Actin-Myosin Interaction: Structure, Function and Drug Discovery
Guhathakurta, Piyali, Prochniewicz, Ewa, Thomas, David D
Published in International journal of molecular sciences (05.09.2018)
Published in International journal of molecular sciences (05.09.2018)
Get full text
Journal Article
Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity
Oda, Tetsuro, Yang, Yi, Uchinoumi, Hitoshi, Thomas, David D, Chen-Izu, Ye, Kato, Takayoshi, Yamamoto, Takeshi, Yano, Masafumi, Cornea, Razvan L, Bers, Donald M
Published in Journal of molecular and cellular cardiology (01.08.2015)
Published in Journal of molecular and cellular cardiology (01.08.2015)
Get full text
Journal Article
Kinetics and mapping of Ca-driven calmodulin conformations on skeletal and cardiac muscle ryanodine receptors
Rebbeck, Robyn T., Svensson, Bengt, Zhang, Jingyan, Samsó, Montserrat, Thomas, David D., Bers, Donald M., Cornea, Razvan L.
Published in Nature communications (15.06.2024)
Published in Nature communications (15.06.2024)
Get full text
Journal Article
Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states
Lake, Eric W., Muretta, Joseph M., Thompson, Andrew R., Rasmussen, Damien M., Majumdar, Abir, Faber, Erik B., Ruff, Emily F., Thomas, David D., Levinson, Nicholas M.
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2018)
Get full text
Journal Article
Assessing the Correlation Between Physical Activity and Quality of Life in Advanced Lung Cancer
Bade, Brett C., Brooks, Mary C., Nietert, Sloan B., Ulmer, Ansley, Thomas, D. David, Nietert, Paul J., Scott, JoAnn B., Silvestri, Gerard A.
Published in Integrative cancer therapies (01.03.2018)
Published in Integrative cancer therapies (01.03.2018)
Get full text
Journal Article
Site-directed spectroscopy of cardiac myosin-binding protein C reveals effects of phosphorylation on protein structural dynamics
Colson, Brett A., Thompson, Andrew R., Espinoza-Fonseca, L. Michel, Thomas, David D.
Published in Proceedings of the National Academy of Sciences - PNAS (22.03.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (22.03.2016)
Get full text
Journal Article
Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies
Lo, Chih Hung, Lim, Colin Kin-Wye, Ding, Zhipeng, Wickramasinghe, Sanjula P., Braun, Anthony R., Ashe, Karen H., Rhoades, Elizabeth, Thomas, David D., Sachs, Jonathan N.
Published in Alzheimer's & dementia (01.11.2019)
Published in Alzheimer's & dementia (01.11.2019)
Get full text
Journal Article
Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation
Avery, Adam W., Fealey, Michael E., Wang, Fengbin, Orlova, Albina, Thompson, Andrew R., Thomas, David D., Hays, Thomas S., Egelman, Edward H.
Published in Nature communications (07.11.2017)
Published in Nature communications (07.11.2017)
Get full text
Journal Article
RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays
Rebbeck, Robyn T., Singh, Daniel P., Janicek, Kevyn A., Bers, Donald M., Thomas, David D., Launikonis, Bradley S., Cornea, Razvan L.
Published in Scientific reports (04.02.2020)
Published in Scientific reports (04.02.2020)
Get full text
Journal Article
Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering
Vunnam, Nagamani, Young, Malaney C., Liao, Elly E., Lo, Chih Hung, Huber, Evan, Been, MaryJane, Thomas, David D., Sachs, Jonathan N.
Published in Cancer biology & therapy (31.12.2023)
Published in Cancer biology & therapy (31.12.2023)
Get full text
Journal Article
Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators
Roopnarine, Osha, Yuen, Samantha L., Thompson, Andrew R., Roelike, Lauren N., Rebbeck, Robyn T., Bidwell, Philip A., Aldrich, Courtney C., Cornea, Razvan L., Thomas, David D.
Published in Scientific reports (01.07.2023)
Published in Scientific reports (01.07.2023)
Get full text
Journal Article
Synergistic FRET assays for drug discovery targeting RyR2 channels
Rebbeck, RobynT, Ginsburg, Kenneth S., Ko, Christopher Y., Fasoli, Anna, Rusch, Katherine, Cai, George F., Dong, Xiaoqiong, Thomas, David D., Bers, Donald M., Cornea, Razvan L.
Published in Journal of molecular and cellular cardiology (01.07.2022)
Published in Journal of molecular and cellular cardiology (01.07.2022)
Get full text
Journal Article
Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State
Svensson, Bengt, Nitu, Florentin R, Rebbeck, Robyn T, McGurran, Lindsey M, Oda, Tetsuro, Thomas, David D, Bers, Donald M, Cornea, Razvan L
Published in International journal of molecular sciences (08.08.2023)
Published in International journal of molecular sciences (08.08.2023)
Get full text
Journal Article
A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure
Guhathakurta, Piyali, Prochniewicz, Ewa, Roopnarine, Osha, Rohde, John A., Thomas, David D.
Published in Biophysical journal (11.07.2017)
Published in Biophysical journal (11.07.2017)
Get full text
Journal Article