Genetic Ablation of the c-Cbl Ubiquitin Ligase Domain Results in Increased Energy Expenditure and Improved Insulin Action
MOLERO, Juan C, TURNER, Nigel, THIEN, Christine B. F, LANGDON, Wallace Y, JAMES, David E, COONEY, Gregory J
Published in Diabetes (New York, N.Y.) (01.12.2006)
Published in Diabetes (New York, N.Y.) (01.12.2006)
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Journal Article
Loss of c-Cbl E3 ubiquitin ligase activity enhances the development of myeloid leukemia in FLT3-ITD mutant mice
Taylor, Samuel J, Thien, Christine B.F, Dagger, Samantha A, Duyvestyn, Johanna M, Grove, Carolyn S, Lee, Benjamin H, Gilliland, D. Gary, Langdon, Wallace Y
Published in Experimental hematology (01.03.2015)
Published in Experimental hematology (01.03.2015)
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Journal Article
Dasatinib targets B-lineage cells but does not provide an effective therapy for myeloproliferative disease in c-Cbl RING finger mutant mice
Duyvestyn, Johanna M, Taylor, Samuel J, Dagger, Samantha A, Orandle, Marlene, Morse, 3rd, Herbert C, Thien, Christine B F, Langdon, Wallace Y
Published in PloS one (01.04.2014)
Published in PloS one (01.04.2014)
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Journal Article
c-Cbl Promotes T Cell Receptor-induced Thymocyte Apoptosis by Activating the Phosphatidylinositol 3-Kinase/Akt Pathway
Thien, Christine B.F., Dagger, Samantha A., Steer, James H., Koentgen, Frank, Jansen, Elisa S., Scott, Clare L., Langdon, Wallace Y.
Published in The Journal of biological chemistry (02.04.2010)
Published in The Journal of biological chemistry (02.04.2010)
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Journal Article
Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice
Mamchak, Alusha A, Thien, Christine B.F, Dagger, Samantha A, Lyandres, Julia, Jiang, Shuwei, Langdon, Wallace Y, DeFranco, Anthony L
Published in European journal of immunology (01.02.2010)
Published in European journal of immunology (01.02.2010)
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Journal Article
Cbl: many adaptations to regulate protein tyrosine kinases
Thien, Christine B. F, Langdon, Wallace Y
Published in Nature reviews. Molecular cell biology (01.04.2001)
Published in Nature reviews. Molecular cell biology (01.04.2001)
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Journal Article
Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions
Paolino, Magdalena, Thien, Christine B F, Gruber, Thomas, Hinterleitner, Reinhard, Baier, Gottfried, Langdon, Wallace Y, Penninger, Josef M
Published in The Journal of immunology (1950) (15.02.2011)
Published in The Journal of immunology (1950) (15.02.2011)
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Journal Article
A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis–induced macrophage apoptosis
Kundu, Manikuntala, Pathak, Sushil Kumar, Kumawat, Kuldeep, Basu, Sanchita, Chatterjee, Gargi, Pathak, Shresh, Noguchi, Takuya, Takeda, Kohsuke, Ichijo, Hidenori, Thien, Christine B F, Langdon, Wallace Y, Basu, Joyoti
Published in Nature immunology (01.08.2009)
Published in Nature immunology (01.08.2009)
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Journal Article
Myeloid Leukemia Development in c-Cbl RING Finger Mutant Mice Is Dependent on FLT3 Signaling
Rathinam, Chozhavendan, Thien, Christine B.F., Flavell, Richard A., Langdon, Wallace Y.
Published in Cancer cell (19.10.2010)
Published in Cancer cell (19.10.2010)
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Journal Article
c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action
Molero, Juan C, Jensen, Thomas E, Withers, Phil C, Couzens, Michelle, Herzog, Herbert, Thien, Christine B F, Langdon, Wallace Y, Walder, Ken, Murphy, Maria A, Bowtell, David D L, James, David E, Cooney, Gregory J
Published in The Journal of clinical investigation (01.11.2004)
Published in The Journal of clinical investigation (01.11.2004)
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Journal Article
Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes
Hoyne, Gerard F, Flening, Eleanor, Yabas, Mehmet, Teh, Charis, Altin, John A, Randall, Katrina, Thien, Christine B F, Langdon, Wallace Y, Goodnow, Christopher C
Published in The Journal of immunology (1950) (15.02.2011)
Published in The Journal of immunology (1950) (15.02.2011)
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Journal Article
Negative regulation of PTK signalling by Cbl proteins
Thien, Christine B F, Langdon, Wallace Y
Published in Growth factors (Chur, Switzerland) (01.06.2005)
Published in Growth factors (Chur, Switzerland) (01.06.2005)
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Journal Article
Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice
Murphy, Maria A., Schnall, Ralf G., Venter, Deon J., Barnett, Louise, Bertoncello, Ivan, Thien, Christine B. F., Langdon, Wallace Y., Bowtell, David D. L.
Published in Molecular and Cellular Biology (01.08.1998)
Published in Molecular and Cellular Biology (01.08.1998)
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Journal Article
Unaltered Negative Selection and Regulatory T cell Development of Self-reactive thymocytes in TCR transgenic Fyn-deficient Mice
Mamchak, Alusha A., Thien, Christine B.F., Dagger, Samantha A., Lyandres, Julia, Jiang, Shuwei, Langdon, Wallace Y., DeFranco, Anthony L.
Published in European journal of immunology (01.02.2010)
Published in European journal of immunology (01.02.2010)
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Journal Article