Fazirsiran for Liver Disease Associated with Alpha1-Antitrypsin Deficiency
Strnad, Pavel, Mandorfer, Mattias, Choudhury, Gourab, Griffiths, William, Trautwein, Christian, Loomba, Rohit, Schluep, Thomas, Chang, Ting, Yi, Min, Given, Bruce D., Hamilton, James C., San Martin, Javier, Teckman, Jeffery H.
Published in The New England journal of medicine (11.08.2022)
Published in The New England journal of medicine (11.08.2022)
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Journal Article
Hepatic-targeted RNA interference provides robust and persistent knockdown of alpha-1 antitrypsin levels in ZZ patients
Turner, Alice M., Stolk, Jan, Bals, Robert, Lickliter, Jason D., Hamilton, James, Christianson, Dawn R., Given, Bruce D., Burdon, Jonathan G., Loomba, Rohit, Stoller, James K., Teckman, Jeffery H.
Published in Journal of hepatology (01.08.2018)
Published in Journal of hepatology (01.08.2018)
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Journal Article
Antisense oligonucleotide treatment ameliorates alpha-1 antitrypsin-related liver disease in mice
Guo, Shuling, Booten, Sheri L, Aghajan, Mariam, Hung, Gene, Zhao, Chenguang, Blomenkamp, Keith, Gattis, Danielle, Watt, Andrew, Freier, Susan M, Teckman, Jeffery H, McCaleb, Michael L, Monia, Brett P
Published in The Journal of clinical investigation (01.01.2014)
Published in The Journal of clinical investigation (01.01.2014)
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Oleanolic Acid Improves Gut Atrophy Induced by Parenteral Nutrition
Jain, Ajay Kumar, Wen, Joy X, Blomenkamp, Keith S, Arora, Sumit, Blaufuss, Timothy A, Rodrigues, Jonathan, Long, John P, Neuschwander-Tetri, Brent A, Teckman, Jeffery H
Published in JPEN. Journal of parenteral and enteral nutrition (01.01.2016)
Published in JPEN. Journal of parenteral and enteral nutrition (01.01.2016)
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Journal Article
Preserved Gut Microbial Diversity Accompanies Upregulation of TGR5 and Hepatobiliary Transporters in Bile Acid-Treated Animals Receiving Parenteral Nutrition
Jain, Ajay Kumar, Sharma, Abhineet, Arora, Sumit, Blomenkamp, Keith, Jun, Ik Chan, Luong, Robert, Westrich, David John, Mittal, Aayush, Buchanan, Paula M, Guzman, Miguel A, Long, John, Neuschwander-Tetri, Brent A, Teckman, Jeffery
Published in JPEN. Journal of parenteral and enteral nutrition (01.02.2017)
Published in JPEN. Journal of parenteral and enteral nutrition (01.02.2017)
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Journal Article
Validating hyperbilirubinemia and gut mucosal atrophy with a novel ultramobile ambulatory total parenteral nutrition piglet model
Jain, Ajay K, Wen, Joy X, Arora, Sumit, Blomenkamp, Keith S, Rodrigues, Jonathan, Blaufuss, Timothy A, Liou, Victor, Burrin, Douglas G, Long, John P, Teckman, Jeffery H
Published in Nutrition research (New York, N.Y.) (01.02.2015)
Published in Nutrition research (New York, N.Y.) (01.02.2015)
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Journal Article
Alpha‐1‐Antitrypsin Deficiency
Suri, Anandini, Patel, Dhiren, Teckman, Jeffery
Published in Clinical liver disease (Malden, Mass.) (01.03.2022)
Published in Clinical liver disease (Malden, Mass.) (01.03.2022)
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Journal Article
Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles
Mueller, Christian, Tang, Qiushi, Gruntman, Alisha, Blomenkamp, Keith, Teckman, Jeffery, Song, Lina, Zamore, Phillip D, Flotte, Terence R
Published in Molecular therapy (01.03.2012)
Published in Molecular therapy (01.03.2012)
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Journal Article
Fazirsiran for Liver Disease Associated with Alpha 1 -Antitrypsin Deficiency
Strnad, Pavel, Mandorfer, Mattias, Choudhury, Gourab, Griffiths, William, Trautwein, Christian, Loomba, Rohit, Schluep, Thomas, Chang, Ting, Yi, Min, Given, Bruce D., Hamilton, James C., San Martin, Javier, Teckman, Jeffery H.
Published in The New England journal of medicine (11.08.2022)
Published in The New England journal of medicine (11.08.2022)
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Journal Article
Risk of variceal hemorrhage and pretransplant mortality in children with biliary atresia
Bass, Lee M., Ye, Wen, Leung, Daniel H., Murray, Karen F., Molleston, Jean P., Romero, Rene, Rosenthal, Philip, Loomes, Kathleen M., Wang, Kasper S., Squires, Robert H., Miethke, Alexander, Ng, Vicky L., Kyle Jensen, M., Sokol, Ronald J., Magee, John C., Alonso, Estella, Bass, Lee, Kelly, Susan, Melin‐Aldana, Hector, Bove, Kevin, Heubi, James, Miethke, Alexander, Tiao, Greg, Chapman, Erin, Sokol, Ronald, Feldman, Amy, Mack, Cara, Narkewicz, Michael, Sundaram, Shikha, Van Hove, Johan, Garcia, Benigno, Kauma, Mikaela, Kocher, Kendra, Steinbeiss, Matthew, Lovell, Mark, Loomes, Kathleen, Rand, Elizabeth, Russo, Pierre, Spinner, Nancy, Erlichman, Jessi, Pakstis, Dina, King, Sakya, Squires, Robert, Sindhi, Rakesh, Venkat, Veena, McKiernan, Patrick, Haberstroh, Lori, Curry, Joanna, Langlois, Camille, Kim, Grace, Teckman, Jeffery, Kociela, Vikki, Nagy, Rosemary, Patel, Shraddha, Cerkoski, Jacqueline, Bozic, Molly, Subbarao, Girish, Klipsch, Ann, Cummings, Oscar, Hsu, Evelyn, Cooper, Kara, Young, Melissa, Finn, Laura, Kamath, Binita, Ng, Vicky, Quammie, Claudia, Putra, Juan, Sharma, Deepika, Guthery, Stephen, Rutherford, Ann, Lowichik, Amy, Book, Linda, Meyers, Rebecka, Hall, Tyler, Wang, Kasper, Thomas, Danny, Goodhue, Catherine, Wang, Larry, Soufi, Nisreen, Thomas, Daniel, Karpen, Saul, Romero, Rene, Tory, Rita, Abramowsky, Carlos, McFall, Jeanette, Shneider, Benjamin, Harpavat, Sanjiv, Leung, Daniel, Tessier, Mary, Schady, Deborah, Olvera, Diego, Banks, Christina, Thompson, Richard, Doo, Edward, Hoofnagle, Jay, Sherker, Averell, Hall, Sherry, Merion, Robert, Spino, Cathie, Ye, Wen
Published in Hepatology (Baltimore, Md.) (01.09.2022)
Published in Hepatology (Baltimore, Md.) (01.09.2022)
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Journal Article
Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease
Leung, Daniel H, Devaraj, Sridevi, Goodrich, Nathan P, Chen, Xinpu, Rajapakshe, Deepthi, Ye, Wen, Andreev, Victor, Minard, Charles G, Guffey, Danielle, Molleston, Jean P, Bass, Lee M, Karpen, Saul J, Kamath, Binita M, Wang, Kasper S, Sundaram, Shikha S, Rosenthal, Philip, McKiernan, Patrick, Loomes, Kathleen M, Jensen, M Kyle, Horslen, Simon P, Bezerra, Jorge A, Magee, John C, Merion, Robert M, Sokol, Ronald J, Shneider, Benjamin L, Alonso, Estella, Bass, Lee, Kelly, Susan, Riordan, Mary, Melin-Aldana, Hector, Bezerra, Jorge, Bove, Kevin, Heubi, James, Miethke, Alexander, Tiao, Greg, Denlinger, Julie, Chapman, Erin, Sokol, Ronald, Feldman, Amy, Mack, Cara, Narkewicz, Michael, Suchy, Frederick, Sundaram, Shikha S, Van Hove, Johan, Garcia, Benigno, Kauma, Mikaela, Kocher, Kendra, Steinbeiss, Matthew, Lovell, Mark, Loomes, Kathleen M, Piccoli, David, Rand, Elizabeth, Russo, Pierre, Spinner, Nancy, Erlichman, Jessi, Stalford, Samantha, Pakstis, Dina, King, Sakya, Squires, Robert, Sindhi, Rakesh, Venkat, Veena, Bukauskas, Kathy, McKiernan, Patrick, Haberstroh, Lori, Squires, James, Rosenthal, Philip, Bull, Laura, Curry, Joanna, Langlois, Camille, Kim, Grace, Teckman, Jeffery, Kociela, Vikki, Nagy, Rosemary, Patel, Shraddha, Cerkoski, Jacqueline, Molleston, Jean P, Bozic, Molly, Subbarao, Girish, Klipsch, Ann, Sawyers, Cindy, Cummings, Oscar, Horslen, Simon P, Murray, Karen, Hsu, Evelyn, Cooper, Kara, Young, Melissa, Finn, Laura, Kamath, Binita M, Ng, Vicky, Quammie, Claudia, Putra, Juan, Sharma, Deepika, Parmar, Aishwarya, Guthery, Stephen, Jensen, Kyle, Rutherford, Ann, Lowichik, Amy, Book, Linda, Meyers, Rebecka, Hall, Tyler
Published in Hepatology (Baltimore, Md.) (01.02.2023)
Published in Hepatology (Baltimore, Md.) (01.02.2023)
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Journal Article
The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B
Johnson Valiente, Alexandra, Liem, Kin Seng, Schwarz, Kathleen B, Rosenthal, Philip, Murray, Karen F, Mogul, Douglas, Teckman, Jeffery, Rodriguez-Baez, Norberto, Schwarzenberg, Sarah Jane, Feld, Jordan J, Wong, David K, Lewis-Ximenez, Lia L, Lauer, Georg, Hansen, Bettina E, Ling, Simon C, Janssen, Harry L A, Gehring, Adam J
Published in The Journal of infectious diseases (01.02.2022)
Published in The Journal of infectious diseases (01.02.2022)
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Journal Article
Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hypertension
Teckman, Jeffrey, Rosenthal, Philip, Hawthorne, Kieran, Spino, Cathie, Bass, Lee M., Kerkar, Nanda, Magee, John C., Karpen, Saul, Heubi, James E., Molleston, Jean P., Kamath, Binita M., Guthery, Stephen L., Sherker, Averell H., Alonso, Estella, Bass, Lee, Kelly, Susan, Melin-Aldana, Hector, Bove, Kevin, Heubi, James, Miethke, Alexander, Tiao, Greg, Denlinger, Julie, Chapman, Erin, Feldman, Amy, Narkewicz, Michael, Suchy, Frederick, Sundaram, Shikha, Van Hove, Johan, Garcia, Benigno, Kauma, Mikaela, Kocher, Kendra, Steinbeiss, Matthew, Lovell, Mark, Rand, Elizabeth, Russo, Pierre, Erlichman, Jessi, Pakstis, Dina, King, Sakya, Squires, Robert, Sindhi, Rakesh, Venkat, Veena, McKiernan, Patrick, Haberstroh, Lori, Squires, James, Curry, Joanna, Langlois, Camille, Kim, Grace, Teckman, Jeffery, Kociela, Vikki, Nagy, Rosemary, Patel, Shraddha, Cerkoski, Jacqueline, Molleston, Jean P., Bozic, Molly, Subbarao, Girish, Klipsch, Ann, Sawyers, Cindy, Cummings, Oscar, Horslen, Simon, Murray, Karen, Hsu, Evelyn, Cooper, Kara, Young, Melissa, Finn, Laura, Ng, Vicky, Quammie, Claudia, Putra, Juan, Sharma, Deepika, Guthery, Stephen, Rutherford, Ann, Lowichik, Amy, Book, Linda, Meyers, Rebecka, Hall, Tyler, Wang, Kasper, Thomas, Danny, Goodhue, Catherine, Kohli, Rohit, Soufi, Nisreen, Thomas, Daniel, Karpen, Saul, Gupta, Nitika, Tory, Rita, Berauer, John-Paul, Abramowsky, Carlos, McFall, Jeanette, Shneider, Benjamin, Harpavat, Sanjiv, Hertel, Paula, Leung, Daniel, Schady, Deborah, Banks, Christina, Doo, Edward, Hoofnagle, Jay, Sherker, Averell, Hall, Sherry, Magee, John, Merion, Robert, Spino, Cathie, Ye, Wen
Published in The Journal of pediatrics (01.12.2020)
Published in The Journal of pediatrics (01.12.2020)
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Journal Article
Children with Chronic Hepatitis B in the United States and Canada
Schwarz, Kathleen B., MD, Cloonan, Yona Keich, PhD, Ling, Simon C., MD, Murray, Karen F., MD, Rodriguez-Baez, Norberto, MD, Schwarzenberg, Sarah Jane, MD, Teckman, Jeffrey, MD, Ganova-Raeva, Lilia, PhD, Rosenthal, Philip, MD
Published in The Journal of pediatrics (01.12.2015)
Published in The Journal of pediatrics (01.12.2015)
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Journal Article
Using antisense technology to develop a novel therapy for α-1 antitrypsin deficient (AATD) liver disease and to model AATD lung disease
Guo, Shuling, Booten, Sheri L, Watt, Andrew, Alvarado, Luis, Freier, Susan M, Teckman, Jeffery H, McCaleb, Michael L, Monia, Brett P
Published in Rare diseases (Austin, Tex.) (2014)
Published in Rare diseases (Austin, Tex.) (2014)
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Journal Article
Abstracts8th Annual Meeting of the Oligonucleotide Therapeutics SocietyBoston, MassachusettsOctober 28–31, 2012
Sharp, Phillip A., Maraganore, John, Crooke, Stanley T., Babar, Imran, Janowski, Bethany A., Matsui, Masayuki, Zhang, Huiying, Gagnon, Keith, Shaikh, Sarfraz, Meister, Gunter, Hirsch, Markus, Juliano, Rudy, Fisher, Michael, MacRae, Ian, Butora, Gabor, Matsuda, Akira, Minakawa, Noriaki, Tuschl, Thomas, Williams, Zev, Renwick, Neil, Hafner, Markus, Jiang, Tian, Dela-Moss, Indee, Kierzek, Ryszard, Kierzek, Elzbieta, Ellington, Andy, Seth, Punit, Peng, Chang Geng, Chan, Amy, Charisse, Klaus, Maier, Martin, Fitzgerald, Kevin, Jadhav, Vasant, Jayaraman, Muthusamy, Landesman, Yosef, Zhang, Xuemei, Hutabarat, Renta, Kumar, Varun, Rajeev, Kallanthottathil G., Mui, Barbara L., Du, Xinyao, Hope, Michael J., Madden, Thomas D., Cullis, Pieter, Akinc, Akin, Lewis, David, Hossbach, Markus, Chu, Qili, Klein, Jason J., Wakefield, Darren H., Oropeza, Claudia E., Roehl, Ingo, Vornlocher, Hans-Peter, Sarnow, Peter, Machlin, Erica, Sagan, Selena, Guo, Shuling, Booten, Sheri L., Hung, Gene, Blomenkamp, Keith, Teckman, Jeffery H., McCaleb, Michael L., Monia, Brett P., Akinc, Akin, Sehgal, Alfica, Brodsky, Josh, Qin, June, Foster, Don, Mirkin, Chad, Mitrpant, Charlermchai, McGovern, Vicki, Bevan, Adam, Thornton, Charles, Wheeler, Thurman M., Leger, Andrew J., Pandey, Sanjay K., Wentworth, Bruce M., Lieberman, J., Wheeler, LA, Basar, E, Seung, E, Deruaz, M, Luster, AD, Tager, AM, Patick, Amy, Tessier, Yann, Perssonv, Robert, Sandberg, Bente C., Nochur, Sara, Ftizgerlad, Kevin, Gollob, Jared, Monia, Brett, Müller, Philipp, Jensen, Jeff J., Henry, Scott P., Levin, Art, Lindow, Morten, Lawrence, Christine, Sciabola, Simone, Rotstein, Sergio
Published in Nucleic acid therapeutics (01.12.2012)
Published in Nucleic acid therapeutics (01.12.2012)
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Journal Article
Alpha-1 Antitrypsin Antisense Oligonucleotide Modulates Protease-Antiprotease Imbalance without Further Aggravating Smoke-induced Lung Injury
Xiao, Rui, Stearns, Kyle, Zelonina, Tina, Goldklang, Monica P, Blomenkamp, Keith, Teckman, Jeffery, D'armiento, Jeanine M
Published in bioRxiv (30.07.2019)
Published in bioRxiv (30.07.2019)
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