Search Results - "Thiffeault, Catherine J."

Defining EMS and ENU dose–response relationships using the Pig-a mutation assay in rats by Dobo, Krista L., Fiedler, Ronald D., Gunther, William C., Thiffeault, Catherine J., Cammerer, Zoryana, Coffing, Stephanie L., Shutsky, Thomas, Schuler, Maik

“…• EMS induced a sublinear dose-response in mutation frequency in the rat. • ENU induced a sublinear dose-response in mutation frequency in rat. • Dose…”

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Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea - comparison with other in vivo genotoxicity endpoints by Cammerer, Zoryana, Bhalli, Javed A., Cao, Xuefei, Coffing, Stephanie L., Dickinson, Donna, Dobo, Krista L., Dobrovolsky, Vasily N., Engel, Maria, Fiedler, Ronald D., Gunther, William C., Heflich, Robert H., Pearce, Mason G., Shaddock, Joseph G., Shutsky, Thomas, Thiffeault, Catherine J., Schuler, Maik

“…N‐Ethyl‐N‐nitrosourea (ENU) was evaluated as part of the Stage III trial for the rat Pig‐a gene mutation assay. Groups of six‐ to eight‐week‐old male Sprague…”

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Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate by Gunther, William C., Coffing, Stephanie L., Dickinson, Donna A., Engel, Maria E., Fiedler, Ronald D., O'Lone, Susan D., Sanok, Kelley E., Thiffeault, Catherine J., Shutsky, Thomas J., Schuler, Maik J., Dobo, Krista L.

“…Ethyl methanesulfonate (EMS) was evaluated as part of the validation effort for the rat Pig‐a mutation assay and compared with other well‐established in vivo…”

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International Pig-a gene mutation assay trial: Evaluation of transferability across 14 laboratories by Dertinger, Stephen D., Phonethepswath, Souk, Weller, Pamela, Nicolette, John, Murray, Joel, Sonders, Paul, Vohr, Hans-Werner, Shi, Jing, Krsmanovic, Ljubica, Gleason, Carol, Custer, Laura, Henwood, Andrew, Sweder, Kevin, Stankowski Jr, Leon F., Roberts, Daniel J., Giddings, Amanda, Kenny, Julia, Lynch, Anthony M., Defrain, Céline, Nesslany, Fabrice, van der Leede, Bas-jan M., Van Doninck, Terry, Schuermans, Ann, Tanaka, Kentaro, Hiwata, Yoshie, Tajima, Osamu, Wilde, Eleanor, Elhajouji, Azeddine, Gunther, William C., Thiffeault, Catherine J., Shutsky, Thomas J., Fiedler, Ronald D., Kimoto, Takafumi, Bhalli, Javed A., Heflich, Robert H., MacGregor, James T.

“…A collaborative international trial was conducted to evaluate the reproducibility and transferability of an in vivo mutation assay based on the enumeration of…”

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