BL-1249 [(5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: A Putative Potassium Channel Opener with Bladder-Relaxant Properties
Tertyshnikova, Svetlana, Knox, Ronald J, Plym, Mary Jane, Thalody, George, Griffin, Corinne, Neelands, Torben, Harden, David G, Signor, Laura, Weaver, David, Myers, Robert A, Lodge, Nicholas J
Published in The Journal of pharmacology and experimental therapeutics (01.04.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2005)
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Chemical genetics reveals an RGS/G-protein role in the action of a compound
Fitzgerald, Kevin, Tertyshnikova, Svetlana, Moore, Lisa, Bjerke, Lynn, Burley, Ben, Cao, Jian, Carroll, Pamela, Choy, Robert, Doberstein, Steve, Dubaquie, Yves, Franke, Yvonne, Kopczynski, Jenny, Korswagen, Hendrik, Krystek, Stanley R, Lodge, Nicholas J, Plasterk, Ronald, Starrett, John, Stouch, Terry, Thalody, George, Wayne, Honey, van der Linden, Alexander, Zhang, Yongmei, Walker, Stephen G, Cockett, Mark, Wardwell-Swanson, Judi, Ross-Macdonald, Petra, Kindt, Rachel M
Published in PLoS genetics (01.04.2006)
Published in PLoS genetics (01.04.2006)
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Assessing seizure liability using multi-electrode arrays (MEA)
Fan, Jingsong, Thalody, George, Kwagh, Jae, Burnett, Elisabeth, Shi, Hong, Lewen, Geoff, Chen, Shen-Jue, Levesque, Paul
Published in Toxicology in vitro (01.03.2019)
Published in Toxicology in vitro (01.03.2019)
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Partially purified Grammostola spatulata venom inhibits stretch activated calcium signaling in bladder myocytes and improves bladder compliance in an in vitro rat whole bladder model
Tertyshnikova, Svetlana, Matson, James A, Thalody, George, Lodge, Nicholas J
Published in The Journal of urology (01.02.2003)
Published in The Journal of urology (01.02.2003)
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Discovery of (S)‑1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein‑2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain
Luo, Guanglin, Chen, Ling, Kostich, Walter A., Hamman, Brian, Allen, Jason, Easton, Amy, Bourin, Clotilde, Gulianello, Michael, Lippy, Jonathan, Nara, Susheel, Maishal, Tarun Kumar, Thiyagarajan, Kamalraj, Jalagam, Prasadrao, Pattipati, Sreenivasulu Naidu, Dandapani, Kumaran, Dokania, Manoj, Vattikundala, Pradeep, Sharma, Vivek, Elavazhagan, Saravanan, Verma, Manoj Kumar, Das, Manish Lal, Wagh, Santosh, Balakrishnan, Anand, Johnson, Benjamin M., Santone, Kenneth S., Thalody, George, Denton, Rex, Saminathan, Hariharan, Holenarsipur, Vinay K., Kumar, Anoop, Rao, Abhijith, Putlur, Siva Prasad, Sarvasiddhi, Sarat Kumar, Shankar, Ganesh, Louis, Justin V., Ramarao, Manjunath, Conway, Charles M., Li, Yu-Wen, Pieschl, Rick, Tian, Yuan, Hong, Yang, Ditta, Jonathan, Mathur, Arvind, Li, Jianqing, Smith, Daniel, Pawluczyk, Joseph, Sun, Dawn, Yip, Shiuhang, Wu, Dauh-Rurng, Vetrichelvan, Muthalagu, Gupta, Anuradha, Wilson, Alan, Gopinathan, Suma, Wason, Suman, Bristow, Linda, Albright, Charles F., Bronson, Joanne J., Macor, John E., Dzierba, Carolyn D.
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
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Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain
Luo, Guanglin, Chen, Ling, Kostich, Walter A., Hamman, Brian, Allen, Jason, Easton, Amy, Bourin, Clotilde, Gulianello, Michael, Lippy, Jonathan, Nara, Susheel, Pattipati, Sreenivasulu Naidu, Dandapani, Kumaran, Dokania, Manoj, Vattikundala, Pradeep, Sharma, Vivek, Elavazhagan, Saravanan, Verma, Manoj Kumar, Lal Das, Manish, Wagh, Santosh, Balakrishnan, Anand, Johnson, Benjamin M., Santone, Kenneth S., Thalody, George, Denton, Rex, Saminathan, Hariharan, Holenarsipur, Vinay K., Kumar, Anoop, Rao, Abhijith, Putlur, Siva Prasad, Sarvasiddhi, Sarat Kumar, Shankar, Ganesh, Louis, Justin V., Ramarao, Manjunath, Conway, Charles M., Li, Yu-Wen, Pieschl, Rick, Tian, Yuan, Hong, Yang, Bristow, Linda, Albright, Charles F., Bronson, Joanne J., Macor, John E., Dzierba, Carolyn D.
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
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Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists
Mercer, Stephen E., Chaturvedula, Prasad V., Conway, Charles M., Cook, Deborah A., Davis, Carl D., Pin, Sokhom S., Macci, Robert, Schartman, Richard, Signor, Laura J., Widmann, Kimberly A., Whiterock, Valerie J., Chen, Ping, Xu, Cen, Herbst, John J., Kostich, Walter A., Thalody, George, Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (01.01.2021)
Published in Bioorganic & medicinal chemistry letters (01.01.2021)
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Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery
Chaturvedula, Prasad V., Mercer, Stephen E., Pin, Sokhom S., Thalody, George, Xu, Cen, Conway, Charlie M., Keavy, Deborah, Signor, Laura, Cantor, Glenn H., Mathias, Neil, Moench, Paul, Denton, Rex, Macci, Robert, Schartman, Richard, Whiterock, Valerie, Davis, Carl, Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
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Discovery of (R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): A Potent Antagonist of the Human Calcitonin Gene-Related Peptide Receptor for Migraine with Rapid and Efficient Intranasal Exposure
Degnan, Andrew P, Chaturvedula, Prasad V, Conway, Charles M, Cook, Deborah A, Davis, Carl D, Denton, Rex, Han, Xiaojun, Macci, Robert, Mathias, Neil R, Moench, Paul, Pin, Sokhom S, Ren, Shelly X, Schartman, Richard, Signor, Laura J, Thalody, George, Widmann, Kimberly A, Xu, Cen, Macor, John E, Dubowchik, Gene M
Published in Journal of medicinal chemistry (28.08.2008)
Published in Journal of medicinal chemistry (28.08.2008)
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The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2
Han, Xiaojun, Civiello, Rita L., Conway, Charles M., Cook, Deborah A., Davis, Carl D., Degnan, Andrew P., Jiang, Xiang-Jun, Macci, Robert, Mathias, Neil R., Moench, Paul, Pin, Sokhom S., Schartman, Richard, Signor, Laura J., Thalody, George, Tora, George, Whiterock, Valerie, Xu, Cen, Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
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Journal Article
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1
Han, Xiaojun, Civiello, Rita L., Conway, Charles M., Cook, Deborah A., Davis, Carl D., Macci, Robert, Pin, Sokhom S., Ren, Shelly X., Schartman, Richard, Signor, Laura J., Thalody, George, Widmann, Kimberly A., Xu, Cen, Chaturvedula, Prasad V., Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
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Cardiovascular liabilities of receptor X agonists using selective and non-selective compounds in telemetrized rats and knockout mice
Li, Julia P., Thalody, George, Lehman-McKeeman, Lois, Levesque, Paul C., Johnson, Verity K., Hennan, James K.
Published in Journal of pharmacological and toxicological methods (01.09.2012)
Published in Journal of pharmacological and toxicological methods (01.09.2012)
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Corrigendum to “The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2” [Bioorg. Med. Chem. Lett. 23 (2013) 1870–1873]
Han, Xiaojun, Civiello, Rita L., Conway, Charles M., Cook, Deborah A., Davis, Carl D., Degnan, Andrew P., Jiang, Xiang-Jun, Macci, Robert, Mathias, Neil R., Moench, Paul, Pin, Sokhom S., Schartman, Richard, Signor, Laura J., Thalody, George, Tora, George, Whiterock, Valerie, Xu, Cen, Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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Discovery of (R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidm-1-yl)piperidin-1-yl)propan-2-ylpiperidine-1-carboxamide (BMS-694153) : A Potent Antagonist of the Human Calcitonin Gene-Related Peptide Receptor for Migraine with Rapid and Efficient Intranasal Exposure
DEGNAN, Andrew P, CHATURVEDULA, Prasad V, PIN, Sokhom S, REN, Shelly X, SCHARTMAN, Richard, SIGNOR, Laura J, THALODY, George, WIDMANN, Kimberly A, CEN XU, MACOR, John E, DUBOWCHIK, Gene M, CONWAY, Charles M, COOK, Deborah A, DAVIS, Carl D, DENTON, Rex, XIAOJUN HAN, MACCI, Robert, MATHIAS, Neil R, MOENCH, Paul
Published in Journal of medicinal chemistry (2008)
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Published in Journal of medicinal chemistry (2008)
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The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: A new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for urge urinary incontinence
HEWAWASAM, Piyasena, ERWAY, Matthew, THALODY, George, WEINER, Harvey, BOISSARD, Christopher G, GRIBKOFF, Valentin K, MEANWELL, Nicholas A, LODGE, Nicholas, STARRETT, John E
Published in Bioorganic & medicinal chemistry letters (08.04.2002)
Published in Bioorganic & medicinal chemistry letters (08.04.2002)
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