Drug delivery technologies for autoimmunity therapies
Thatte, Ajay S., Weaver, Jessica D., Pearson, Ryan, Mitchell, Michael J.
Published in Advanced drug delivery reviews (01.09.2024)
Published in Advanced drug delivery reviews (01.09.2024)
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Molecular Mechanisms of Membrane Curvature Sensing by a Disordered Protein
Zeno, Wade F, Thatte, Ajay S, Wang, Liping, Snead, Wilton T, Lafer, Eileen M, Stachowiak, Jeanne C
Published in Journal of the American Chemical Society (03.07.2019)
Published in Journal of the American Chemical Society (03.07.2019)
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Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy
Swingle, Kelsey L., Safford, Hannah C., Geisler, Hannah C., Hamilton, Alex G., Thatte, Ajay S., Billingsley, Margaret M., Joseph, Ryann A., Mrksich, Kaitlin, Padilla, Marshall S., Ghalsasi, Aditi A., Alameh, Mohamad-Gabriel, Weissman, Drew, Mitchell, Michael J.
Published in Journal of the American Chemical Society (01.03.2023)
Published in Journal of the American Chemical Society (01.03.2023)
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Journal Article
Emerging strategies for nanomedicine in autoimmunity
Thatte, Ajay S., Billingsley, Margaret M., Weissman, Drew, Melamed, Jilian R., Mitchell, Michael J.
Published in Advanced drug delivery reviews (01.04.2024)
Published in Advanced drug delivery reviews (01.04.2024)
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Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines
Shepherd, Sarah J, Han, Xuexiang, Mukalel, Alvin J, El-Mayta, Rakan, Thatte, Ajay S, Wu, Jingyu, Padilla, Marshall S, Alameh, Mohamad-Gabriel, Srikumar, Neha, Lee, Daeyeon, Weissman, Drew, Issadore, David, Mitchell, Michael J
Published in Proceedings of the National Academy of Sciences - PNAS (15.08.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (15.08.2023)
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Journal Article
Orthogonal Design of Experiments for Engineering of Lipid Nanoparticles for mRNA Delivery to the Placenta
Safford, Hannah C., Swingle, Kelsey L., Geisler, Hannah C., Hamilton, Alex G., Thatte, Ajay S., Ghalsasi, Aditi A., Billingsley, Margaret M., Alameh, Mohamad‐Gabriel, Weissman, Drew, Mitchell, Michael J.
Published in Small (Weinheim an der Bergstrasse, Germany) (01.10.2024)
Published in Small (Weinheim an der Bergstrasse, Germany) (01.10.2024)
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Journal Article
In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism
Billingsley, Margaret M., Gong, Ningqiang, Mukalel, Alvin J., Thatte, Ajay S., El‐Mayta, Rakan, Patel, Savan K., Metzloff, Ann E., Swingle, Kelsey L., Han, Xuexiang, Xue, Lulu, Hamilton, Alex G., Safford, Hannah C., Alameh, Mohamad‐Gabriel, Papp, Tyler E., Parhiz, Hamideh, Weissman, Drew, Mitchell, Michael J.
Published in Small (Weinheim an der Bergstrasse, Germany) (01.03.2024)
Published in Small (Weinheim an der Bergstrasse, Germany) (01.03.2024)
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Journal Article
Oxidized mRNA Lipid Nanoparticles for In Situ Chimeric Antigen Receptor Monocyte Engineering
Mukalel, Alvin J., Hamilton, Alex G., Billingsley, Margaret M., Li, Jacqueline, Thatte, Ajay S., Han, Xuexiang, Safford, Hannah C., Padilla, Marshall S., Papp, Tyler, Parhiz, Hamideh, Weissman, Drew, Mitchell, Michael J.
Published in Advanced functional materials (01.07.2024)
Published in Advanced functional materials (01.07.2024)
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Clathrin senses membrane curvature
Zeno, Wade F., Hochfelder, Jacob B., Thatte, Ajay S., Wang, Liping, Gadok, Avinash K., Hayden, Carl C., Lafer, Eileen M., Stachowiak, Jeanne C.
Published in Biophysical journal (02.03.2021)
Published in Biophysical journal (02.03.2021)
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Journal Article
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy
Metzloff, Ann E., Padilla, Marshall S., Gong, Ningqiang, Billingsley, Margaret M., Han, Xuexiang, Merolle, Maria, Mai, David, Figueroa‐Espada, Christian G., Thatte, Ajay S., Haley, Rebecca M., Mukalel, Alvin J., Hamilton, Alex G., Alameh, Mohamad‐Gabriel, Weissman, Drew, Sheppard, Neil C., June, Carl H., Mitchell, Michael J.
Published in Advanced materials (Weinheim) (01.06.2024)
Published in Advanced materials (Weinheim) (01.06.2024)
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Journal Article
mRNA Lipid Nanoparticles for Ex Vivo Engineering of Immunosuppressive T Cells for Autoimmunity Therapies
Thatte, Ajay S., Hamilton, Alex G., Nachod, Benjamin E., Mukalel, Alvin J., Billingsley, Margaret M., Palanki, Rohan, Swingle, Kelsey L., Mitchell, Michael J.
Published in Nano letters (22.11.2023)
Published in Nano letters (22.11.2023)
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Journal Article
High-Throughput In Vivo Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route
Hamilton, Alex G., Swingle, Kelsey L., Thatte, Ajay S., Mukalel, Alvin J., Safford, Hannah C., Billingsley, Margaret M., El-Mayta, Rakan D., Han, Xuexiang, Nachod, Benjamin E., Joseph, Ryann A., Metzloff, Ann E., Mitchell, Michael J.
Published in ACS nano (25.06.2024)
Published in ACS nano (25.06.2024)
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Journal Article
EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta
Geisler, Hannah C., Ghalsasi, Aditi A., Safford, Hannah C., Swingle, Kelsey L., Thatte, Ajay S., Mukalel, Alvin J., Gong, Ningqiang, Hamilton, Alex G., Han, Emily L., Nachod, Benjamin E., Padilla, Marshall S., Mitchell, Michael J.
Published in Journal of controlled release (01.07.2024)
Published in Journal of controlled release (01.07.2024)
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Journal Article
Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery
Patel, Savan K, Billingsley, Margaret M, Mukalel, Alvin J, Thatte, Ajay S, Hamilton, Alex G, Gong, Ningqiang, El-Mayta, Rakan, Safford, Hannah C, Merolle, Maria, Mitchell, Michael J
Published in Theranostics (2024)
Published in Theranostics (2024)
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Responsive biomaterials: optimizing control of cancer immunotherapy
Xue, Lulu, Thatte, Ajay S., Mai, David, Haley, Rebecca M., Gong, Ningqiang, Han, Xuexiang, Wang, Karin, Sheppard, Neil C., June, Carl H., Mitchell, Michael J.
Published in Nature reviews. Materials (01.02.2024)
Published in Nature reviews. Materials (01.02.2024)
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Journal Article
In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells
Palanki, Rohan, Riley, John S, Bose, Sourav K, Luks, Valerie, Dave, Apeksha, Kus, Nicole, White, Brandon M, Ricciardi, Adele S, Swingle, Kelsey L, Xue, Lulu, Sung, Derek, Thatte, Ajay S, Safford, Hannah C, Chaluvadi, Venkata S, Carpenter, Marco, Han, Emily L, Maganti, Rohin, Hamilton, Alex G, Mrksich, Kaitlin, Billingsley, Margaret B, Zoltick, Philip W, Alameh, Mohamad-Gabriel, Weissman, Drew, Mitchell, Michael J, Peranteau, William H
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2024)
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Journal Article
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy (Adv. Mater. 26/2024)
Metzloff, Ann E., Padilla, Marshall S., Gong, Ningqiang, Billingsley, Margaret M., Han, Xuexiang, Merolle, Maria, Mai, David, Figueroa‐Espada, Christian G., Thatte, Ajay S., Haley, Rebecca M., Mukalel, Alvin J., Hamilton, Alex G., Alameh, Mohamad‐Gabriel, Weissman, Drew, Sheppard, Neil C., June, Carl H., Mitchell, Michael J.
Published in Advanced materials (Weinheim) (01.06.2024)
Published in Advanced materials (Weinheim) (01.06.2024)
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Journal Article
Clathrin Senses Membrane Curvature
Zeno, Wade F., Hochfelder, Jacob B., Thatte, Ajay S., Wang, Liping, Gadok, Avinash K., Hayden, Carl, Lafer, Eileen M., Stachowiak, Jeanne C.
Published in Biophysical journal (12.02.2021)
Published in Biophysical journal (12.02.2021)
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Journal Article