Julie A I, Koch, Forrest C, Raei, Alireza, Subramanian, Shruthi, Wong, Jason W H, Vafaee, Fatemeh, Pimanda, John E
Published in Nucleic acids research (05.01.2024)
Published in Nucleic acids research (05.01.2024)
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Journal Article
The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1
Carmichael, Catherine L., Wang, Jueqiong, Nguyen, Thao, Kolawole, Oluseyi, Benyoucef, Aissa, De Mazière, Charlotte, Milne, Anna R., Samuel, Sona, Gillinder, Kevin, Hediyeh-zadeh, Soroor, Vo, Anh N.Q., Huang, Yizhou, Knezevic, Kathy, McInnes, William R.L., Shields, Benjamin J., Mitchell, Helen, Ritchie, Matthew E., Lammens, Tim, Lintermans, Beatrice, Van Vlierberghe, Pieter, Wong, Nicholas C., Haigh, Katharina, Thoms, Julie A.I., Toulmin, Emma, Curtis, David J., Oxley, Ethan P., Dickins, Ross A., Beck, Dominik, Perkins, Andrew, McCormack, Matthew P., Davis, Melissa J., Berx, Geert, Zuber, Johannes, Pimanda, John E., Kile, Benjamin T., Goossens, Steven, Haigh, Jody J.
Published in Blood (20.08.2020)
Published in Blood (20.08.2020)
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Journal Article
Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif
Poulos, Rebecca C., Thoms, Julie A.I., Guan, Yi Fang, Unnikrishnan, Ashwin, Pimanda, John E., Wong, Jason W.H.
Published in Cell reports (Cambridge) (13.12.2016)
Published in Cell reports (Cambridge) (13.12.2016)
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Journal Article
Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy
Schnegg-Kaufmann, Annatina S., Thoms, Julie A. I., Bhuyan, Golam Sarower, Hampton, Henry R., Vaughan, Lachlin, Rutherford, Kayleigh, Kakadia, Purvi M., Lee, Hui Mei, Johansson, Emma M. V., Failes, Timothy W., Arndt, Greg M., Koval, Jason, Lindeman, Robert, Warburton, Pauline, Rodriguez-Meira, Alba, Mead, Adam J., Unnikrishnan, Ashwin, Davidson, Sarah, Polizzotto, Mark N., Hertzberg, Mark, Papaemmanuil, Elli, Bohlander, Stefan K., Faridani, Omid R., Jolly, Christopher J., Zanini, Fabio, Pimanda, John E.
Published in Blood (16.03.2023)
Published in Blood (16.03.2023)
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Journal Article
Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method
Liu, Keqin, Beck, Dominik, Thoms, Julie A I, Liu, Liang, Zhao, Weiling, Pimanda, John E, Zhou, Xiaobo
Published in Bioinformatics (Oxford, England) (01.09.2017)
Published in Bioinformatics (Oxford, England) (01.09.2017)
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Journal Article
Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes
Unnikrishnan, Ashwin, Papaemmanuil, Elli, Beck, Dominik, Deshpande, Nandan P., Verma, Arjun, Kumari, Ashu, Woll, Petter S., Richards, Laura A., Knezevic, Kathy, Chandrakanthan, Vashe, Thoms, Julie A.I., Tursky, Melinda L., Huang, Yizhou, Ali, Zara, Olivier, Jake, Galbraith, Sally, Kulasekararaj, Austin G., Tobiasson, Magnus, Karimi, Mohsen, Pellagatti, Andrea, Wilson, Susan R., Lindeman, Robert, Young, Boris, Ramakrishna, Raj, Arthur, Christopher, Stark, Richard, Crispin, Philip, Curnow, Jennifer, Warburton, Pauline, Roncolato, Fernando, Boultwood, Jacqueline, Lynch, Kevin, Jacobsen, Sten Eirik W., Mufti, Ghulam J., Hellstrom-Lindberg, Eva, Wilkins, Marc R., MacKenzie, Karen L., Wong, Jason W.H., Campbell, Peter J., Pimanda, John E.
Published in Cell reports (Cambridge) (18.07.2017)
Published in Cell reports (Cambridge) (18.07.2017)
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Journal Article
Constitutive CHK1 Expression Drives a pSTAT3-CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth
Khanna, Anchit, Thoms, Julie A I, Stringer, Brett W, Chung, Sylvia A, Ensbey, Kathleen S, Jue, Toni Rose, Jahan, Zeenat, Subramanian, Shruthi, Anande, Govardhan, Shen, Han, Unnikrishnan, Ashwin, McDonald, Kerrie L, Day, Bryan W, Pimanda, John E
Published in Molecular cancer research (01.05.2020)
Published in Molecular cancer research (01.05.2020)
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