Gβγ-SNAP25 exocytotic brake removal enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity
Ceddia, Ryan P, Zurawski, Zack, Thompson Gray, Analisa, Adegboye, Feyisayo, McDonald-Boyer, Ainsley, Shi, Fubiao, Liu, Dianxin, Maldonado, Jose, Feng, Jiesi, Li, Yulong, Alford, Simon, Ayala, Julio E, McGuinness, Owen P, Collins, Sheila, Hamm, Heidi E
Published in The Journal of clinical investigation (02.10.2023)
Published in The Journal of clinical investigation (02.10.2023)
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Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes
Zurawski, Zack, Thompson Gray, Analisa D, Brady, Lillian J, Page, Brian, Church, Emily, Harris, Nicholas A, Dohn, Michael R, Yim, Yun Young, Hyde, Karren, Mortlock, Douglas P, Jones, Carrie K, Winder, Danny G, Alford, Simon, Hamm, Heidi E
Published in Science signaling (19.02.2019)
Published in Science signaling (19.02.2019)
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Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist
Iderberg, Hanna, Maslava, Natallia, Thompson, Analisa D., Bubser, Michael, Niswender, Colleen M., Hopkins, Corey R., Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K., Cenci, M. Angela
Published in Neuropharmacology (01.08.2015)
Published in Neuropharmacology (01.08.2015)
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Discovery, Structure–Activity Relationship, and Biological Characterization of a Novel Series of 6‑((1H‑Pyrazolo[4,3‑b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4)
Bollinger, Sean R, Engers, Darren W, Panarese, Joseph D, West, Mary, Engers, Julie L, Loch, Matthew T, Rodriguez, Alice L, Blobaum, Anna L, Jones, Carrie K, Thompson Gray, Analisa, Conn, P. Jeffrey, Lindsley, Craig W, Niswender, Colleen M, Hopkins, Corey R
Published in Journal of medicinal chemistry (10.01.2019)
Published in Journal of medicinal chemistry (10.01.2019)
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Sexual Dimorphism in Stress‐induced Hyperthermia in SNAP25Δ3 mice, a mouse model with disabled Gβγ regulation of the exocytotic fusion apparatus
Thompson Gray, Analisa D., Simonetti, Justice, Adegboye, Feyisayo, Jones, Carrie K., Zurawski, Zack, Hamm, Heidi E.
Published in The European journal of neuroscience (01.07.2020)
Published in The European journal of neuroscience (01.07.2020)
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Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats
Brady, Ashley E, Jones, Carrie K, Bridges, Thomas M, Kennedy, J Phillip, Thompson, Analisa D, Heiman, Justin U, Breininger, Micah L, Gentry, Patrick R, Yin, Huiyong, Jadhav, Satyawan B, Shirey, Jana K, Conn, P Jeffrey, Lindsley, Craig W
Published in The Journal of pharmacology and experimental therapeutics (01.12.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2008)
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Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease
Xiang, Zixiu, Thompson, Analisa D, Jones, Carrie K, Lindsley, Craig W, Conn, P Jeffrey
Published in The Journal of pharmacology and experimental therapeutics (01.03.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2012)
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Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents
Engers, Julie L, Rodriguez, Alice L, Konkol, Leah C, Morrison, Ryan D, Thompson, Analisa D, Byers, Frank W, Blobaum, Anna L, Chang, Sichen, Venable, Daryl F, Loch, Matthew T, Niswender, Colleen M, Daniels, J. Scott, Jones, Carrie K, Conn, P. Jeffrey, Lindsley, Craig W, Emmitte, Kyle A
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100
BYUN, Nellie E, GRANNAN, Michael, MELANCON, Bruce J, TARR, James C, BROGAN, John T, AVISON, Malcolm J, DEUTCH, Ariel Y, WESS, Jürgen, WOOD, Michael R, LINDSLEY, Craig W, GORE, John C, CONN, P. Jeffrey, BUBSER, Michael, JONES, Carrie K, BARRY, Robert L, THOMPSON, Analisa, ROSANELLI, John, GOWRISHANKAR, Raajaram, KELM, Nathaniel D, DAMON, Stephen, BRIDGESL, Thomas M
Published in Neuropsychopharmacology (New York, N.Y.) (01.06.2014)
Published in Neuropsychopharmacology (New York, N.Y.) (01.06.2014)
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Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4
Niswender, Colleen M, Johnson, Kari A, Weaver, C David, Jones, Carrie K, Xiang, Zixiu, Luo, Qingwei, Rodriguez, Alice L, Marlo, Joy E, de Paulis, Tomas, Thompson, Analisa D, Days, Emily L, Nalywajko, Tasha, Austin, Cheryl A, Williams, Michael Baxter, Ayala, Jennifer E, Williams, Richard, Lindsley, Craig W, Conn, P Jeffrey
Published in Molecular pharmacology (01.11.2008)
Published in Molecular pharmacology (01.11.2008)
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The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease
Jones, Carrie K, Bubser, Michael, Thompson, Analisa D, Dickerson, Jonathan W, Turle-Lorenzo, Nathalie, Amalric, Marianne, Blobaum, Anna L, Bridges, Thomas M, Morrison, Ryan D, Jadhav, Satyawan, Engers, Darren W, Italiano, Kimberly, Bode, Jacob, Daniels, J Scott, Lindsley, Craig W, Hopkins, Corey R, Conn, P Jeffrey, Niswender, Colleen M
Published in The Journal of pharmacology and experimental therapeutics (01.02.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2012)
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Discovery of (S)‑2-Cyclopentyl‑N‑((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro‑1H‑pyrrido[3,4‑b]indole-4-carboxamide (VU0453379): A Novel, CNS Penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) Positive Allosteric Modulator (PAM)
Morris, Lindsey C, Nance, Kellie D, Gentry, Patrick R, Days, Emily L, Weaver, C. David, Niswender, Colleen M, Thompson, Analisa D, Jones, Carrie K, Locuson, Chuck W, Morrison, Ryan D, Daniels, J. Scott, Niswender, Kevin D, Lindsley, Craig W
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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A Rodent Model of Traumatic Stress Induces Lasting Sleep and Quantitative Electroencephalographic Disturbances
Nedelcovych, Michael T, Gould, Robert W, Zhan, Xiaoyan, Bubser, Michael, Gong, Xuewen, Grannan, Michael, Thompson, Analisa T, Ivarsson, Magnus, Lindsley, Craig W, Conn, P. Jeffrey, Jones, Carrie K
Published in ACS chemical neuroscience (18.03.2015)
Published in ACS chemical neuroscience (18.03.2015)
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Discovery, Synthesis, and Structure–Activity Relationship Development of a Series of N-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an Antiparkinsonian Animal Model
Jones, Carrie K, Engers, Darren W, Thompson, Analisa D, Field, Julie R, Blobaum, Anna L, Lindsley, Stacey R, Zhou, Ya, Gogliotti, Rocco D, Jadhav, Satyawan, Zamorano, Rocio, Bogenpohl, Jim, Smith, Yoland, Morrison, Ryan, Daniels, J. Scott, Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W, Niswender, Colleen M, Hopkins, Corey R
Published in Journal of medicinal chemistry (10.11.2011)
Published in Journal of medicinal chemistry (10.11.2011)
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The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson’s Disease
Xiang, Zixiu, Thompson, Analisa D, Brogan, John T, Schulte, Michael L, Melancon, Bruce J, Mi, Debbie, Lewis, L. Michelle, Zou, Bende, Yang, Liya, Morrison, Ryan, Santomango, Tammy, Byers, Frank, Brewer, Katrina, Aldrich, Jonathan S, Yu, Haibo, Dawson, Eric S, Li, Min, McManus, Owen, Jones, Carrie K, Daniels, J. Scott, Hopkins, Corey R, Xie, Ximin Simon, Conn, P. Jeffrey, Weaver, C. David, Lindsley, Craig W
Published in ACS chemical neuroscience (21.12.2011)
Published in ACS chemical neuroscience (21.12.2011)
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Evaluation of the Indazole Analogs of 5‑MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists
Jayakodiarachchi, Navoda, Maurer, Mallory A., Schultz, Daniel C., Dodd, Cayden J., Thompson Gray, Analisa, Cho, Hyekyung P., Boutaud, Olivier, Jones, Carrie K., Lindsley, Craig W., Bender, Aaron M.
Published in ACS medicinal chemistry letters (08.02.2024)
Published in ACS medicinal chemistry letters (08.02.2024)
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Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy
Gogliotti, Rocco D., Engers, Darren W., Garcia-Barrantes, Pedro M., Panarese, Joseph D., Gentry, Patrick R., Blobaum, Anna L., Morrison, Ryan D., Daniels, J. Scott, Thompson, Analisa D., Jones, Carrie K., Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W., Hopkins, Corey R.
Published in Bioorganic & medicinal chemistry letters (15.06.2016)
Published in Bioorganic & medicinal chemistry letters (15.06.2016)
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Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers
Niswender, Colleen M, Jones, Carrie K, Lin, Xin, Bubser, Michael, Thompson Gray, Analisa, Blobaum, Anna L, Engers, Darren W, Rodriguez, Alice L, Loch, Matthew T, Daniels, J. Scott, Lindsley, Craig W, Hopkins, Corey R, Javitch, Jonathan A, Conn, P. Jeffrey
Published in ACS chemical neuroscience (21.09.2016)
Published in ACS chemical neuroscience (21.09.2016)
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Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5
Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Bollinger, Katrina A., Venable, Daryl F., Blobaum, Anna L., Byers, Frank W., Thompson Gray, Analisa, Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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