Chimeric bacteriocin S5-PmnH engineered by domain swapping efficiently controls Pseudomonas aeruginosa infection in murine keratitis and lung models
Paškevičius, Šarūnas, Dapkutė, Viktorija, Misiūnas, Audrius, Balzaris, Modestas, Thommes, Pia, Sattar, Abdul, Gleba, Yuri, Ražanskienė, Aušra
Published in Scientific reports (19.04.2022)
Published in Scientific reports (19.04.2022)
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Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K
Munck, Joanne M, Batey, Michael A, Zhao, Yan, Jenkins, Helen, Richardson, Caroline J, Cano, Celine, Tavecchio, Michele, Barbeau, Jody, Bardos, Julia, Cornell, Liam, Griffin, Roger J, Menear, Keith, Slade, Andrew, Thommes, Pia, Martin, Niall M B, Newell, David R, Smith, Graeme C M, Curtin, Nicola J
Published in Molecular cancer therapeutics (01.08.2012)
Published in Molecular cancer therapeutics (01.08.2012)
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4′-O-substitutions determine selectivity of aminoglycoside antibiotics
Perez-Fernandez, Déborah, Shcherbakov, Dmitri, Matt, Tanja, Leong, Ng Chyan, Kudyba, Iwona, Duscha, Stefan, Boukari, Heithem, Patak, Rashmi, Dubbaka, Srinivas Reddy, Lang, Kathrin, Meyer, Martin, Akbergenov, Rashid, Freihofer, Pietro, Vaddi, Swapna, Thommes, Pia, Ramakrishnan, V., Vasella, Andrea, Böttger, Erik C.
Published in Nature communications (28.01.2014)
Published in Nature communications (28.01.2014)
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Hydrophobic and charged residues in the C-terminal arm of hepatitis C virus RNA-dependent RNA polymerase regulate initiation and elongation
Cherry, Amy L, Dennis, Caitriona A, Baron, Andrew, Eisele, Leslie E, Thommes, Pia A, Jaeger, Joachim
Published in Journal of virology (01.02.2015)
Published in Journal of virology (01.02.2015)
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Journal Article
Characterization of the Xenopus replication licensing system
Chong, J P, Thömmes, P, Rowles, A, Mahbubani, H M, Blow, J J
Published in Methods in enzymology (1997)
Published in Methods in enzymology (1997)
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Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate
Slater, Martin J, Amphlett, Elizabeth M, Andrews, David M, Bravi, Gianpaolo, Burton, George, Cheasty, Anne G, Corfield, John A, Ellis, Malcolm R, Fenwick, Rebecca H, Fernandes, Stephanie, Guidetti, Rossella, Haigh, David, Hartley, C. David, Howes, Peter D, Jackson, Deborah L, Jarvest, Richard L, Lovegrove, Victoria L. H, Medhurst, Katrina J, Parry, Nigel R, Price, Helen, Shah, Pritom, Singh, Onkar M. P, Stocker, Richard, Thommes, Pia, Wilkinson, Claire, Wonacott, Alan
Published in Journal of medicinal chemistry (08.03.2007)
Published in Journal of medicinal chemistry (08.03.2007)
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Development of Cell-Based Assays for In Vitro Characterization of Hepatitis C Virus NS3/4A Protease Inhibitors
Chung, Victoria, Carroll, Anthony R, Gray, Norman M, Parry, Nigel R, Thommes, Pia A, Viner, K Claire, D'Souza, Eric A
Published in Antimicrobial Agents and Chemotherapy (01.04.2005)
Published in Antimicrobial Agents and Chemotherapy (01.04.2005)
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Intermittent micafungin for prophylaxis in a rat model of chronic Candida albicans gut colonization
Warn, Peter, Thommes, Pia, Sharp, Andrew, Sattar, Abdul, Undre, Nasrullah, Palacios-Fabrega, Jose Alejandro, Karas, Andreas
Published in Journal of antimicrobial chemotherapy (01.10.2020)
Published in Journal of antimicrobial chemotherapy (01.10.2020)
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Abstract 3928: KU-0060019, a novel small molecule inhibitor of ATM
Shea, Kerry F., Albertella, Mark, Bárdos, Julia, Batey, Michael A., Cranston, Aaron, Curtin, Nicola, Griffin, Roger, Lau, Alan, Menear, Keith, Newell, David, O'Connor, Mark, Richardson, Caroline, Jones, Louise, Smith, Graeme, Thömmes, Pia, Zhao, Yan, Martin, Niall
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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SMT19969 for Clostridium difficile infection (CDI): in vivo efficacy compared with fidaxomicin and vancomycin in the hamster model of CDI
Sattar, Abdul, Thommes, Pia, Payne, Lloyd, Warn, Peter, Vickers, Richard J
Published in Journal of antimicrobial chemotherapy (01.06.2015)
Published in Journal of antimicrobial chemotherapy (01.06.2015)
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Discovery of 4‑{4-[(3R)‑3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}‑1H‑indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity
Foote, Kevin M, Blades, Kevin, Cronin, Anna, Fillery, Shaun, Guichard, Sylvie S, Hassall, Lorraine, Hickson, Ian, Jacq, Xavier, Jewsbury, Philip J, McGuire, Thomas M, Nissink, J. Willem M, Odedra, Rajesh, Page, Ken, Perkins, Paula, Suleman, Abid, Tam, Kin, Thommes, Pia, Broadhurst, Rebecca, Wood, Christine
Published in Journal of medicinal chemistry (14.03.2013)
Published in Journal of medicinal chemistry (14.03.2013)
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Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein
Thommes, Pia, Fett, Radegunde, Schray, Beate, Burkhart, Roland, Barnes, Marjorie, Kennedy, Chris, Brown, Neal C., Knippers, Rolf
Published in Nucleic acids research (11.03.1992)
Published in Nucleic acids research (11.03.1992)
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Disease Progression and Resolution in Rodent Models of Clostridium difficile Infection and Impact of Antitoxin Antibodies and Vancomycin
Warn, Peter, Thommes, Pia, Sattar, Abdul, Corbett, David, Flattery, Amy, Zhang, Zuo, Black, Todd, Hernandez, Lorraine D, Therien, Alex G
Published in Antimicrobial agents and chemotherapy (01.11.2016)
Published in Antimicrobial agents and chemotherapy (01.11.2016)
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The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides
Thömmes, Pia, Kubota, Yumiko, Takisawa, Haruhiko, Blow, J.Julian
Published in The EMBO journal (02.06.1997)
Published in The EMBO journal (02.06.1997)
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Discovery of Novel UDP‑N‑Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa
Ryan, M. Dominic, Parkes, Alastair L, Corbett, David, Dickie, Anthony P, Southey, Michelle, Andersen, Ole A, Stein, Daniel B, Barbeau, Olivier R, Sanzone, Angelo, Thommes, Pia, Barker, John, Cain, Ricky, Compper, Christel, Dejob, Magali, Dorali, Alain, Etheridge, Donnya, Evans, Sian, Faulkner, Adele, Gadouleau, Elise, Gorman, Timothy, Haase, Denes, Holbrow-Wilshaw, Maisie, Krulle, Thomas, Li, Xianfu, Lumley, Christopher, Mertins, Barbara, Napier, Spencer, Odedra, Rajesh, Papadopoulos, Kostas, Roumpelakis, Vasileios, Spear, Kate, Trimby, Emily, Williams, Jennifer, Zahn, Michael, Keefe, Anthony D, Zhang, Ying, Soutter, Holly T, Centrella, Paolo A, Clark, Matthew A, Cuozzo, John W, Dumelin, Christoph E, Deng, Boer, Hunt, Avery, Sigel, Eric A, Troast, Dawn M, DeJonge, Boudewijn L. M
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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1-Substituted (Dibenzo[ b,d ]thiophen-4-yl)-2-morpholino-4 H -chromen-4-ones Endowed with Dual DNA-PK/PI3-K Inhibitory Activity
Cano, Céline, Saravanan, Kappusamy, Bailey, Chris, Bardos, Julia, Curtin, Nicola J., Frigerio, Mark, Golding, Bernard T., Hardcastle, Ian R., Hummersone, Marc G., Menear, Keith A., Newell, David R., Richardson, Caroline J., Shea, K., Smith, Graeme C. M., Thommes, Pia, Ting, Attilla, Griffin, Roger J.
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
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