The identification of clinical candidate SB-480848 : A potent inhibitor of lipoprotein-associated phospholipase A2
BLACKIE, Josie A, BLOOMER, Jackie C, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L, SMITH, Stephen A, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, BROWN, Murray J. B, CHENG, Hung-Yuan, HAMMOND, Beverley, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
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The discovery of SB-435495: A potent, orally active inhibitor of lipoprotein-associated phospholipase A2 for evaluation in man
BLACKIE, Josie A, BLOOMER, Jackie C, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L, SMITH, Stephen A, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, BROWN, Murray J. B, CHENG, Hung-Yuan, ELLIOTT, Richard L, HAMMOND, Beverley, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
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Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones
BOYD, Helen F, FELL, Stephen C. M, STANSFIELD, Ian G, STANWAY, Steven J, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
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N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2
BOYD, Helen F, FELL, Stephen C. M, PORTER, Rod A, RAWLINGS, D. Anthony, SMITH, Stephen A, STANSFIELD, Ian G, TEW, David G, THEOBALD, Colin J, WHITTAKER, Caroline M, FLYNN, Sean T, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L
Published in Bioorganic & medicinal chemistry letters (20.11.2000)
Published in Bioorganic & medicinal chemistry letters (20.11.2000)
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Reversible inhibitors of the gastric (H+/K+)-ATPase. 3. 3-Substituted-4-(phenylamino)quinolines
Ife, Robert J, Brown, Thomas H, Keeling, David J, Leach, Colin A, Meeson, Malcolm L, Parsons, Michael E, Reavill, David R, Theobald, Colin J, Wiggall, Kenneth J
Published in Journal of medicinal chemistry (01.09.1992)
Published in Journal of medicinal chemistry (01.09.1992)
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1-(Arylpiperazinylamidoalkyl)-pyrimidones : Orally active inhibitors of lipoprotein-associated phospholipase A2
BLOOMER, Jackie C, BOYD, Helen F, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
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The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2
BOYD, Helen F, HAMMOND, Beverley, STANSFIELD, Ian G, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, SMITH, Stephen A
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
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Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 5. Substituted 2,4-Diaminoquinazolines and Thienopyrimidines
Ife, Robert J, Brown, Thomas H, Blurton, Peter, Keeling, David J, Leach, Colin A, Meeson, Malcolm L, Parsons, Michael E, Theobald, Colin J
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 4. Identification of an Inhibitor with an Intermediate Duration of Action
Leach, Colin A, Brown, Thomas H, Ife, Robert J, Keeling, David J, Parsons, Michael E, Theobald, Colin J, Wiggall, Kenneth J
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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2-[[(4-Amino-2-pyridyl)methyl]sulfinyl]benzimidazole H+/K+-ATPase inhibitors. The relationship between pyridine basicity, stability, and activity
Ife, Robert J, Dyke, Catherine A, Keeling, David J, Meenan, Eugene, Meeson, Malcolm L, Parsons, Michael E, Price, Carolyn A, Theobald, Colin J, Underwood, Anthony H
Published in Journal of medicinal chemistry (01.08.1989)
Published in Journal of medicinal chemistry (01.08.1989)
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Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones
Boyd, Helen F, Fell, Stephen C M, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Macphee, Colin H, Milliner, Kevin J, Pinto, Ivan L, Rawlings, D Anthony, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Theobald, Colin J, Whittaker, Caroline M
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
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Journal Article
The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A 2
Blackie, Josie A., Bloomer, Jackie C., Brown, Murray J.B., Cheng, Hung-Yuan, Hammond, Beverley, Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Lewis, V.Ann, Macphee, Colin H., Milliner, Kevin J., Moores, Kitty E., Pinto, Ivan L., Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Taylor, Maxine A., Theobald, Colin J.
Published in Bioorganic & medicinal chemistry letters (2003)
Published in Bioorganic & medicinal chemistry letters (2003)
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Journal Article
Potent, orally active inhibitors of lipoprotein-associated phospholipase A 2: 1-(biphenylmethylamidoalkyl)-pyrimidones
Boyd, Helen F., Fell, Stephen C.M., Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Macphee, Colin H., Milliner, Kevin J., Pinto, Ivan L., Rawlings, D.Anthony, Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Theobald, Colin J., Whittaker, Caroline M.
Published in Bioorganic & medicinal chemistry letters (2002)
Published in Bioorganic & medicinal chemistry letters (2002)
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Journal Article
The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man
Blackie, Josie A, Bloomer, Jackie C, Brown, Murray J B, Cheng, Hung-Yuan, Elliott, Richard L, Hammond, Beverley, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Lewis, V Ann, Macphee, Colin H, Milliner, Kevin J, Moores, Kitty E, Pinto, Ivan L, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Taylor, Maxine A, Theobald, Colin J, Whittaker, Caroline M
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
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Published in Bioorganic & medicinal chemistry letters (16.09.2002)
Journal Article
The discovery of SB-435495
Blackie, Josie A., Bloomer, Jackie C., Brown, Murray J.B., Cheng, Hung-Yuan, Elliott, Richard L., Hammond, Beverley, Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Lewis, V.Ann, Macphee, Colin H., Milliner, Kevin J., Moores, Kitty E., Pinto, Ivan L., Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Taylor, Maxine A., Theobald, Colin J., Whittaker, Caroline M.
Published in Bioorganic & medicinal chemistry letters (01.09.2002)
Published in Bioorganic & medicinal chemistry letters (01.09.2002)
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