Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance
Zamek-Gliszczynski, Maciej J, Taub, Mitchell E, Chothe, Paresh P, Chu, Xiaoyan, Giacomini, Kathleen M, Kim, Richard B, Ray, Adrian S, Stocker, Sophie L, Unadkat, Jashvant D, Wittwer, Matthias B, Xia, Cindy, Yee, Sook-Wah, Zhang, Lei, Zhang, Yan
Published in Clinical pharmacology and therapeutics (01.11.2018)
Published in Clinical pharmacology and therapeutics (01.11.2018)
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Journal Article
A Radioactivity-mass Spectrometry Calibration Method Coupled with Biosynthesis to Generate a Metabolite Standard for Enzyme Kinetics Studies
Wang, Ting, Thomas, Cody, Latli, Bachir, Hrapchak, Matt, Taub, Mitchell E.
Published in Journal of pharmaceutical sciences (01.09.2024)
Published in Journal of pharmaceutical sciences (01.09.2024)
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Journal Article
The Use of Transporter Probe Drug Cocktails for the Assessment of Transporter-Based Drug–Drug Interactions in a Clinical Setting—Proposal of a Four Component Transporter Cocktail
Ebner, Thomas, Ishiguro, Naoki, Taub, Mitchell E.
Published in Journal of pharmaceutical sciences (01.09.2015)
Published in Journal of pharmaceutical sciences (01.09.2015)
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Journal Article
Mechanistic Static Model based Prediction of Transporter Substrate Drug-Drug Interactions Utilizing Atorvastatin and Rifampicin
Mitra, Pallabi, Kasliwala, Rumanah, Iboki, Laeticia, Madari, Shilpa, Williams, Zachary, Takahashi, Ryo, Taub, Mitchell E.
Published in Pharmaceutical research (01.12.2023)
Published in Pharmaceutical research (01.12.2023)
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Journal Article
Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine
Wiebe, Sabrina T., Giessmann, Thomas, Hohl, Kathrin, Schmidt-Gerets, Sven, Hauel, Edith, Jambrecina, Alen, Bader, Kerstin, Ishiguro, Naoki, Taub, Mitchell E., Sharma, Ashish, Ebner, Thomas, Mikus, Gerd, Fromm, Martin F., Müller, Fabian, Stopfer, Peter
Published in Clinical pharmacokinetics (01.12.2020)
Published in Clinical pharmacokinetics (01.12.2020)
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Journal Article
Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions
Britz, Hannah, Hanke, Nina, Taub, Mitchell E., Wang, Ting, Prasad, Bhagwat, Fernandez, Éric, Stopfer, Peter, Nock, Valerie, Lehr, Thorsten
Published in Pharmaceutical research (01.12.2020)
Published in Pharmaceutical research (01.12.2020)
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Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design
Lee, Caroline A, O'Connor, Meeghan A, Ritchie, Tasha K, Galetin, Aleksandra, Cook, Jack A, Ragueneau-Majlessi, Isabelle, Ellens, Harma, Feng, Bo, Taub, Mitchell E, Paine, Mary F, Polli, Joseph W, Ware, Joseph A, Zamek-Gliszczynski, Maciej J
Published in Drug metabolism and disposition (01.04.2015)
Published in Drug metabolism and disposition (01.04.2015)
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Evaluation of a novel, primary human hepatocyte tri-culture model, truvivotm, for its ability to predict metabolic clearance of CYP, UGT, and AO substrates
Piekos, Stephanie, Byer-Alcorace, Alexander, Thomas, Cody, Taub, Mitchell
Published in Drug metabolism and pharmacokinetics (01.04.2024)
Published in Drug metabolism and pharmacokinetics (01.04.2024)
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Journal Article
Optimization of a drug transporter probe cocktail: potential screening tool for transporter‐mediated drug–drug interactions
Stopfer, Peter, Giessmann, Thomas, Hohl, Kathrin, Hutzel, Sabine, Schmidt, Sven, Gansser, Dietmar, Ishiguro, Naoki, Taub, Mitchell E., Sharma, Ashish, Ebner, Thomas, Müller, Fabian
Published in British journal of clinical pharmacology (01.09.2018)
Published in British journal of clinical pharmacology (01.09.2018)
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Journal Article
Prediction and Quantification of Hepatic Transporter-Mediated Uptake of Pitavastatin Utilizing a Combination of the Relative Activity Factor Approach and Mechanistic Modeling
Mitra, Pallabi, Weinheimer, Samantha, Michalewicz, Meeghan, Taub, Mitchell E
Published in Drug metabolism and disposition (01.07.2018)
Published in Drug metabolism and disposition (01.07.2018)
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Journal Article
Comparison of Commonly Used and New Methods to Determine Small Molecule Non-Specific Binding to Human Liver Microsomes
Wang, Ting, Whitcher-Johnstone, Andrea, Scaringella, Young_Sun, Keith-Luzzi, Monica, Shao, Juntang, Taub, Mitchell E., Chan, Tom S.
Published in Journal of pharmaceutical sciences (01.07.2024)
Published in Journal of pharmaceutical sciences (01.07.2024)
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Journal Article
Differential Selectivity of Efflux Transporter Inhibitors in Caco-2 and MDCK–MDR1 Monolayers: A Strategy to Assess the Interaction of a New Chemical Entity with P-gp, BCRP, and MRP2
Mease, Kirsten, Sane, Rucha, Podila, Lalitha, Taub, Mitchell E.
Published in Journal of pharmaceutical sciences (01.05.2012)
Published in Journal of pharmaceutical sciences (01.05.2012)
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Journal Article
Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac
Ramsden, Diane, Tweedie, Donald J, Chan, Tom S, Taub, Mitchell E, Li, Yongmei
Published in Drug metabolism and disposition (01.03.2014)
Published in Drug metabolism and disposition (01.03.2014)
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Journal Article
Characterization of Divergent Metabolic Pathways in Elucidating an Unexpected, Slow-Forming, and Long Half-Life Major Metabolite of Iclepertin
Chan, Tom S., Byer-Alcorace, Alexander J., Latli, Bachir, Liu, Pingrong, Maw, Hlaing H., Raymond, Klairynne G., Scaringella, Young-Sun, Teitelbaum, Aaron M., Wang, Ting, Whitcher-Johnstone, Andrea, Taub, Mitchell E.
Published in Pharmaceutical research (01.08.2023)
Published in Pharmaceutical research (01.08.2023)
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Journal Article
Sex‑, Species‑, and Tissue-Specific Metabolism of Empagliflozin in Male Mouse Kidney Forms an Unstable Hemiacetal Metabolite (M466/2) That Degrades to 4‑Hydroxycrotonaldehyde, a Reactive and Cytotoxic Species
Taub, Mitchell E, Ludwig-Schwellinger, Eva, Ishiguro, Naoki, Kishimoto, Wataru, Yu, Hongbin, Wagner, Klaus, Tweedie, Donald
Published in Chemical research in toxicology (20.01.2015)
Published in Chemical research in toxicology (20.01.2015)
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Variability in P-glycoprotein inhibitory potency (IC₅₀) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria
Bentz, Joe, O'Connor, Michael P, Bednarczyk, Dallas, Coleman, Joann, Lee, Caroline, Palm, Johan, Pak, Y Anne, Perloff, Elke S, Reyner, Eric, Balimane, Praveen, Brännström, Marie, Chu, Xiaoyan, Funk, Christoph, Guo, Ailan, Hanna, Imad, Herédi-Szabó, Krisztina, Hillgren, Kate, Li, Libin, Hollnack-Pusch, Evelyn, Jamei, Masoud, Lin, Xuena, Mason, Andrew K, Neuhoff, Sibylle, Patel, Aarti, Podila, Lalitha, Plise, Emile, Rajaraman, Ganesh, Salphati, Laurent, Sands, Eric, Taub, Mitchell E, Taur, Jan-Shiang, Weitz, Dietmar, Wortelboer, Heleen M, Xia, Cindy Q, Xiao, Guangqing, Yabut, Jocelyn, Yamagata, Tetsuo, Zhang, Lei, Ellens, Harma
Published in Drug metabolism and disposition (01.07.2013)
Published in Drug metabolism and disposition (01.07.2013)
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