E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition
Chen, Augustine, Beetham, Henry, Black, Michael A, Priya, Rashmi, Telford, Bryony J, Guest, Joanne, Wiggins, George A R, Godwin, Tanis D, Yap, Alpha S, Guilford, Parry J
Published in BMC cancer (30.07.2014)
Published in BMC cancer (30.07.2014)
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E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function
Godwin, Tanis D., Kelly, S. Thomas, Brew, Tom P., Bougen-Zhukov, Nicola M., Single, Andrew B., Chen, Augustine, Stylianou, Cassie E., Harris, Lawrence D., Currie, Sophie K., Telford, Bryony J., Beetham, Henry G., Evans, Gary B., Black, Michael A., Guilford, Parry J.
Published in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (01.03.2019)
Published in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (01.03.2019)
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Transcriptome-wide analysis reveals insight into tumor suppressor functions of 1B3, a novel synthetic miR-193a-3p mimic
van den Bosch, Marion T.J., Yahyanejad, Sanaz, Alemdehy, Mir Farshid, Telford, Bryony J., de Gunst, Thijs, den Boer, Harm C., Vos, Rogier M., Stegink, Marieke, van Pinxteren, Laurens A.H., Schaapveld, Roel Q.J., Janicot, Michel
Published in Molecular therapy. Nucleic acids (05.03.2021)
Published in Molecular therapy. Nucleic acids (05.03.2021)
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A high-throughput screen to identify novel synthetic lethal compounds for the treatment of E-cadherin-deficient cells
Beetham, Henry, Chen, Augustine, Telford, Bryony J, Single, Andrew, Jarman, Kate E, Lackovic, Kurt, Luxenburger, Andreas, Guilford, Parry
Published in Scientific reports (29.08.2019)
Published in Scientific reports (29.08.2019)
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INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death
Duurland, Chantal L., Gunst, Thijs de, Boer, Harm C. den, Bosch, Marion T.J. van den, Telford, Bryony J., Vos, Rogier M., Xie, Xiaolei, Zang, Mingfa, Wang, Fang, Shao, Yingying, An, Xiaoyu, Wang, Jingjing, Cai, Jie, Bourré, Ludovic, Pinxteren, Laurens A.H. van, Schaapveld, Roel Q.J., Janicot, Michel, Yahyanejad, Sanaz
Published in Oncotarget (12.07.2024)
Published in Oncotarget (12.07.2024)
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Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology
Telford, Bryony J, Yahyanejad, Sanaz, de Gunst, Thijs, den Boer, Harm C, Vos, Rogier M, Stegink, Marieke, van den Bosch, Marion T J, Alemdehy, Mir Farshid, van Pinxteren, Laurens A H, Schaapveld, Roel Q J, Janicot, Michel
Published in Oncotarget (02.03.2021)
Published in Oncotarget (02.03.2021)
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Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin-Deficient Cells
Telford, Bryony J, Chen, Augustine, Beetham, Henry, Frick, James, Brew, Tom P, Gould, Cathryn M, Single, Andrew, Godwin, Tanis, Simpson, Kaylene J, Guilford, Parry
Published in Molecular cancer therapeutics (01.05.2015)
Published in Molecular cancer therapeutics (01.05.2015)
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The tumor suppressor 5A2, a synthetic miR-7-5p mimic, targets oncogenic and metabolic pathways, as revealed by transcriptome-wide analysis
van den Bosch, Marion T. J., Telford, Bryony J., Yahyanejad, Sanaz, de Gunst, Thijs, den Boer, Harm C., Vos, Rogier M., Duurland, Chantal L., Biemans, Rianne, Dubois, Ludwig J., van Pinxteren, Laurens A. H., Schaapveld, Roel Q. J., Janicot, Michel
Published in Frontiers in drug discovery (07.07.2023)
Published in Frontiers in drug discovery (07.07.2023)
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