High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism
Griffin, Jennifer E, Gawronski, Jeffrey D, Dejesus, Michael A, Ioerger, Thomas R, Akerley, Brian J, Sassetti, Christopher M
Published in PLoS pathogens (01.09.2011)
Published in PLoS pathogens (01.09.2011)
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TRANSIT--A Software Tool for Himar1 TnSeq Analysis
DeJesus, Michael A, Ambadipudi, Chaitra, Baker, Richard, Sassetti, Christopher, Ioerger, Thomas R
Published in PLoS computational biology (01.10.2015)
Published in PLoS computational biology (01.10.2015)
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Journal Article
Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing
Zhang, Yanjia J., Reddy, Manchi C., Ioerger, Thomas R., Rothchild, Alissa C., Dartois, Veronique, Schuster, Brian M., Trauner, Andrej, Wallis, Deeann, Galaviz, Stacy, Huttenhower, Curtis, Sacchettini, James C., Behar, Samuel M., Rubin, Eric J.
Published in Cell (05.12.2013)
Published in Cell (05.12.2013)
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Journal Article
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis
Ioerger, Thomas R, O'Malley, Theresa, Liao, Reiling, Guinn, Kristine M, Hickey, Mark J, Mohaideen, Nilofar, Murphy, Kenan C, Boshoff, Helena I M, Mizrahi, Valerie, Rubin, Eric J, Sassetti, Christopher M, Barry, 3rd, Clifton E, Sherman, David R, Parish, Tanya, Sacchettini, James C
Published in PloS one (23.09.2013)
Published in PloS one (23.09.2013)
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A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide
Yadon, Adam N, Maharaj, Kashmeel, Adamson, John H, Lai, Yi-Pin, Sacchettini, James C, Ioerger, Thomas R, Rubin, Eric J, Pym, Alexander S
Published in Nature communications (19.09.2017)
Published in Nature communications (19.09.2017)
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Journal Article
Comprehensive analysis of iron utilization by Mycobacterium tuberculosis
Zhang, Lei, Hendrickson, R Curtis, Meikle, Virginia, Lefkowitz, Elliot J, Ioerger, Thomas R, Niederweis, Michael
Published in PLoS pathogens (18.02.2020)
Published in PLoS pathogens (18.02.2020)
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Journal Article
TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities
Carey, Allison F, Rock, Jeremy M, Krieger, Inna V, Chase, Michael R, Fernandez-Suarez, Marta, Gagneux, Sebastien, Sacchettini, James C, Ioerger, Thomas R, Fortune, Sarah M
Published in PLoS pathogens (05.03.2018)
Published in PLoS pathogens (05.03.2018)
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Journal Article
Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape
Baranowski, Catherine, Welsh, Michael A, Sham, Lok-To, Eskandarian, Haig A, Lim, Hoong Chuin, Kieser, Karen J, Wagner, Jeffrey C, McKinney, John D, Fantner, Georg E, Ioerger, Thomas R, Walker, Suzanne, Bernhardt, Thomas G, Rubin, Eric J, Rego, E Hesper
Published in eLife (16.10.2018)
Published in eLife (16.10.2018)
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Journal Article
PPE51 mediates uptake of trehalose across the mycomembrane of Mycobacterium tuberculosis
Babu Sait, Mohammed Rizwan, Koliwer-Brandl, Hendrik, Stewart, Jessica A, Swarts, Benjamin M, Jacobsen, Marc, Ioerger, Thomas R, Kalscheuer, Rainer
Published in Scientific reports (08.02.2022)
Published in Scientific reports (08.02.2022)
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Journal Article
Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice
Smith, Clare M, Baker, Richard E, Proulx, Megan K, Mishra, Bibhuti B, Long, Jarukit E, Park, Sae Woong, Lee, Ha-Na, Kiritsy, Michael C, Bellerose, Michelle M, Olive, Andrew J, Murphy, Kenan C, Papavinasasundaram, Kadamba, Boehm, Frederick J, Reames, Charlotte J, Meade, Rachel K, Hampton, Brea K, Linnertz, Colton L, Shaw, Ginger D, Hock, Pablo, Bell, Timothy A, Ehrt, Sabine, Schnappinger, Dirk, Pardo-Manuel de Villena, Fernando, Ferris, Martin T, Ioerger, Thomas R, Sassetti, Christopher M
Published in eLife (03.02.2022)
Published in eLife (03.02.2022)
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Journal Article
Leaderless Transcripts and Small Proteins Are Common Features of the Mycobacterial Translational Landscape
Shell, Scarlet S, Wang, Jing, Lapierre, Pascal, Mir, Mushtaq, Chase, Michael R, Pyle, Margaret M, Gawande, Richa, Ahmad, Rushdy, Sarracino, David A, Ioerger, Thomas R, Fortune, Sarah M, Derbyshire, Keith M, Wade, Joseph T, Gray, Todd A
Published in PLoS genetics (01.11.2015)
Published in PLoS genetics (01.11.2015)
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Journal Article
Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection
FORD, Christopher B, PHILANA LING LIN, FLYNN, Joanne L, FORTUNE, Sarah M, CHASE, Michael R, SHAH, Rupal R, IARTCHOUK, Oleg, GALAGAN, James, MOHAIDEEN, Nilofar, IOERGER, Thomas R, SACCHETTINI, James C, LIPSITCH, Marc
Published in Nature genetics (01.05.2011)
Published in Nature genetics (01.05.2011)
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Transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding protein involved in septal peptidoglycan synthesis and antibiotic sensitivity
Akusobi, Chidiebere, Benghomari, Bouchra S, Zhu, Junhao, Wolf, Ian D, Singhvi, Shreya, Dulberger, Charles L, Ioerger, Thomas R, Rubin, Eric J
Published in eLife (06.06.2022)
Published in eLife (06.06.2022)
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Journal Article
MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212
LA ROSA, Valentina, POCE, Giovanna, JAVID, Babak, SORRENTINO, Flavia, LOERGER, Thomas R, SACCHETTINI, James C, MANETTI, Fabrizio, BOTTA, Maurizio, DE LOGU, Alessandro, RUBIN, Eric J, DE ROSSI, Edda, ORTIZ CANSECO, Julio, BURONI, Silvia, PASCA, Maria Rosalia, BIAVA, Mariangela, RAJU, Ravikiran M, PORRETTA, Giulio Cesare, ALFONSO, Salvatore, BATTILOCCHIO, Claudio
Published in Antimicrobial Agents and Chemotherapy (01.01.2012)
Published in Antimicrobial Agents and Chemotherapy (01.01.2012)
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A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis
Boutte, Cara C, Baer, Christina E, Papavinasasundaram, Kadamba, Liu, Weiru, Chase, Michael R, Meniche, Xavier, Fortune, Sarah M, Sassetti, Christopher M, Ioerger, Thomas R, Rubin, Eric J
Published in eLife (15.06.2016)
Published in eLife (15.06.2016)
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Journal Article
Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility
Kieser, Karen J, Baranowski, Catherine, Chao, Michael C, Long, Jarukit E, Sassetti, Christopher M, Waldor, Matthew K, Sacchettini, James C, Ioerger, Thomas R, Rubin, Eric J
Published in Proceedings of the National Academy of Sciences - PNAS (20.10.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (20.10.2015)
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Journal Article
Variation among Genome Sequences of H37Rv Strains of Mycobacterium tuberculosis from Multiple Laboratories
IOERGER, Thomas R, YICHENG FENG, SASSETTI, Chris, SACCHETTINI, James C, GANESULA, Krishna, XIAOHUA CHEN, DOBOS, Karen M, FORTUNE, Sarah, JACOBS, William R, MIZRAHI, Valerie, PARISH, Tanya, RUBIN, Eric
Published in Journal of Bacteriology (01.07.2010)
Published in Journal of Bacteriology (01.07.2010)
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