Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells
Mimitou, Eleni P., Lareau, Caleb A., Chen, Kelvin Y., Zorzetto-Fernandes, Andre L., Hao, Yuhan, Takeshima, Yusuke, Luo, Wendy, Huang, Tse-Shun, Yeung, Bertrand Z., Papalexi, Efthymia, Thakore, Pratiksha I., Kibayashi, Tatsuya, Wing, James Badger, Hata, Mayu, Satija, Rahul, Nazor, Kristopher L., Sakaguchi, Shimon, Ludwig, Leif S., Sankaran, Vijay G., Regev, Aviv, Smibert, Peter
Published in Nature biotechnology (01.10.2021)
Published in Nature biotechnology (01.10.2021)
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Journal Article
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
Thakore, Pratiksha I, D'Ippolito, Anthony M, Song, Lingyun, Safi, Alexias, Shivakumar, Nishkala K, Kabadi, Ami M, Reddy, Timothy E, Crawford, Gregory E, Gersbach, Charles A
Published in Nature methods (01.12.2015)
Published in Nature methods (01.12.2015)
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Journal Article
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
Nelson, Christopher E., Hakim, Chady H., Ousterout, David G., Thakore, Pratiksha I., Moreb, Eirik A., Rivera, Ruth M. Castellanos, Madhavan, Sarina, Pan, Xiufang, Ran, F. Ann, Yan, Winston X., Asokan, Aravind, Zhang, Feng, Duan, Dongsheng, Gersbach, Charles A.
Published in Science (American Association for the Advancement of Science) (22.01.2016)
Published in Science (American Association for the Advancement of Science) (22.01.2016)
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Journal Article
RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors
Thakore, Pratiksha I., Kwon, Jennifer B., Nelson, Christopher E., Rouse, Douglas C., Gemberling, Matthew P., Oliver, Matthew L., Gersbach, Charles A.
Published in Nature communications (26.04.2018)
Published in Nature communications (26.04.2018)
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Journal Article
Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses
Wallrapp, Antonia, Burkett, Patrick R., Riesenfeld, Samantha J., Kim, Se-Jin, Christian, Elena, Abdulnour, Raja-Elie E., Thakore, Pratiksha I., Schnell, Alexandra, Lambden, Conner, Herbst, Rebecca H., Khan, Pavana, Tsujikawa, Kazutake, Xavier, Ramnik J., Chiu, Isaac M., Levy, Bruce D., Regev, Aviv, Kuchroo, Vijay K.
Published in Immunity (Cambridge, Mass.) (15.10.2019)
Published in Immunity (Cambridge, Mass.) (15.10.2019)
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Journal Article
Reading Frame Correction by Targeted Genome Editing Restores Dystrophin Expression in Cells From Duchenne Muscular Dystrophy Patients
Ousterout, David G, Perez-Pinera, Pablo, Thakore, Pratiksha I, Kabadi, Ami M, Brown, Matthew T, Qin, Xiaoxia, Fedrigo, Olivier, Mouly, Vincent, Tremblay, Jacques P, Gersbach, Charles A
Published in Molecular therapy (01.09.2013)
Published in Molecular therapy (01.09.2013)
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Journal Article
Correction of Dystrophin Expression in Cells From Duchenne Muscular Dystrophy Patients Through Genomic Excision of Exon 51 by Zinc Finger Nucleases
Ousterout, David G, Kabadi, Ami M, Thakore, Pratiksha I, Perez-Pinera, Pablo, Brown, Matthew T, Majoros, William H, Reddy, Timothy E, Gersbach, Charles A
Published in Molecular therapy (01.03.2015)
Published in Molecular therapy (01.03.2015)
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Journal Article
Gut CD4 + T cell phenotypes are a continuum molded by microbes, not by T H archetypes
Kiner, Evgeny, Willie, Elijah, Vijaykumar, Brinda, Chowdhary, Kaitavjeet, Schmutz, Hugo, Chandler, Jodie, Schnell, Alexandra, Thakore, Pratiksha I, LeGros, Graham, Mostafavi, Sara, Mathis, Diane, Benoist, Christophe
Published in Nature immunology (01.02.2021)
Published in Nature immunology (01.02.2021)
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Journal Article
Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy
Ousterout, David G., Kabadi, Ami M., Thakore, Pratiksha I., Majoros, William H., Reddy, Timothy E., Gersbach, Charles A.
Published in Nature communications (18.02.2015)
Published in Nature communications (18.02.2015)
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Journal Article
Knockdown of the Cell Cycle Inhibitor p21 Enhances Cartilage Formation by Induced Pluripotent Stem Cells
Diekman, Brian O., Thakore, Pratiksha I., O'Connor, Shannon K., Willard, Vincent P., Brunger, Jonathan M., Christoforou, Nicolas, Leong, Kam W., Gersbach, Charles A., Guilak, Farshid
Published in Tissue engineering. Part A (01.04.2015)
Published in Tissue engineering. Part A (01.04.2015)
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Journal Article
Cycling cancer persister cells arise from lineages with distinct programs
Oren, Yaara, Tsabar, Michael, Cuoco, Michael S., Amir-Zilberstein, Liat, Cabanos, Heidie F., Hütter, Jan-Christian, Hu, Bomiao, Thakore, Pratiksha I., Tabaka, Marcin, Fulco, Charles P., Colgan, William, Cuevas, Brandon M., Hurvitz, Sara A., Slamon, Dennis J., Deik, Amy, Pierce, Kerry A., Clish, Clary, Hata, Aaron N., Zaganjor, Elma, Lahav, Galit, Politi, Katerina, Brugge, Joan S., Regev, Aviv
Published in Nature (London) (26.08.2021)
Published in Nature (London) (26.08.2021)
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Journal Article
Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity
Schnell, Alexandra, Huang, Linglin, Singer, Meromit, Singaraju, Anvita, Barilla, Rocky M., Regan, Brianna M.L., Bollhagen, Alina, Thakore, Pratiksha I., Dionne, Danielle, Delorey, Toni M., Pawlak, Mathias, Meyer zu Horste, Gerd, Rozenblatt-Rosen, Orit, Irizarry, Rafael A., Regev, Aviv, Kuchroo, Vijay K.
Published in Cell (22.12.2021)
Published in Cell (22.12.2021)
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Journal Article
RNA-guided gene activation by CRISPR-Cas9–based transcription factors
Perez-Pinera, Pablo, Kocak, D Dewran, Vockley, Christopher M, Adler, Andrew F, Kabadi, Ami M, Polstein, Lauren R, Thakore, Pratiksha I, Glass, Katherine A, Ousterout, David G, Leong, Kam W, Guilak, Farshid, Crawford, Gregory E, Reddy, Timothy E, Gersbach, Charles A
Published in Nature methods (01.10.2013)
Published in Nature methods (01.10.2013)
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Journal Article
Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion
Frangieh, Chris J., Melms, Johannes C., Thakore, Pratiksha I., Geiger-Schuller, Kathryn R., Ho, Patricia, Luoma, Adrienne M., Cleary, Brian, Jerby-Arnon, Livnat, Malu, Shruti, Cuoco, Michael S., Zhao, Maryann, Ager, Casey R., Rogava, Meri, Hovey, Lila, Rotem, Asaf, Bernatchez, Chantale, Wucherpfennig, Kai W., Johnson, Bruce E., Rozenblatt-Rosen, Orit, Schadendorf, Dirk, Regev, Aviv, Izar, Benjamin
Published in Nature genetics (01.03.2021)
Published in Nature genetics (01.03.2021)
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Journal Article
Massively parallel phenotyping of coding variants in cancer with Perturb-seq
Ursu, Oana, Neal, James T., Shea, Emily, Thakore, Pratiksha I., Jerby-Arnon, Livnat, Nguyen, Lan, Dionne, Danielle, Diaz, Celeste, Bauman, Julia, Mosaad, Mariam Mounir, Fagre, Christian, Lo, April, McSharry, Maria, Giacomelli, Andrew O., Ly, Seav Huong, Rozenblatt-Rosen, Orit, Hahn, William C., Aguirre, Andrew J., Berger, Alice H., Regev, Aviv, Boehm, Jesse S.
Published in Nature biotechnology (01.06.2022)
Published in Nature biotechnology (01.06.2022)
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Journal Article
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes
Kiner, Evgeny, Willie, Elijah, Vijaykumar, Brinda, Chowdhary, Kaitavjeet, Schmutz, Hugo, Chandler, Jodie, Schnell, Alexandra, Thakore, Pratiksha I., LeGros, Graham, Mostafavi, Sara, Mathis, Diane, Benoist, Christophe
Published in Nature immunology (01.02.2021)
Published in Nature immunology (01.02.2021)
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Journal Article
Mostly natural sequencing-by-synthesis for scRNA-seq using Ultima sequencing
Simmons, Sean K., Lithwick-Yanai, Gila, Adiconis, Xian, Oberstrass, Florian, Iremadze, Nika, Geiger-Schuller, Kathryn, Thakore, Pratiksha I., Frangieh, Chris J., Barad, Omer, Almogy, Gilad, Rozenblatt-Rosen, Orit, Regev, Aviv, Lipson, Doron, Levin, Joshua Z.
Published in Nature biotechnology (01.02.2023)
Published in Nature biotechnology (01.02.2023)
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Journal Article
An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets
Zhang, Huiyuan, Madi, Asaf, Yosef, Nir, Chihara, Norio, Awasthi, Amit, Pot, Caroline, Lambden, Conner, Srivastava, Amitabh, Burkett, Patrick R., Nyman, Jackson, Christian, Elena, Etminan, Yasaman, Lee, Annika, Stroh, Helene, Xia, Junrong, Karwacz, Katarzyna, Thakore, Pratiksha I., Acharya, Nandini, Schnell, Alexandra, Wang, Chao, Apetoh, Lionel, Rozenblatt-Rosen, Orit, Anderson, Ana C., Regev, Aviv, Kuchroo, Vijay K.
Published in Cell reports (Cambridge) (24.11.2020)
Published in Cell reports (Cambridge) (24.11.2020)
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Journal Article
Editing the epigenome: technologies for programmable transcription and epigenetic modulation
Thakore, Pratiksha I, Black, Joshua B, Hilton, Isaac B, Gersbach, Charles A
Published in Nature methods (01.02.2016)
Published in Nature methods (01.02.2016)
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Journal Article
BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells
Thakore, Pratiksha I., Schnell, Alexandra, Huang, Linglin, Zhao, Maryann, Hou, Yu, Christian, Elena, Zaghouani, Sarah, Wang, Chao, Singh, Vasundhara, Singaraju, Anvita, Krishnan, Rajesh Kumar, Kozoriz, Deneen, Ma, Sai, Sankar, Venkat, Notarbartolo, Samuele, Buenrostro, Jason D., Sallusto, Federica, Patsopoulos, Nikolaos A., Rozenblatt-Rosen, Orit, Kuchroo, Vijay K., Regev, Aviv
Published in Nature immunology (01.08.2024)
Published in Nature immunology (01.08.2024)
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Journal Article