Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5
Khathi, Samukelisiwe Pretty, Chandrasekaran, Balakumar, Karunanidhi, Sivanandhan, Tham, Chuin Lean, Kozielski, Frank, Sayyad, Nisar, Karpoormath, Rajshekhar
Published in Bioorganic & medicinal chemistry letters (15.09.2018)
Published in Bioorganic & medicinal chemistry letters (15.09.2018)
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A Single‐Stranded DNA‐Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks
Bassi, Gabriele, Favalli, Nicholas, Vuk, Miriam, Catalano, Marco, Martinelli, Adriano, Trenner, Anika, Porro, Antonio, Yang, Su, Tham, Chuin Lean, Moroglu, Mustafa, Yue, Wyatt W., Conway, Stuart J., Vogt, Peter K., Sartori, Alessandro A., Scheuermann, Jörg, Neri, Dario
Published in Advanced science (01.11.2020)
Published in Advanced science (01.11.2020)
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Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors
Talapatra, Sandeep K., Tham, Chuin Lean, Guglielmi, Paolo, Cirilli, Roberto, Chandrasekaran, Balakumar, Karpoormath, Rajshekhar, Carradori, Simone, Kozielski, Frank
Published in European journal of medicinal chemistry (05.08.2018)
Published in European journal of medicinal chemistry (05.08.2018)
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Corrigendum to “Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5 [Bioorg Med Chem Lett 28 (17) (2018) 2930–2938]”
Khathi, Samukelisiwe Pretty, Chandrasekaran, Balakumar, Karunanidhi, Sivanandhan, Tham, Chuin Lean, Kozielski, Frank, Sayyad, Nisar, Karpoormath, Rajshekhar
Published in Bioorganic & medicinal chemistry letters (15.11.2018)
Published in Bioorganic & medicinal chemistry letters (15.11.2018)
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Journal Article
Ligand- and structure-based in silico studies to identify kinesin spindle protein (KSP) inhibitors as potential anticancer agents
Balakumar, Chandrasekaran, Ramesh, Muthusamy, Tham, Chuin Lean, Khathi, Samukelisiwe Pretty, Kozielski, Frank, Srinivasulu, Cherukupalli, Hampannavar, Girish A., Sayyad, Nisar, Soliman, Mahmoud E., Karpoormath, Rajshekhar
Published in Journal of biomolecular structure & dynamics (26.10.2018)
Published in Journal of biomolecular structure & dynamics (26.10.2018)
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