Search Results - "Thomas WOLTERING" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

by Haider, Ahmed, Gobbi, Luca, Kretz, Julian, Ullmer, Christoph, Brink, Andreas, Honer, Michael, Woltering, Thomas J, Muri, Dieter, Iding, Hans, Bürkler, Markus, Binder, Martin, Bartelmus, Christian, Knuesel, Irene, Pacher, Pal, Herde, Adrienne Müller, Spinelli, Francesco, Ahmed, Hazem, Atz, Kenneth, Keller, Claudia, Weber, Markus, Schibli, Roger, Mu, Linjing, Grether, Uwe, Ametamey, Simon M
Published in Journal of medicinal chemistry (24.09.2020)

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β‑Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

β‑Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

by Hilpert, Hans, Guba, Wolfgang, Woltering, Thomas J, Wostl, Wolfgang, Pinard, Emmanuel, Mauser, Harald, Mayweg, Alexander V, Rogers-Evans, Mark, Humm, Roland, Krummenacher, Daniela, Muser, Thorsten, Schnider, Christian, Jacobsen, Helmut, Ozmen, Laurence, Bergadano, Alessandra, Banner, David W, Hochstrasser, Remo, Kuglstatter, Andreas, David-Pierson, Pascale, Fischer, Holger, Polara, Alessandra, Narquizian, Robert
Published in Journal of medicinal chemistry (23.05.2013)

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BACE1 inhibitors: A head group scan on a series of amides

BACE1 inhibitors: A head group scan on a series of amides

by Woltering, Thomas J., Wostl, Wolfgang, Hilpert, Hans, Rogers-Evans, Mark, Pinard, Emmanuel, Mayweg, Alexander, Göbel, Martin, Banner, David W., Benz, Jörg, Travagli, Massimiliano, Pollastrini, Martina, Marconi, Guido, Gabellieri, Emanuele, Guba, Wolfgang, Mauser, Harald, Andreini, Matteo, Jacobsen, Helmut, Power, Eoin, Narquizian, Robert
Published in Bioorganic & medicinal chemistry letters (15.07.2013)

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An Intramolecular [2 + 2] Photocycloaddition Approach to Conformationally Restricted Bis-Pyrrolidines

An Intramolecular [2 + 2] Photocycloaddition Approach to Conformationally Restricted Bis-Pyrrolidines

by Fort, Diego A, Woltering, Thomas J, Alker, André M, Bach, Thorsten
Published in Journal of organic chemistry (01.08.2014)

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Synthesis of Fluorinated Tricyclic Scaffolds by Intramolecular [2+2] Photocycloaddition Reactions

Synthesis of Fluorinated Tricyclic Scaffolds by Intramolecular [2+2] Photocycloaddition Reactions

by Fort, Diego A., Woltering, Thomas J., Nettekoven, Matthias, Knust, Henner, Bach, Thorsten
Published in Angewandte Chemie (International ed.) (01.10.2012)

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Conformationally restricted pyrrolidines by intramolecular [2+2] photocycloaddition reactions

Conformationally restricted pyrrolidines by intramolecular [2+2] photocycloaddition reactions

by Fort, Diego A., Woltering, Thomas J., Nettekoven, Matthias, Knust, Henner, Bach, Thorsten
Published in Chemical communications (Cambridge, England) (14.04.2013)

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Synthesis and characterization of 1,3-dihydro-benzo[ b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists

Synthesis and characterization of 1,3-dihydro-benzo[ b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists

by Woltering, Thomas J., Wichmann, Jürgen, Goetschi, Erwin, Knoflach, Frédéric, Ballard, Theresa M., Huwyler, Jörg, Gatti, Silvia
Published in Bioorganic & medicinal chemistry letters (01.12.2010)

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PHOTOCHEMICAL REACTIONS OF PROP-2-ENYL AND PROP-2-YNYL SUBSTITUTED 4-AMINOMETHYL- AND 4-OXYMETHYL-2(5H)-FURANONES

PHOTOCHEMICAL REACTIONS OF PROP-2-ENYL AND PROP-2-YNYL SUBSTITUTED 4-AMINOMETHYL- AND 4-OXYMETHYL-2(5H)-FURANONES

by Fort, Diego A., Woltering, Thomas J., Alker, Andre M., Bach, Thorsten
Published in Heterocycles (01.01.2014)

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Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent

by Higgins, Guy A., Ballard, Theresa M., Kew, James N.C., Grayson Richards, J., Kemp, John A., Adam, Geo, Woltering, Thomas, Nakanishi, Shigetada, Mutel, Vincent
Published in Neuropharmacology (01.06.2004)

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Enantioselective functionalisation of the C-2' position of 1,2,3,4,5-pentamethylazaferrocene via sparteine mediated lithiation: potential new ligands for asymmetric catalysis

Enantioselective functionalisation of the C-2' position of 1,2,3,4,5-pentamethylazaferrocene via sparteine mediated lithiation: potential new ligands for asymmetric catalysis

by Anderson, James C., Osborne, James D., Woltering, Thomas J.
Published in Organic & biomolecular chemistry (21.01.2008)

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Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[ b][1,4]diazepin-2-one derivatives: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[ b][1,4]diazepin-2-one derivatives: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1

by Woltering, Thomas J., Adam, Geo, Alanine, Alexander, Wichmann, Jürgen, Knoflach, Frédéric, Mutel, Vincent, Gatti, Silvia
Published in Bioorganic & medicinal chemistry letters (15.12.2007)

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Effects of the mGluR2/3 agonist LY354740 on computerized tasks of attention and working memory in marmoset monkeys

Effects of the mGluR2/3 agonist LY354740 on computerized tasks of attention and working memory in marmoset monkeys

by Spinelli, Simona, Ballard, Theresa, Gatti-McArthur, Silvia, Richards, Grayson J, Kapps, Martin, Woltering, Thomas, Wichmann, Jurgen, Stadler, Heinz, Feldon, Joram, Pryce, Christopher R
Published in Psychopharmacology (01.04.2005)

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Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[ b][1,4]diazepin-2-one derivatives: Part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[ b][1,4]diazepin-2-one derivatives: Part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists

by Woltering, Thomas J., Adam, Geo, Wichmann, Jürgen, Goetschi, Erwin, Kew, James N.C., Knoflach, Frédéric, Mutel, Vincent, Gatti, Silvia
Published in Bioorganic & medicinal chemistry (01.02.2008)

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Mutagenesis and molecular modeling of the orthosteric binding site of the mGlu2 receptor determining interactions of the group II receptor antagonist (3)H-HYDIA

Mutagenesis and molecular modeling of the orthosteric binding site of the mGlu2 receptor determining interactions of the group II receptor antagonist (3)H-HYDIA

by Lundström, Linda, Kuhn, Bernd, Beck, Jennifer, Borroni, Edilio, Wettstein, Joseph G, Woltering, Thomas J, Gatti, Silvia
Published in ChemMedChem (01.07.2009)

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Synthesis and characterization of 1,3-dihydro-benzo[ b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists

Synthesis and characterization of 1,3-dihydro-benzo[ b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists

by Woltering, Thomas J., Wichmann, Jürgen, Goetschi, Erwin, Adam, Geo, Kew, James N.C., Knoflach, Frédéric, Ballard, Theresa M., Huwyler, Jörg, Mutel, Vincent, Gatti, Silvia
Published in Bioorganic & medicinal chemistry (15.04.2008)

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Asymmetric Synthesis and Receptor Pharmacology of the Group II mGlu Receptor Ligand (1S,2R,3R,5R,6S)-2-Amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid-HYDIA

Asymmetric Synthesis and Receptor Pharmacology of the Group II mGlu Receptor Ligand (1S,2R,3R,5R,6S)-2-Amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid-HYDIA

by Woltering, Thomas J., Adam, Geo, Huguenin, Philipp, Wichmann, Jürgen, Kolczewski, Sabine, Gatti, Silvia, Bourson, Anne, Kew, James N. C., Richards, Grayson, Kemp, John A., Mutel, Vincent, Knoflach, Frédéric
Published in ChemMedChem (15.02.2008)

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Mutagenesis and Molecular Modeling of the Orthosteric Binding Site of the mGlu2 Receptor Determining Interactions of the Group II Receptor Antagonist 3H-HYDIA

Mutagenesis and Molecular Modeling of the Orthosteric Binding Site of the mGlu2 Receptor Determining Interactions of the Group II Receptor Antagonist 3H-HYDIA

by Lundström, Linda, Kuhn, Bernd, Beck, Jennifer, Borroni, Edilio, Wettstein, Joseph G., Woltering, Thomas J., Gatti, Silvia
Published in ChemMedChem (06.07.2009)

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In Vitro Binding Characteristics of a New Selective Group II Metabotropic Glutamate Receptor Radioligand, [3H]LY354740, in Rat Brain

In Vitro Binding Characteristics of a New Selective Group II Metabotropic Glutamate Receptor Radioligand, [3H]LY354740, in Rat Brain

by Schaffhauser, H, Richards, J G, Cartmell, J, Chaboz, S, Kemp, J A, Klingelschmidt, A, Messer, J, Stadler, H, Woltering, T, Mutel, V
Published in Molecular pharmacology (01.02.1998)

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Enantioselective functionalisation of the C-2′ position of 1,2,3,4,5-pentamethylazaferroceneviasparteine mediated lithiation: potential new ligands for asymmetric catalysis

Enantioselective functionalisation of the C-2′ position of 1,2,3,4,5-pentamethylazaferroceneviasparteine mediated lithiation: potential new ligands for asymmetric catalysis

by Anderson, James C., Osborne, James D., Woltering, Thomas J.
Published in Organic & biomolecular chemistry (2008)

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Synthesis of Fluorinated Tricyclic Scaffolds by Intramolecular [2+2] Photocycloaddition Reactions

Synthesis of Fluorinated Tricyclic Scaffolds by Intramolecular [2+2] Photocycloaddition Reactions

by Fort, Diego A., Woltering, Thomas J., Nettekoven, Matthias, Knust, Henner, Bach, Thorsten
Published in Angewandte Chemie (01.10.2012)

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