Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice
Hancock, Laura A, Hennessy, Corinne E, Solomon, George M, Dobrinskikh, Evgenia, Estrella, Alani, Hara, Naoko, Hill, David B, Kissner, William J, Markovetz, Matthew R, Grove Villalon, Diane E, Voss, Matthew E, Tearney, Guillermo J, Carroll, Kate S, Shi, Yunlong, Schwarz, Marvin I, Thelin, William R, Rowe, Steven M, Yang, Ivana V, Evans, Christopher M, Schwartz, David A
Published in Nature communications (18.12.2018)
Published in Nature communications (18.12.2018)
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Journal Article
The in vitro effect of nebulised hypertonic saline on human bronchial epithelium
Goralski, Jennifer L, Wu, Dan, Thelin, William R, Boucher, Richard C, Button, Brian
Published in The European respiratory journal (01.05.2018)
Published in The European respiratory journal (01.05.2018)
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Journal Article
Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis
Esther, Jr, Charles R, Muhlebach, Marianne S, Ehre, Camille, Hill, David B, Wolfgang, Matthew C, Kesimer, Mehmet, Ramsey, Kathryn A, Markovetz, Matthew R, Garbarine, Ian C, Forest, M Gregory, Seim, Ian, Zorn, Bryan, Morrison, Cameron B, Delion, Martial F, Thelin, William R, Villalon, Diane, Sabater, Juan R, Turkovic, Lidija, Ranganathan, Sarath, Stick, Stephen M, Boucher, Richard C
Published in Science translational medicine (03.04.2019)
Published in Science translational medicine (03.04.2019)
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Journal Article
Mechanosensitive ATP release maintains proper mucus hydration of airways
Button, Brian, Okada, Seiko F, Frederick, Charles Brandon, Thelin, William R, Boucher, Richard C
Published in Science signaling (11.06.2013)
Published in Science signaling (11.06.2013)
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Journal Article
An Improved Inhaled Mucolytic to Treat Airway Muco-obstructive Diseases
Ehre, Camille, Rushton, Zachary L, Wang, Boya, Hothem, Lauren N, Morrison, Cameron B, Fontana, Nicholas C, Markovetz, Matthew R, Delion, Martial F, Kato, Takafumi, Villalon, Diane, Thelin, William R, Esther, Jr, Charles R, Hill, David B, Grubb, Barbara R, Livraghi-Butrico, Alessandra, Donaldson, Scott H, Boucher, Richard C
Published in American journal of respiratory and critical care medicine (15.01.2019)
Published in American journal of respiratory and critical care medicine (15.01.2019)
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Journal Article
Recapitulation of native human expression patterns of key transport and drug metabolism genes in an in vitro human donor-derived intestinal epithelium
Bliton, Jarrett, McQueen, Bryan, Zwarycz, Bailey, Lai, Benjamin, Bunger, Maureen, Chen, Eugene, Thelin, William
Published in Drug metabolism and pharmacokinetics (01.04.2024)
Published in Drug metabolism and pharmacokinetics (01.04.2024)
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Journal Article
Improved predictivity of human drug oral bioavailability and first-pass metabolism utilizing human primary jejunum in a multi-organ intestinal-liver MPS system
Spreen, Ashley, Abbas, Yassen, Sze, Hailey, Boazak, Elizabeth, Thelin, William, Kostrzewski, Tomasz
Published in Drug metabolism and pharmacokinetics (01.04.2024)
Published in Drug metabolism and pharmacokinetics (01.04.2024)
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Journal Article
Expression profiles of aquaporins in rat conjunctiva, cornea, lacrimal gland and Meibomian gland
Yu, Dongfang, Thelin, William R., Randell, Scott H., Boucher, Richard C.
Published in Experimental eye research (01.10.2012)
Published in Experimental eye research (01.10.2012)
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Journal Article
Transient anchorage of cross-linked glycosyl-phosphatidylinositol-anchored proteins depends on cholesterol, Src family kinases, caveolin, and phosphoinositides
Chen, Yun, Thelin, William R, Yang, Bing, Milgram, Sharon L, Jacobson, Ken
Published in The Journal of cell biology (09.10.2006)
Published in The Journal of cell biology (09.10.2006)
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Journal Article
Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease
Hirsh, Andrew J, Zhang, Jim, Zamurs, Andra, Fleegle, Jacquelyn, Thelin, William R, Caldwell, Ray A, Sabater, Juan R, Abraham, William M, Donowitz, Mark, Cha, Boyoung, Johnson, Kevin B, St George, Judith A, Johnson, M Ross, Boucher, Richard C
Published in The Journal of pharmacology and experimental therapeutics (01.04.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2008)
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Journal Article
Disulfide disruption reverses mucus dysfunction in allergic airway disease
Morgan, Leslie E, Jaramillo, Ana M, Shenoy, Siddharth K, Raclawska, Dorota, Emezienna, Nkechinyere A, Richardson, Vanessa L, Hara, Naoko, Harder, Anna Q, NeeDell, James C, Hennessy, Corinne E, El-Batal, Hassan M, Magin, Chelsea M, Grove Villalon, Diane E, Duncan, Gregg, Hanes, Justin S, Suk, Jung Soo, Thornton, David J, Holguin, Fernando, Janssen, William J, Thelin, William R, Evans, Christopher M
Published in Nature communications (11.01.2021)
Published in Nature communications (11.01.2021)
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Journal Article
Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR
Thelin, William R, Chen, Yun, Gentzsch, Martina, Kreda, Silvia M, Sallee, Jennifer L, Scarlett, Cameron O, Borchers, Christoph H, Jacobson, Ken, Stutts, M Jackson, Milgram, Sharon L
Published in The Journal of clinical investigation (01.02.2007)
Published in The Journal of clinical investigation (01.02.2007)
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Journal Article
Beyond the brush border: NHERF4 blazes new NHERF turf
Thelin, William R., Hodson, Caleb A., Milgram, Sharon L.
Published in The Journal of physiology (15.08.2005)
Published in The Journal of physiology (15.08.2005)
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Journal Article
The Cystic Fibrosis Transmembrane Conductance Regulator Is Regulated by a Direct Interaction with the Protein Phosphatase 2A
Thelin, William R., Kesimer, Mehmet, Tarran, Robert, Kreda, Silvia M., Grubb, Barbara R., Sheehan, John K., Stutts, M. Jackson, Milgram, Sharon L.
Published in The Journal of biological chemistry (16.12.2005)
Published in The Journal of biological chemistry (16.12.2005)
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