The role of cellular senescence in ageing and endocrine disease
Khosla, Sundeep, Farr, Joshua N., Tchkonia, Tamara, Kirkland, James L.
Published in Nature reviews. Endocrinology (01.05.2020)
Published in Nature reviews. Endocrinology (01.05.2020)
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Journal Article
The Clinical Potential of Senolytic Drugs
Kirkland, James L., Tchkonia, Tamara, Zhu, Yi, Niedernhofer, Laura J., Robbins, Paul D.
Published in Journal of the American Geriatrics Society (JAGS) (01.10.2017)
Published in Journal of the American Geriatrics Society (JAGS) (01.10.2017)
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Journal Article
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
Iske, Jasper, Seyda, Midas, Heinbokel, Timm, Maenosono, Ryoichi, Minami, Koichiro, Nian, Yeqi, Quante, Markus, Falk, Christine S., Azuma, Haruhito, Martin, Friederike, Passos, João F., Niemann, Claus U., Tchkonia, Tamara, Kirkland, James L., Elkhal, Abdallah, Tullius, Stefan G.
Published in Nature communications (27.08.2020)
Published in Nature communications (27.08.2020)
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Journal Article
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Saul, Dominik, Kosinsky, Robyn Laura, Atkinson, Elizabeth J., Doolittle, Madison L., Zhang, Xu, LeBrasseur, Nathan K., Pignolo, Robert J., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Jurk, Diana, Passos, João F., Hickson, LaTonya J., Xue, Ailing, Monroe, David G., Tchkonia, Tamara, Kirkland, James L., Farr, Joshua N., Khosla, Sundeep
Published in Nature communications (16.08.2022)
Published in Nature communications (16.08.2022)
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Journal Article
Identification of HSP90 inhibitors as a novel class of senolytics
Fuhrmann-Stroissnigg, Heike, Ling, Yuan Yuan, Zhao, Jing, McGowan, Sara J., Zhu, Yi, Brooks, Robert W., Grassi, Diego, Gregg, Siobhan Q., Stripay, Jennifer L., Dorronsoro, Akaitz, Corbo, Lana, Tang, Priscilla, Bukata, Christina, Ring, Nadja, Giacca, Mauro, Li, Xuesen, Tchkonia, Tamara, Kirkland, James L., Niedernhofer, Laura J., Robbins, Paul D.
Published in Nature communications (04.09.2017)
Published in Nature communications (04.09.2017)
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Journal Article
Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
Palmer, Allyson K, Tchkonia, Tamara, LeBrasseur, Nathan K, Chini, Eduardo N, Xu, Ming, Kirkland, James L
Published in Diabetes (New York, N.Y.) (01.07.2015)
Published in Diabetes (New York, N.Y.) (01.07.2015)
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Journal Article
Senolytics improve physical function and increase lifespan in old age
Xu, Ming, Pirtskhalava, Tamar, Farr, Joshua N., Weigand, Bettina M., Palmer, Allyson K., Weivoda, Megan M., Inman, Christina L., Ogrodnik, Mikolaj B., Hachfeld, Christine M., Fraser, Daniel G., Onken, Jennifer L., Johnson, Kurt O., Verzosa, Grace C., Langhi, Larissa G. P., Weigl, Moritz, Giorgadze, Nino, LeBrasseur, Nathan K., Miller, Jordan D., Jurk, Diana, Singh, Ravinder J., Allison, David B., Ejima, Keisuke, Hubbard, Gene B., Ikeno, Yuji, Cubro, Hajrunisa, Garovic, Vesna D., Hou, Xiaonan, Weroha, S. John, Robbins, Paul D., Niedernhofer, Laura J., Khosla, Sundeep, Tchkonia, Tamara, Kirkland, James L.
Published in Nature medicine (01.08.2018)
Published in Nature medicine (01.08.2018)
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Journal Article
Cellular senescence mediates fibrotic pulmonary disease
Schafer, Marissa J., White, Thomas A., Iijima, Koji, Haak, Andrew J., Ligresti, Giovanni, Atkinson, Elizabeth J., Oberg, Ann L., Birch, Jodie, Salmonowicz, Hanna, Zhu, Yi, Mazula, Daniel L., Brooks, Robert W., Fuhrmann-Stroissnigg, Heike, Pirtskhalava, Tamar, Prakash, Y. S., Tchkonia, Tamara, Robbins, Paul D., Aubry, Marie Christine, Passos, João F., Kirkland, James L., Tschumperlin, Daniel J., Kita, Hirohito, LeBrasseur, Nathan K.
Published in Nature communications (23.02.2017)
Published in Nature communications (23.02.2017)
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Journal Article
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Xu, Ming, Tchkonia, Tamara, Ding, Husheng, Ogrodnik, Mikolaj, Lubbers, Ellen R., Pirtskhalava, Tamar, White, Thomas A., Johnson, Kurt O., Stout, Michael B., Mezera, Vojtech, Giorgadze, Nino, Jensen, Michael D., LeBrasseur, Nathan K., Kirkland, James L.
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2015)
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Journal Article
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
Zhu, Yi, Tchkonia, Tamara, Fuhrmann‐Stroissnigg, Heike, Dai, Haiming M., Ling, Yuanyuan Y., Stout, Michael B., Pirtskhalava, Tamar, Giorgadze, Nino, Johnson, Kurt O., Giles, Cory B., Wren, Jonathan D., Niedernhofer, Laura J., Robbins, Paul D., Kirkland, James L.
Published in Aging cell (01.06.2016)
Published in Aging cell (01.06.2016)
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Journal Article
Senolytics reduce coronavirus-related mortality in old mice
Camell, Christina D, Yousefzadeh, Matthew J, Zhu, Yi, Prata, Larissa G P Langhi, Huggins, Matthew A, Pierson, Mark, Zhang, Lei, O'Kelly, Ryan D, Pirtskhalava, Tamar, Xun, Pengcheng, Ejima, Keisuke, Xue, Ailing, Tripathi, Utkarsh, Espindola-Netto, Jair Machado, Giorgadze, Nino, Atkinson, Elizabeth J, Inman, Christina L, Johnson, Kurt O, Cholensky, Stephanie H, Carlson, Timothy W, LeBrasseur, Nathan K, Khosla, Sundeep, O'Sullivan, M Gerard, Allison, David B, Jameson, Stephen C, Meves, Alexander, Li, Ming, Prakash, Y S, Chiarella, Sergio E, Hamilton, Sara E, Tchkonia, Tamara, Niedernhofer, Laura J, Kirkland, James L, Robbins, Paul D
Published in Science (16.07.2021)
Published in Science (16.07.2021)
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Web Resource
Identification of Senescent Cells in the Bone Microenvironment
Farr, Joshua N, Fraser, Daniel G, Wang, Haitao, Jaehn, Katharina, Ogrodnik, Mikolaj B, Weivoda, Megan M, Drake, Matthew T, Tchkonia, Tamara, LeBrasseur, Nathan K, Kirkland, James L, Bonewald, Lynda F, Pignolo, Robert J, Monroe, David G, Khosla, Sundeep
Published in Journal of bone and mineral research (01.11.2016)
Published in Journal of bone and mineral research (01.11.2016)
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Journal Article
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
Roos, Carolyn M., Zhang, Bin, Palmer, Allyson K., Ogrodnik, Mikolaj B., Pirtskhalava, Tamar, Thalji, Nassir M., Hagler, Michael, Jurk, Diana, Smith, Leslie A., Casaclang‐Verzosa, Grace, Zhu, Yi, Schafer, Marissa J., Tchkonia, Tamara, Kirkland, James L., Miller, Jordan D.
Published in Aging cell (01.10.2016)
Published in Aging cell (01.10.2016)
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Journal Article
Aged‐senescent cells contribute to impaired heart regeneration
Lewis‐McDougall, Fiona C., Ruchaya, Prashant J., Domenjo‐Vila, Eva, Shin Teoh, Tze, Prata, Larissa, Cottle, Beverley J., Clark, James E., Punjabi, Prakash P., Awad, Wael, Torella, Daniele, Tchkonia, Tamara, Kirkland, James L., Ellison‐Hughes, Georgina M.
Published in Aging cell (01.06.2019)
Published in Aging cell (01.06.2019)
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Journal Article
Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies
Wyld, Lynda, Bellantuono, Ilaria, Tchkonia, Tamara, Morgan, Jenna, Turner, Olivia, Foss, Fiona, George, Jayan, Danson, Sarah, Kirkland, James L.
Published in Cancers (31.07.2020)
Published in Cancers (31.07.2020)
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Journal Article
Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
Song, Shuling, Tchkonia, Tamara, Jiang, Jing, Kirkland, James L., Sun, Yu
Published in Advanced science (01.12.2020)
Published in Advanced science (01.12.2020)
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Journal Article
Fat tissue, aging, and cellular senescence
Tchkonia, Tamara, Morbeck, Dean E., Von Zglinicki, Thomas, Van Deursen, Jan, Lustgarten, Joseph, Scrable, Heidi, Khosla, Sundeep, Jensen, Michael D., Kirkland, James L.
Published in Aging cell (01.10.2010)
Published in Aging cell (01.10.2010)
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Journal Article
Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy
Kim, Seo Rin, Puranik, Amrutesh S, Jiang, Kai, Chen, Xiaojun, Zhu, Xiang-Yang, Taylor, Ian, Khodadadi-Jamayran, Alireza, Lerman, Amir, Hickson, LaTonya J, Childs, Bennett G, Textor, Stephen C, Tchkonia, Tamara, Niewold, Timothy B, Kirkland, James L, Lerman, Lilach O
Published in Journal of the American Society of Nephrology (01.08.2021)
Published in Journal of the American Society of Nephrology (01.08.2021)
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