Strategies for delivering therapeutics across the blood–brain barrier
Terstappen, Georg C., Meyer, Axel H., Bell, Robert D., Zhang, Wandong
Published in Nature reviews. Drug discovery (01.05.2021)
Published in Nature reviews. Drug discovery (01.05.2021)
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Journal Article
A call for better understanding of target engagement in Tau antibody development
Bespalov, Anton, Courade, Jean-Philippe, Khiroug, Leonard, Terstappen, Georg C., Wang, Yipeng
Published in Drug discovery today (01.11.2022)
Published in Drug discovery today (01.11.2022)
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Target deconvolution strategies in drug discovery
Terstappen, Georg C, Schlüpen, Christina, Raggiaschi, Roberto, Gaviraghi, Giovanni
Published in Nature reviews. Drug discovery (01.11.2007)
Published in Nature reviews. Drug discovery (01.11.2007)
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Journal Article
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development
Loryan, Irena, Reichel, Andreas, Feng, Bo, Bundgaard, Christoffer, Shaffer, Christopher, Kalvass, Cory, Bednarczyk, Dallas, Morrison, Denise, Lesuisse, Dominique, Hoppe, Edmund, Terstappen, Georg C., Fischer, Holger, Di, Li, Colclough, Nicola, Summerfield, Scott, Buckley, Stephen T., Maurer, Tristan S., Fridén, Markus
Published in Pharmaceutical research (01.07.2022)
Published in Pharmaceutical research (01.07.2022)
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Combining experimental strategies for successful target deconvolution
Wilkinson, Isabel V.L., Terstappen, Georg C., Russell, Angela J.
Published in Drug discovery today (01.11.2020)
Published in Drug discovery today (01.11.2020)
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Journal Article
Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease
Rosi, Maria Cristina, Luccarini, Ilaria, Grossi, Cristina, Fiorentini, Anna, Spillantini, Maria Grazia, Prisco, Antonella, Scali, Carla, Gianfriddo, Marco, Caricasole, Andrea, Terstappen, Georg C, Casamenti, Fiorella
Published in Journal of neurochemistry (01.03.2010)
Published in Journal of neurochemistry (01.03.2010)
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Journal Article
Drug Distribution into Peripheral Nerve
Liu, Houfu, Chen, Yan, Huang, Liang, Sun, Xueying, Fu, Tingting, Wu, Shengqian, Zhu, Xiaoyan, Zhen, Wei, Liu, Jihong, Lu, Gang, Cai, Wei, Yang, Ting, Zhang, Wandong, Yu, Xiaohong, Wan, Zehong, Wang, Jianfei, Summerfield, Scott G, Dong, Kelly, Terstappen, Georg C
Published in The Journal of pharmacology and experimental therapeutics (01.05.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2018)
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Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs
Li, Yuan, Sun, Xueying, Liu, Houfu, Huang, Liang, Meng, Guofeng, Ding, Yu, Su, Wenji, Lu, Jiaqi, Gong, Sophie, Terstappen, Georg C., Zhang, Ru, Zhang, Wandong
Published in Neuroscience bulletin (01.12.2019)
Published in Neuroscience bulletin (01.12.2019)
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Brain delivery research in public-private partnerships: The IMI-JU COMPACT consortium as an example
Meyer, Axel H., Untucht, Christopher, Terstappen, Georg C.
Published in Neuropharmacology (01.07.2017)
Published in Neuropharmacology (01.07.2017)
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Journal Article
Label-free detection of small-molecule binding to a GPCR in the membrane environment
Heym, Roland G., Hornberger, Wilfried B., Lakics, Viktor, Terstappen, Georg C.
Published in Biochimica et biophysica acta (01.08.2015)
Published in Biochimica et biophysica acta (01.08.2015)
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Journal Article
Generating Human iPSC-Derived Astrocytes with Chemically Defined Medium for In Vitro Disease Modeling
Janssen, Katharina, Bahnassawy, Lamiaa, Kiefer, Claudia, Korffmann, Jürgen, Terstappen, Georg C, Lakics, Viktor, Cik, Miroslav, Reinhardt, Peter
Published in Methods in molecular biology (Clifton, N.J.) (2019)
Published in Methods in molecular biology (Clifton, N.J.) (2019)
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Endothelial Cell Adhesion to the Extracellular Matrix Induces c-Src–Dependent VEGFR-3 Phosphorylation Without the Activation of the Receptor Intrinsic Kinase Activity
Galvagni, Federico, Pennacchini, Susanna, Salameh, Ahmad, Rocchigiani, Marina, Neri, Francesco, Orlandini, Maurizio, Petraglia, Felice, Gotta, Stefano, Sardone, Gian Luca, Matteucci, Giacomo, Terstappen, Georg C, Oliviero, Salvatore
Published in Circulation research (25.06.2010)
Published in Circulation research (25.06.2010)
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Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain
Caricasole, Andrea, Copani, Agata, Caraci, Filippo, Aronica, Eleonora, Rozemuller, Annemieke J, Caruso, Alessandra, Storto, Marianna, Gaviraghi, Giovanni, Terstappen, Georg C, Nicoletti, Ferdinando
Published in The Journal of neuroscience (30.06.2004)
Published in The Journal of neuroscience (30.06.2004)
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Journal Article
Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades
Delille, Hannah K., Becker, Judith M., Burkhardt, Sabrina, Bleher, Barbara, Terstappen, Georg C., Schmidt, Martin, Meyer, Axel H., Unger, Liliane, Marek, Gerard J., Mezler, Mario
Published in Neuropharmacology (01.06.2012)
Published in Neuropharmacology (01.06.2012)
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Journal Article
Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1
Scali, Carla, Caraci, Filippo, Gianfriddo, Marco, Diodato, Enrica, Roncarati, Renza, Pollio, Giuseppe, Gaviraghi, Giovanni, Copani, Agata, Nicoletti, Ferdinando, Terstappen, Georg C., Caricasole, Andrea
Published in Neurobiology of disease (01.11.2006)
Published in Neurobiology of disease (01.11.2006)
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Journal Article
Targeting mutant huntingtin for the development of disease-modifying therapy
Appl, Thomas, Kaltenbach, Linda, Lo, Donald C., Terstappen, Georg C.
Published in Drug discovery today (01.11.2012)
Published in Drug discovery today (01.11.2012)
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Journal Article
Trafficking of JC virus-like particles across the blood-brain barrier
Ye, Dong, Zimmermann, Tina, Demina, Victoria, Sotnikov, Sergey, Ried, Christian L, Rahn, Harri, Stapf, Marcus, Untucht, Christopher, Rohe, Michael, Terstappen, Georg C, Wicke, Karsten, Mezler, Mario, Manninga, Heiko, Meyer, Axel H
Published in Nanoscale advances (04.05.2021)
Published in Nanoscale advances (04.05.2021)
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Journal Article
Screening technologies for ion channel drug discovery
Terstappen, Georg C, Roncarati, Renza, Dunlop, John, Peri, Ravikumar
Published in Future medicinal chemistry (01.05.2010)
Published in Future medicinal chemistry (01.05.2010)
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