Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
Evavold, Charles L., Hafner-Bratkovič, Iva, Devant, Pascal, D’Andrea, Jasmin M., Ngwa, Elsy M., Boršić, Elvira, Doench, John G., LaFleur, Martin W., Sharpe, Arlene H., Thiagarajah, Jay R., Kagan, Jonathan C.
Published in Cell (19.08.2021)
Published in Cell (19.08.2021)
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Journal Article
Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia
Thiagarajah, Jay R., Chang, Jeffrey, Goettel, Jeremy A., Verkman, Alan S., Lencer, Wayne I.
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2017)
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Journal Article
Gasdermin D pore-forming activity is redox-sensitive
Devant, Pascal, Boršić, Elvira, Ngwa, Elsy M., Xiao, Haopeng, Chouchani, Edward T., Thiagarajah, Jay R., Hafner-Bratkovič, Iva, Evavold, Charles L., Kagan, Jonathan C.
Published in Cell reports (Cambridge) (31.01.2023)
Published in Cell reports (Cambridge) (31.01.2023)
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Journal Article
Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection
Yang, Daping, Jacobson, Amanda, Meerschaert, Kimberly A., Sifakis, Joseph Joy, Wu, Meng, Chen, Xi, Yang, Tiandi, Zhou, Youlian, Anekal, Praju Vikas, Rucker, Rachel A., Sharma, Deepika, Sontheimer-Phelps, Alexandra, Wu, Glendon S., Deng, Liwen, Anderson, Michael D., Choi, Samantha, Neel, Dylan, Lee, Nicole, Kasper, Dennis L., Jabri, Bana, Huh, Jun R., Johansson, Malin, Thiagarajah, Jay R., Riesenfeld, Samantha J., Chiu, Isaac M.
Published in Cell (27.10.2022)
Published in Cell (27.10.2022)
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Journal Article
The epithelial-specific ER stress sensor ERN2/IRE1β enables host-microbiota crosstalk to affect colon goblet cell development
Grey, Michael J, De Luca, Heidi, Ward, Doyle V, Kreulen, Irini Am, Bugda Gwilt, Katlynn, Foley, Sage E, Thiagarajah, Jay R, McCormick, Beth A, Turner, Jerrold R, Lencer, Wayne I
Published in The Journal of clinical investigation (01.09.2022)
Published in The Journal of clinical investigation (01.09.2022)
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Journal Article
Pycro-Manager: open-source software for customized and reproducible microscope control
Pinkard, Henry, Stuurman, Nico, Ivanov, Ivan E., Anthony, Nicholas M., Ouyang, Wei, Li, Bin, Yang, Bin, Tsuchida, Mark A., Chhun, Bryant, Zhang, Grace, Mei, Ryan, Anderson, Michael, Shepherd, Douglas P., Hunt-Isaak, Ian, Dunn, Raymond L., Jahr, Wiebke, Kato, Saul, Royer, Loïc A., Thiagarajah, Jay R., Eliceiri, Kevin W., Lundberg, Emma, Mehta, Shalin B., Waller, Laura
Published in Nature methods (01.03.2021)
Published in Nature methods (01.03.2021)
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Journal Article
Patient-derived enteroids provide a platform for the development of therapeutic approaches in microvillus inclusion disease
Kalashyan, Meri, Raghunathan, Krishnan, Oller, Haley, Bayer, Marie-Theres, Jimenez, Lissette, Roland, Joseph T, Kolobova, Elena, Hagen, Susan J, Goldsmith, Jeffrey D, Shub, Mitchell D, Goldenring, James R, Kaji, Izumi, Thiagarajah, Jay R
Published in The Journal of clinical investigation (16.10.2023)
Published in The Journal of clinical investigation (16.10.2023)
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Journal Article
Membrane Lipids in Epithelial Polarity: Sorting out the PIPs
Bugda Gwilt, Katlynn, Thiagarajah, Jay R
Published in Frontiers in cell and developmental biology (31.05.2022)
Published in Frontiers in cell and developmental biology (31.05.2022)
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Journal Article
ViCE: An automated and quantitative program to assess intestinal tissue morphology
La, Jeffrey, Raghunathan, Krishnan, Silvester, Jocelyn A., Thiagarajah, Jay R.
Published in Journal of pathology informatics (01.12.2024)
Published in Journal of pathology informatics (01.12.2024)
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Journal Article
Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea
Duan, Tianying, Cil, Onur, Thiagarajah, Jay R, Verkman, Alan S
Published in JCI insight (21.02.2019)
Published in JCI insight (21.02.2019)
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Journal Article
A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization
Luong, Phi, Li, Qian, Chen, Pin-Fang, Wrighton, Paul J, Chang, Denis, Dwyer, Sean, Bayer, Marie-Theres, Snapper, Scott B, Hansen, Steen H, Thiagarajah, Jay R, Goessling, Wolfram, Lencer, Wayne I
Published in Molecular biology of the cell (19.03.2020)
Published in Molecular biology of the cell (19.03.2020)
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Journal Article
Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion
Ma, Tonghui, Thiagarajah, Jay R, Yang, Hong, Sonawane, Nitin D, Folli, Chiara, Galietta, Luis J V, Verkman, A S
Published in The Journal of clinical investigation (01.12.2002)
Published in The Journal of clinical investigation (01.12.2002)
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Journal Article
The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion
Frank, S R, Köllmann, C P, van Lidth de Jeude, J F, Thiagarajah, J R, Engelholm, L H, Frödin, M, Hansen, S H
Published in Oncogene (30.03.2017)
Published in Oncogene (30.03.2017)
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Journal Article
Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease
Thiagarajah, Jay R, Yildiz, Hasan, Carlson, Taylor, Thomas, Alyssa R, Steiger, Casey, Pieretti, Alberto, Zukerberg, Lawrence R, Carrier, Rebecca L, Goldstein, Allan M
Published in PloS one (19.06.2014)
Published in PloS one (19.06.2014)
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