Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome
Yuan, Xuan, Gavriilaki, Eleni, Thanassi, Jane A, Yang, Guangwei, Baines, Andrea C, Podos, Steven D, Huang, Yongqing, Huang, Mingjun, Brodsky, Robert A
Published in Haematologica (Roma) (01.03.2017)
Published in Haematologica (Roma) (01.03.2017)
Get full text
Journal Article
Baseline Clinical Characteristics and Complement Biomarkers of Patients with C3 Glomerulopathy Enrolled in Two Phase 2 Studies Investigating the Factor D Inhibitor Danicopan
Podos, Steven D., Trachtman, Howard, Appel, Gerald B., Bomback, Andrew S., Dixon, Bradley P., Wetzels, Jack F.M., Cook, H. Terence, Parikh, Samir V., Pickering, Matthew C., Tumlin, James, Langman, Craig B., Lightstone, Liz, Sperati, C. John, Daina, Erica, Bouman, Koenraad Peter, Rice, Kara, Thanassi, Jane A., Huang, Mingjun, Nester, Carla, Remuzzi, Giuseppe
Published in American journal of nephrology (01.01.2023)
Published in American journal of nephrology (01.01.2023)
Get full text
Journal Article
Mechanistic Assessment of DNA Ligase as an Antibacterial Target in Staphylococcus aureus
PODOS, Steven D, THANASSI, Jane A, PUCCI, Michael J
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
Get full text
Journal Article
Selenophene-Containing Inhibitors of Type IIA Bacterial Topoisomerases
Wiles, Jason A, Phadke, Avinash S, Bradbury, Barton J, Pucci, Michael J, Thanassi, Jane A, Deshpande, Milind
Published in Journal of medicinal chemistry (12.05.2011)
Published in Journal of medicinal chemistry (12.05.2011)
Get full text
Journal Article
Bactericidal Activity of ACH-702 against Nondividing and Biofilm Staphylococci
PODOS, Steven D, THANASSI, Jane A, LEGGIO, Melissa, PUCCI, Michael J
Published in Antimicrobial Agents and Chemotherapy (01.07.2012)
Published in Antimicrobial Agents and Chemotherapy (01.07.2012)
Get full text
Journal Article
In Vitro Antituberculosis Activities of ACH-702, a Novel Isothiazoloquinolone, against Quinolone-Susceptible and Quinolone-Resistant Isolates
PUCCI, Michael J, ACKERMAN, Maria, THANASSI, Jane A, SHOEN, Carolyn M, CYNAMON, Michael H
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
Get full text
Journal Article
Schiff bases of indoline-2,3-dione: potential novel inhibitors of Mycobacterium tuberculosis (Mtb) DNA gyrase
Aboul-Fadl, Tarek, Abdel-Aziz, Hatem A, Abdel-Hamid, Mohammed K, Elsaman, Tilal, Thanassi, Jane, Pucci, Michael J
Published in Molecules (Basel, Switzerland) (13.09.2011)
Published in Molecules (Basel, Switzerland) (13.09.2011)
Get full text
Journal Article
Identification of 113 conserved essential genes using a high‐throughput gene disruption system in Streptococcus pneumoniae
Thanassi, Jane A., Hartman‐Neumann, Sandra L., Dougherty, Thomas J., Dougherty, Brian A., Pucci, Michael J.
Published in Nucleic acids research (15.07.2002)
Published in Nucleic acids research (15.07.2002)
Get full text
Journal Article
Exploration of the Activity of 7-Pyrrolidino-8-methoxyisothiazoloquinolones against Methicillin-Resistant Staphylococcus aureus (MRSA)
Kim, Ha Young, Wiles, Jason A, Wang, Qiuping, Pais, Godwin C. G, Lucien, Edlaine, Hashimoto, Akihiro, Nelson, David M, Thanassi, Jane A, Podos, Steven D, Deshpande, Milind, Pucci, Michael J, Bradbury, Barton J
Published in Journal of medicinal chemistry (12.05.2011)
Published in Journal of medicinal chemistry (12.05.2011)
Get full text
Journal Article
Comparison of complement functional assays: Differential sensitivities of hemolysis and Wieslab assays to levels of complement proteins C5, factor B, and factor D
Thanassi, Jane A, Patel, Dharaben, Yang, Guangwei, Galvan, Manuel, Zhao, Yongsen, Fabrycki, Joanne, Luu, Amanda, Yang, Wengang, Phadke, Avinash, Wiles, Jason, Barrish, Joel, Huang, Mingjun, Podos, Steven D
Published in Immunobiology (1979) (01.10.2016)
Published in Immunobiology (1979) (01.10.2016)
Get full text
Journal Article
Assessment of complement-mediated bacterial killing and the effect of a small molecule factor D inhibitor in vitro
Zhao, Yongsen, Galvan, Manuel, Podos, Steven D, Thanassi, Jane A, Yang, Guangwei, Patel, Dharaben, Fabrycki, Joanne, Luu, Amanda, Yang, Wengang, Wiles, Jason, Phadke, Avinash, Barrish, Joel, Huang, Mingjun
Published in Immunobiology (1979) (01.10.2016)
Published in Immunobiology (1979) (01.10.2016)
Get full text
Journal Article
Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels−Alder reaction
Ji, Cheng, Lin, Weimin, Moraski, Garrett C., Thanassi, Jane A., Pucci, Michael J., Franzblau, Scott G., Möllmann, Ute, Miller, Marvin J.
Published in Bioorganic & medicinal chemistry (01.06.2012)
Published in Bioorganic & medicinal chemistry (01.06.2012)
Get full text
Journal Article
Dual Targeting of DNA Gyrase and Topoisomerase IV: Target Interactions of Heteroaryl Isothiazolones in Staphylococcus aureus
JIJUN CHENG, THANASSI, Jane A, THOMA, Christy L, BRADBURY, Barton J, DESHPANDE, Milind, PUCCI, Michael J
Published in Antimicrobial Agents and Chemotherapy (01.07.2007)
Published in Antimicrobial Agents and Chemotherapy (01.07.2007)
Get full text
Journal Article
Small molecule inhibitors of E. coli primase, a novel bacterial target
Agarwal, Atul, Louise-May, Shirley, Thanassi, Jane A., Podos, Steven D., Cheng, Jijun, Thoma, Christy, Liu, Cuixian, Wiles, Jason A., Nelson, David M., Phadke, Avinash S., Bradbury, Barton J., Deshpande, Milind S., Pucci, Michael J.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Get full text
Journal Article
In Vitro and In Vivo Antibacterial Activities of Heteroaryl Isothiazolones against Resistant Gram-Positive Pathogens
PUCCI, Michael J, JIJUN CHENG, PODOS, Steven D, THOMA, Christy L, THANASSI, Jane A, BUECHTER, Douglas D, MUSHTAQ, Gohar, VIGLIOTTI, Gerald A, BRADBURY, Barton J, DESHPANDE, Milind
Published in Antimicrobial Agents and Chemotherapy (01.04.2007)
Published in Antimicrobial Agents and Chemotherapy (01.04.2007)
Get full text
Journal Article
Isothiazoloquinolones with Enhanced Antistaphylococcal Activities against Multidrug-Resistant Strains: Effects of Structural Modifications at the 6-, 7-, and 8-Positions
Wang, Qiuping, Lucien, Edlaine, Hashimoto, Akihiro, Pais, Godwin C. G., Nelson, David M., Song, Yongsheng, Thanassi, Jane A., Marlor, Christopher W., Thoma, Christy L., Cheng, Jijun, Podos, Steven D., Ou, Yangsi, Deshpande, Milind, Pucci, Michael J., Buechter, Douglas D., Bradbury, Barton J., Wiles, Jason A.
Published in Journal of medicinal chemistry (25.01.2007)
Published in Journal of medicinal chemistry (25.01.2007)
Get full text
Journal Article
Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: Synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells
Wiles, Jason A., Wang, Qiuping, Lucien, Edlaine, Hashimoto, Akihiro, Song, Yongsheng, Cheng, Jijun, Marlor, Christopher W., Ou, Yangsi, Podos, Steven D., Thanassi, Jane A., Thoma, Christy L., Deshpande, Milind, Pucci, Michael J., Bradbury, Barton J.
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Get full text
Journal Article
Isothiazolopyridones: Synthesis, Structure, and Biological Activity of a New Class of Antibacterial Agents
Wiles, Jason A, Hashimoto, Akihiro, Thanassi, Jane A, Cheng, Jijun, Incarvito, Christopher D, Deshpande, Milind, Pucci, Michael J, Bradbury, Barton J
Published in Journal of medicinal chemistry (12.01.2006)
Published in Journal of medicinal chemistry (12.01.2006)
Get full text
Journal Article