Antisense‐mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first‐in‐human randomized, placebo‐controlled trial
Poelgeest, Eveline P., Hodges, Michael R., Moerland, Matthijs, Tessier, Yann, Levin, Arthur A., Persson, Robert, Lindholm, Marie W., Dumong Erichsen, Kamille, Ørum, Henrik, Cohen, Adam F., Burggraaf, Jacobus
Published in British journal of clinical pharmacology (01.12.2015)
Published in British journal of clinical pharmacology (01.12.2015)
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Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia
Sewing, Sabine, Roth, Adrian B, Winter, Michael, Dieckmann, Andreas, Bertinetti-Lapatki, Cristina, Tessier, Yann, McGinnis, Claudia, Huber, Sylwia, Koller, Erich, Ploix, Corinne, Reed, John C, Singer, Thomas, Rothfuss, Andreas
Published in PloS one (06.11.2017)
Published in PloS one (06.11.2017)
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Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs
Sewing, Sabine, Boess, Franziska, Moisan, Annie, Bertinetti-Lapatki, Cristina, Minz, Tanja, Hedtjaern, Maj, Tessier, Yann, Schuler, Franz, Singer, Thomas, Roth, Adrian B
Published in PloS one (21.07.2016)
Published in PloS one (21.07.2016)
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Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny
Valenzuela, Allan, Ayuso, Miriam, Buyssens, Laura, Bars, Chloé, Van Ginneken, Chris, Tessier, Yann, Van Cruchten, Steven
Published in Pharmaceutics (31.03.2023)
Published in Pharmaceutics (31.03.2023)
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Journal Article
Acute Kidney Injury During Therapy With an Antisense Oligonucleotide Directed Against PCSK9
van Poelgeest, Eveline P., MD, Swart, Reinout M., MD, Betjes, Michiel G.H., MD, Moerland, Matthijs, PhD, Weening, Jan J., MD, Tessier, Yann, DVM, Hodges, Michael R., MD, Levin, Arthur A., PhD, Burggraaf, Jacobus, MD, PhD
Published in American journal of kidney diseases (01.10.2013)
Published in American journal of kidney diseases (01.10.2013)
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Journal Article
Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Göttingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases
Valenzuela, Allan, Tardiveau, Claire, Ayuso, Miriam, Buyssens, Laura, Bars, Chloe, Van Ginneken, Chris, Fant, Pierluigi, Leconte, Isabelle, Braendli-Baiocco, Annamaria, Parrott, Neil, Schmitt, Georg, Tessier, Yann, Barrow, Paul, Van Cruchten, Steven
Published in Pharmaceutics (10.09.2021)
Published in Pharmaceutics (10.09.2021)
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Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling
Moisan, Annie, Gubler, Marcel, Zhang, Jitao David, Tessier, Yann, Dumong Erichsen, Kamille, Sewing, Sabine, Gérard, Régine, Avignon, Blandine, Huber, Sylwia, Benmansour, Fethallah, Chen, Xing, Villaseñor, Roberto, Braendli-Baiocco, Annamaria, Festag, Matthias, Maunz, Andreas, Singer, Thomas, Schuler, Franz, Roth, Adrian B.
Published in Molecular therapy. Nucleic acids (17.03.2017)
Published in Molecular therapy. Nucleic acids (17.03.2017)
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A Low-Cost and Simple Imaging Technique of the Anterior and Posterior Segments: Eye Fundus, Ciliary Bodies, Iridocorneal Angle
Guyomard, Jean-Laurent, Rosolen, Serge G, Paques, Michel, Delyfer, Marie-Noelle, Simonutti, Manuel, Tessier, Yann, Sahel, Jose A, Legargasson, Jean-Francois, Picaud, Serge
Published in Investigative ophthalmology & visual science (01.11.2008)
Published in Investigative ophthalmology & visual science (01.11.2008)
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Platelet Activation by Antisense Oligonucleotides Ontogeny
Valenzuela, Allan, Ayuso, Miriam, Buyssens, Laura, Bars, Chloé, Van Ginneken, Chris, Tessier, Yann, Van Cruchten, Steven
Published in Pharmaceutics (01.03.2023)
Published in Pharmaceutics (01.03.2023)
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Outcomes of the European Federation of Pharmaceutical Industries and Associations Oligonucleotide Working Group Survey on Nonclinical Practices and Regulatory Expectations for Therapeutic Oligonucleotide Safety Assessment
Tessier, Yann, Achanzar, William, Mihalcik, Lauren, Amuzie, Chidozie, Andersson, Patrik, Parry, Joel D, Moggs, Jonathan, Whiteley, Laurence O
Published in Nucleic acid therapeutics (01.02.2021)
Published in Nucleic acid therapeutics (01.02.2021)
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The Angers CT Score is a Risk Factor for the Failure of the Conservative Management of Adhesive Small Bowel Obstruction: A Prospective Observational Multicentric Study
Paisant, Anita, Burgmaier, Jeanne, Calame, Paul, Loison, Mélanie, Molière, Sébastien, Brigand, Cécile, Belabbas, Dihia, Duchalais, Emilie, Regimbeau, Jean-Marc, Yzet, Thierry, Alves, Arnaud, Fohlen, Audrey, Bergeat, Damien, Vauclair, Estelle, Pellegrini, Julie, Ragot, Emilia, Lansier, Alexandre, Abet, Emeric, Nevot, Alexandre, Rousset, Pascal, Ouaissi, Mehdi, Besson, Marie, Ronot, Maxime, Giacca, Massimo, Girard, Edouard, Tessier, Yann, Massalou, Damien, Poirier, Florent, Lakkis, Zaher, Aubé, Christophe, Hamel, Jean Francois, Passot, Guillaume, Venara, Aurélien
Published in World journal of surgery (01.04.2023)
Published in World journal of surgery (01.04.2023)
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Journal Article
Cardiovascular effects of RTR2996, a single stranded oligonucleotide, in the minipig
Roberts, Sonia, Greiter-Wilke, Andrea, Waiz, David, Jenni, Roland, Weile, Christian, Zihlmann, Marco, Tessier, Yann, Braendli-Baiocco, Annamaria, Festag, Matthias
Published in Journal of pharmacological and toxicological methods (01.09.2019)
Published in Journal of pharmacological and toxicological methods (01.09.2019)
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Journal Article
Gene expression profiling of key nucleases in the juvenile Göttingen minipig
Valenzuela, Allan Paulo, Buyssens, Laura, Bars, Chloé, Ayuso, Miriam, Van Ginneken, Chris, Parrott, Neil, Tessier, Yann, Schmitt, Georg, Barrow, Paul, Van Cruchten, Steven
Published in Reproductive toxicology (Elmsford, N.Y.) (01.09.2019)
Published in Reproductive toxicology (Elmsford, N.Y.) (01.09.2019)
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Journal Article
Locked nucleic acid (LNA)‐based single‐stranded oligonucleotides are not genotoxic
Guérard, Melanie, Andreas, Zeller, Erich, Koller, Christine, Marchand, Martina, Müller B., Christian, Weile, Franz, Schuler, Thomas, Singer, Yann, Tessier
Published in Environmental and molecular mutagenesis (01.04.2017)
Published in Environmental and molecular mutagenesis (01.04.2017)
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Journal Article
The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides
Braendli-Baiocco, A, Festag, M, Dumong-Erichsen, K, Persson, R, Mihatsch, MJ, Fisker, N, Funk, J, Mohr, S, Constien, R, Ploix, C, Brady, K, Berrera, M, Altmann, B, Lenz, B, Albassam, M, Schmitt, G, Weiser, T, Schuler, F, Singer, T, Tessier, Y
Published in Toxicological sciences (01.05.2017)
Published in Toxicological sciences (01.05.2017)
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From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides
Braendli-Baiocco, Annamaria, Festag, Matthias, Dumong Erichsen, Kamille, Persson, Robert, Mihatsch, Michael J, Fisker, Niels, Funk, Juergen, Mohr, Susanne, Constien, Rainer, Ploix, Corinne, Brady, Kevin, Berrera, Marco, Altmann, Bernd, Lenz, Barbara, Albassam, Mudher, Schmitt, Georg, Weiser, Thomas, Schuler, Franz, Singer, Thomas, Tessier, Yann
Published in Toxicological sciences (01.05.2017)
Published in Toxicological sciences (01.05.2017)
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Journal Article
Abstracts8th Annual Meeting of the Oligonucleotide Therapeutics SocietyBoston, MassachusettsOctober 28–31, 2012
Sharp, Phillip A., Maraganore, John, Crooke, Stanley T., Babar, Imran, Janowski, Bethany A., Matsui, Masayuki, Zhang, Huiying, Gagnon, Keith, Shaikh, Sarfraz, Meister, Gunter, Hirsch, Markus, Juliano, Rudy, Fisher, Michael, MacRae, Ian, Butora, Gabor, Matsuda, Akira, Minakawa, Noriaki, Tuschl, Thomas, Williams, Zev, Renwick, Neil, Hafner, Markus, Jiang, Tian, Dela-Moss, Indee, Kierzek, Ryszard, Kierzek, Elzbieta, Ellington, Andy, Seth, Punit, Peng, Chang Geng, Chan, Amy, Charisse, Klaus, Maier, Martin, Fitzgerald, Kevin, Jadhav, Vasant, Jayaraman, Muthusamy, Landesman, Yosef, Zhang, Xuemei, Hutabarat, Renta, Kumar, Varun, Rajeev, Kallanthottathil G., Mui, Barbara L., Du, Xinyao, Hope, Michael J., Madden, Thomas D., Cullis, Pieter, Akinc, Akin, Lewis, David, Hossbach, Markus, Chu, Qili, Klein, Jason J., Wakefield, Darren H., Oropeza, Claudia E., Roehl, Ingo, Vornlocher, Hans-Peter, Sarnow, Peter, Machlin, Erica, Sagan, Selena, Guo, Shuling, Booten, Sheri L., Hung, Gene, Blomenkamp, Keith, Teckman, Jeffery H., McCaleb, Michael L., Monia, Brett P., Akinc, Akin, Sehgal, Alfica, Brodsky, Josh, Qin, June, Foster, Don, Mirkin, Chad, Mitrpant, Charlermchai, McGovern, Vicki, Bevan, Adam, Thornton, Charles, Wheeler, Thurman M., Leger, Andrew J., Pandey, Sanjay K., Wentworth, Bruce M., Lieberman, J., Wheeler, LA, Basar, E, Seung, E, Deruaz, M, Luster, AD, Tager, AM, Patick, Amy, Tessier, Yann, Perssonv, Robert, Sandberg, Bente C., Nochur, Sara, Ftizgerlad, Kevin, Gollob, Jared, Monia, Brett, Müller, Philipp, Jensen, Jeff J., Henry, Scott P., Levin, Art, Lindow, Morten, Lawrence, Christine, Sciabola, Simone, Rotstein, Sergio
Published in Nucleic acid therapeutics (01.12.2012)
Published in Nucleic acid therapeutics (01.12.2012)
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