Binding Site Characterization and Resistance to a Class of Non-nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase
Kukolj, George, McGibbon, Graham A., McKercher, Ginette, Marquis, Martin, Lefèbvre, Sylvain, Thauvette, Louise, Gauthier, Jean, Goulet, Sylvie, Poupart, Marc-André, Beaulieu, Pierre L.
Published in The Journal of biological chemistry (25.11.2005)
Published in The Journal of biological chemistry (25.11.2005)
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Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds
Beaulieu, Pierre L., Gillard, James, Bykowski, Darren, Brochu, Christian, Dansereau, Nathalie, Duceppe, Jean-Simon, Haché, Bruno, Jakalian, Araz, Lagacé, Lisette, LaPlante, Steven, McKercher, Ginette, Moreau, Elaine, Perreault, Stéphane, Stammers, Timothy, Thauvette, Louise, Warrington, Jeff, Kukolj, George
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
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Crystal Structure of the E2 Transactivation Domain of Human Papillomavirus Type 11 Bound to a Protein Interaction Inhibitor
Wang, Yong, Coulombe, René, Cameron, Dale R., Thauvette, Louise, Massariol, Marie-Josée, Amon, Lynn M., Fink, Dominique, Titolo, Steve, Welchner, Ewald, Yoakim, Christiane, Archambault, Jacques, White, Peter W.
Published in The Journal of biological chemistry (20.02.2004)
Published in The Journal of biological chemistry (20.02.2004)
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Inhibition of Human Papillomavirus DNA Replication by Small Molecule Antagonists of the E1-E2 Protein Interaction
White, Peter W., Titolo, Steve, Brault, Karine, Thauvette, Louise, Pelletier, Alex, Welchner, Ewald, Bourgon, Lise, Doyon, Louise, Ogilvie, William W., Yoakim, Christiane, Cordingley, Michael G., Archambault, Jacques
Published in The Journal of biological chemistry (18.07.2003)
Published in The Journal of biological chemistry (18.07.2003)
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Characterization of Recombinant HPV6 and 11 E1 Helicases
White, Peter W., Pelletier, Alex, Brault, Karine, Titolo, Steve, Welchner, Ewald, Thauvette, Louise, Fazekas, Monika, Cordingley, Michael G., Archambault, Jacques
Published in The Journal of biological chemistry (22.06.2001)
Published in The Journal of biological chemistry (22.06.2001)
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Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors
Stammers, Timothy A., Coulombe, René, Rancourt, Jean, Thavonekham, Bounkham, Fazal, Gulrez, Goulet, Sylvie, Jakalian, Araz, Wernic, Dominic, Tsantrizos, Youla, Poupart, Marc-André, Bös, Michael, McKercher, Ginette, Thauvette, Louise, Kukolj, George, Beaulieu, Pierre L.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Benzimidazole Thumb Pocket I finger-loop inhibitors of HCV NS5B polymerase: Improved drug-like properties through C-2 SAR in three sub-series
Beaulieu, Pierre L., Dansereau, Nathalie, Duan, Jianmin, Garneau, Michel, Gillard, James, McKercher, Ginette, LaPlante, Steven, Lagacée, Lisette, Thauvette, Louise, Kukolj, George
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
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Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate
McKercher, Ginette, Beaulieu, Pierre L., Lamarre, Daniel, LaPlante, Steven, Lefebvre, Sylvain, Pellerin, Charles, Thauvette, Louise, Kukolj, George
Published in Nucleic acids research (01.01.2004)
Published in Nucleic acids research (01.01.2004)
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N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies
Beaulieu, Pierre L., Jolicoeur, Eric, Gillard, James, Brochu, Christian, Coulombe, René, Dansereau, Nathalie, Duan, Jianmin, Garneau, Michel, Jakalian, Araz, Kühn, Peter, Lagacé, Lisette, LaPlante, Steven, McKercher, Ginette, Perrault, Stéphane, Poirier, Martin, Poupart, Marc-André, Stammers, Timothy, Thauvette, Louise, Thavonekham, Bounkham, Kukolj, George
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Characterization of recombinant HPV6 and 11 E1 helicases: effect of ATP on the interaction of E1 with E2 and mapping of a minimal helicase domain
White, P W, Pelletier, A, Brault, K, Titolo, S, Welchner, E, Thauvette, L, Fazekas, M, Cordingley, M G, Archambault, J
Published in The Journal of biological chemistry (22.06.2001)
Published in The Journal of biological chemistry (22.06.2001)
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An ATPase Assay Using Scintillation Proximity Beads for High-Throughput Screening or Kinetic Analysis
Jeffery, Jamie A., Sharom, Jeffrey R., Fazekas, Monika, Rudd, Penny, Welchner, Ewald, Thauvette, Louise, White, Peter W.
Published in Analytical biochemistry (01.05.2002)
Published in Analytical biochemistry (01.05.2002)
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Functional screen of Inflammatory Bowel Disease genes reveals key epithelial functions
Ntunzwenimana, Jessy Carol, Boucher, Gabrielle, Paquette, Jean, Gosselin, Hugues, Alikashani, Azadeh, Morin, Nicolas, Beauchamp, Claudine, Thauvette, Louise, Rivard, Marie-Eve, Dupuis, Frederique, Deschenes, Sonia, Foisy, Sylvain, Latour, Frederic, Lavallee, Genevieve, Daly, Mark, Ramnik Xavier, The Igenomed Consortium, Charron, Guy, Goyette, Philippe, Rioux, John David
Published in bioRxiv (15.10.2021)
Published in bioRxiv (15.10.2021)
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Paper
Inactivation mechanism of tetrameric .beta.-galactosidase by gamma-rays involves both fragmentation and temperature-dependent denaturation of protomers
Potier, Michel, Thauvette, Louise, Michaud, Lorraine, Giroux, Suzanne, Beauregard, Guy
Published in Biochemistry (Easton) (01.08.1991)
Published in Biochemistry (Easton) (01.08.1991)
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Radiation inactivation of estrogen receptor in intact human breast cancer cells (MCF-7) Lack of energy transfer to the estradiol binding domain
Toulas, Christine, Beauregard, Guy, Delassus, Felicité, Thauvette, Louise, Potier, Michel, Bayard, Francis, Faye, Jean-Charles
Published in FEBS letters (08.07.1991)
Published in FEBS letters (08.07.1991)
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