A mass spectrometry-based proteome map of drug action in lung cancer cell lines
Ruprecht, Benjamin, Di Bernardo, Julie, Wang, Zhao, Mo, Xuan, Ursu, Oleg, Christopher, Matthew, Fernandez, Rafael B., Zheng, Li, Dill, Brian D., Wang, Huijun, Xu, Yuting, Liaw, Andy, Mortison, Jonathan D., Siriwardana, Nirodhini, Andresen, Brian, Glick, Meir, Tata, James R., Kutilek, Victoria, Cornella-Taracido, Ivan, Chi, An
Published in Nature chemical biology (01.10.2020)
Published in Nature chemical biology (01.10.2020)
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Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer
Chang, Wonsuk, Altman, Michael D, Lesburg, Charles A, Perera, Samanthi A, Piesvaux, Jennifer A, Schroeder, Gottfried K, Wyss, Daniel F, Cemerski, Saso, Chen, Yiping, DiNunzio, Edward, Haidle, Andrew M, Ho, Thu, Kariv, Ilona, Knemeyer, Ian, Kopinja, Johnny E, Lacey, Brian M, Laskey, Jason, Lim, Jongwon, Long, Brian J, Ma, Yanhong, Maddess, Matthew L, Pan, Bo-Sheng, Presland, Jeremy P, Spooner, Edward, Steinhuebel, Dietrich, Truong, Quang, Zhang, Zhibo, Fu, Jianmin, Addona, George H, Northrup, Alan B, Parmee, Emma, Tata, James R, Bennett, David Jonathan, Cumming, Jared N, Siu, Tony, Trotter, B. Wesley
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9
Petrilli, Whitney L., Adam, Gregory C., Erdmann, Roman S., Abeywickrema, Pravien, Agnani, Vijayalakshmi, Ai, Xi, Baysarowich, Jen, Byrne, Noel, Caldwell, John P., Chang, Wonsuk, DiNunzio, Edward, Feng, Zhe, Ford, Rachael, Ha, Sookhee, Huang, Yongcheng, Hubbard, Brian, Johnston, Jennifer M., Kavana, Michael, Lisnock, Jean-Marie, Liang, Rui, Lu, Jun, Lu, Zhijian, Meng, Juncai, Orth, Peter, Palyha, Oksana, Parthasarathy, Gopal, Salowe, Scott P., Sharma, Sujata, Shipman, Jennifer, Soisson, Stephen M., Strack, Alison M., Youm, Hyewon, Zhao, Kake, Zink, Deborah L., Zokian, Hratch, Addona, George H., Akinsanya, Karen, Tata, James R., Xiong, Yusheng, Imbriglio, Jason E.
Published in Cell chemical biology (16.01.2020)
Published in Cell chemical biology (16.01.2020)
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Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression
Lauring, Brett, Taggart, Andrew K P, Tata, James R, Dunbar, Richard, Caro, Luzelena, Cheng, Kang, Chin, Jayne, Colletti, Steven L, Cote, Josee, Khalilieh, Sauzanne, Liu, Jiajun, Luo, Wen-Lin, Maclean, Alexandra A, Peterson, Laurence B, Polis, Adam B, Sirah, Waheeda, Wu, Tsuei-Ju, Liu, Xuan, Jin, Lan, Wu, Kenneth, Boatman, P Douglas, Semple, Graeme, Behan, Dominic P, Connolly, Daniel T, Lai, Eseng, Wagner, John A, Wright, Samuel D, Cuffie, Cynthia, Mitchel, Yale B, Rader, Daniel J, Paolini, John F, Waters, M Gerard, Plump, Andrew
Published in Science translational medicine (22.08.2012)
Published in Science translational medicine (22.08.2012)
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Discovery of a Novel Glucagon Receptor Antagonist N-[(4-{(1S)-1-[3-(3, 5-Dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the Treatment of Type II Diabetes
Xiong, Yusheng, Guo, Jian, Candelore, Mari R, Liang, Rui, Miller, Corey, Dallas-Yang, Qing, Jiang, Guoqiang, McCann, Peggy E, Qureshi, Sajjad A, Tong, Xinchun, Xu, Shiyao Sherrie, Shang, Jackie, Vincent, Stella H, Tota, Laurie M, Wright, Michael J, Yang, Xiaodong, Zhang, Bei B, Tata, James R, Parmee, Emma R
Published in Journal of medicinal chemistry (12.07.2012)
Published in Journal of medicinal chemistry (12.07.2012)
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Publisher Correction: A mass spectrometry-based proteome map of drug action in lung cancer cell lines
Ruprecht, Benjamin, Di Bernardo, Julie, Wang, Zhao, Mo, Xuan, Ursu, Oleg, Christopher, Matthew, Fernandez, Rafael B., Zheng, Li, Dill, Brian D., Wang, Huijun, Xu, Yuting, Liaw, Andy, Mortison, Jonathan D., Siriwardana, Nirodhini, Andresen, Brian, Glick, Meir, Tata, James R., Kutilek, Victoria, Cornella-Taracido, Ivan, Chi, An
Published in Nature chemical biology (01.10.2020)
Published in Nature chemical biology (01.10.2020)
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Journal Article
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9
Petrilli, Whitney L, Adam, Gregory C, Erdmann, Roman S, Abeywickrema, Pravien, Agnani, Vijayalakshmi, Ai, Xi, Baysarowich, Jen, Byrne, Noel, Caldwell, John P, Chang, Wonsuk, DiNunzio, Edward, Feng, Zhe, Ford, Rachael, Ha, Sookhee, Huang, Yongcheng, Hubbard, Brian, Johnston, Jennifer M, Kavana, Michael, Lisnock, Jean-Marie, Liang, Rui, Lu, Jun, Lu, Zhijian, Meng, Juncai, Orth, Peter, Palyha, Oksana, Parthasarathy, Gopal, Salowe, Scott P, Sharma, Sujata, Shipman, Jennifer, Soisson, Stephen M, Strack, AlisonM, Youm, Hyewon, Zhao, Kake, Zink, Deborah L, Zokian, Hratch, Addona, George H, Akinsanya, Karen, Tata, James R, Xiong, Yusheng, Imbriglio, Jason E
Published in Cell chemical biology (18.02.2021)
Published in Cell chemical biology (18.02.2021)
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Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects
Lombardo, Matthew, Bender, Kate, London, Clare, Plotkin, Michael A., Kirkland, Melissa, Mane, Joel, Pachanski, Michele, Geissler, Wayne, Cummings, John, Habulihaz, Bahanu, Akiyama, Taro E., Di Salvo, Jerry, Madeira, Maria, Pols, Joanna, Powles, Mary Ann, Finley, Michael F., Johnson, Eric, Roussel, Thomas, Uebele, Victor N., Crespo, Alejandro, Leung, Dennis, Alleyne, Candice, Trusca, Dorina, Lei, Ying, Howard, Andrew D., Ujjainwalla, Feroze, Tata, James R., Sinz, Christopher J.
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
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Design, Synthesis, and Evaluation of Novel and Selective G‑protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists
Cox, Jason M, Chu, Hong D, Chelliah, Mariappan V, Debenham, John S, Eagen, Keith, Lan, Ping, Lombardo, Matthew, London, Clare, Plotkin, Michael A, Shah, Unmesh, Sun, Zhongxiang, Vaccaro, Henry M, Venkatraman, Srikanth, Suzuki, Takao, Wang, Nengxue, Ashley, Eric R, Crespo, Alejandro, Madeira, Maria, Leung, Dennis H, Alleyne, Candice, Ogawa, Aimie M, Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam, Kirkland, Melissa, Pachanski, Michele, Powles, Mary Ann, Tozzo, Effie, Akiyama, Taro E, Ujjainwalla, Feroze, Tata, James R, Sinz, Christopher J
Published in ACS medicinal chemistry letters (12.01.2017)
Published in ACS medicinal chemistry letters (12.01.2017)
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A novel series of indazole-/indole-based glucagon receptor antagonists
Lin, Songnian, Zhang, Fengqi, Jiang, Guoqiang, Qureshi, Sajjad A., Yang, Xiaodong, Chicchi, Gary G., Tota, Laurie, Bansal, Alka, Brady, Edward, Trujillo, Maria, Salituro, Gino, Miller, Corey, Tata, James R., Zhang, Bei B., Parmee, Emma R.
Published in Bioorganic & medicinal chemistry letters (01.10.2015)
Published in Bioorganic & medicinal chemistry letters (01.10.2015)
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(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans
Boatman, P. Douglas, Lauring, Brett, Schrader, Thomas O, Kasem, Michelle, Johnson, Benjamin R, Skinner, Philip, Jung, Jae-Kyu, Xu, Jerry, Cherrier, Martin C, Webb, Peter J, Semple, Graeme, Sage, Carleton R, Knudsen, Jens, Chen, Ruoping, Luo, Wen-Lin, Caro, Luzelena, Cote, Josee, Lai, Eseng, Wagner, John, Taggart, Andrew K, Carballo-Jane, Ester, Hammond, Milton, Colletti, Steven L, Tata, James R, Connolly, Daniel T, Waters, M. Gerard, Richman, Jeremy G
Published in Journal of medicinal chemistry (26.04.2012)
Published in Journal of medicinal chemistry (26.04.2012)
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3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in Mice
Semple, Graeme, Skinner, Philip J, Gharbaoui, Tawfik, Shin, Young-Jun, Jung, Jae-Kyu, Cherrier, Martin C, Webb, Peter J, Tamura, Susan Y, Boatman, P. Douglas, Sage, Carleton R, Schrader, Thomas O, Chen, Ruoping, Colletti, Steven L, Tata, James R, Waters, M. Gerard, Cheng, Kang, Taggart, Andrew K, Cai, Tian-Quan, Carballo-Jane, Ester, Behan, Dominic P, Connolly, Daniel T, Richman, Jeremy G
Published in Journal of medicinal chemistry (28.08.2008)
Published in Journal of medicinal chemistry (28.08.2008)
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Synthesis and biological evaluation of platensimycin analogs
SHEN, Hong C, DING, Fa-Xiang, TATA, James R, HAMMOND, Milton L, MACCOSS, Malcolm, COLLETTI, Steven L, SINGH, Sheo B, PARTHASARATHY, Gopalakrishnan, SOISSON, Stephen M, HA, Sookhee N, XUN CHEN, KODALI, Srinivas, JUN WANG, DORSO, Karen
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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Discovery of Novel Tricyclic Full Agonists for the G-Protein-Coupled Niacin Receptor 109A with Minimized Flushing in Rats
Shen, Hong C, Ding, Fa-Xiang, Deng, Qiaolin, Wilsie, Larissa C, Krsmanovic, Mihajlo L, Taggart, Andrew K, Carballo-Jane, Ester, Ren, Ning, Cai, Tian-Quan, Wu, Tsuei-Ju, Wu, Kenneth K, Cheng, Kang, Chen, Qing, Wolff, Michael S, Tong, Xinchun, Holt, Tom G, Waters, M. Gerard, Hammond, Milton L, Tata, James R, Colletti, Steven L
Published in Journal of medicinal chemistry (23.04.2009)
Published in Journal of medicinal chemistry (23.04.2009)
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Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension
Petrilli, Whitney L, Hoyt, Scott B, London, Clare, McMasters, Daniel, Verras, Andreas, Struthers, Mary, Cully, Doris, Wisniewski, Thomas, Ren, Ning, Bopp, Charlene, Sok, Andrea, Chen, Qing, Li, Ying, Tung, Elaine, Tang, Wei, Salituro, Gino, Knemeyer, Ian, Karanam, Bindhu, Clemas, Joseph, Zhou, Gaochao, Gibson, Jack, Shipley, Carrie Ann, MacNeil, Douglas J, Duffy, Ruth, Tata, James R, Ujjainwalla, Feroze, Ali, Amjad, Xiong, Yusheng
Published in ACS medicinal chemistry letters (12.01.2017)
Published in ACS medicinal chemistry letters (12.01.2017)
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Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors
Shen, Hong C., Ding, Fa-Xiang, Wang, Siyi, Xu, Suoyu, Chen, Hsuan-shen, Tong, Xinchun, Tong, Vincent, Mitra, Kaushik, Kumar, Sanjeev, Zhang, Xiaoping, Chen, Yuli, Zhou, Gaochao, Pai, Lee-Yuh, Alonso-Galicia, Magdalena, Chen, Xiaoli, Zhang, Bei, Tata, James R., Berger, Joel P., Colletti, Steven L.
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
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Discovery of a Biaryl Cyclohexene Carboxylic Acid (MK-6892): A Potent and Selective High Affinity Niacin Receptor Full Agonist with Reduced Flushing Profiles in Animals as a Preclinical Candidate
Shen, Hong C, Ding, Fa-Xiang, Raghavan, Subharekha, Deng, Qiaolin, Luell, Silvi, Forrest, Michael J, Carballo-Jane, Ester, Wilsie, Larissa C, Krsmanovic, Mihajlo L, Taggart, Andrew K, Wu, Kenneth K, Wu, Tsuei-Ju, Cheng, Kang, Ren, Ning, Cai, Tian-Quan, Chen, Qing, Wang, Junying, Wolff, Michael S, Tong, Xinchun, Holt, Tom G, Waters, M. Gerard, Hammond, Milton L, Tata, James R, Colletti, Steven L
Published in Journal of medicinal chemistry (25.03.2010)
Published in Journal of medicinal chemistry (25.03.2010)
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The First Stereoselective Total Synthesis of Quinine
Stork, Gilbert, Niu, Deqiang, Fujimoto, A, Koft, Emil R, Balkovec, James M, Tata, James R, Dake, Gregory R
Published in Journal of the American Chemical Society (11.04.2001)
Published in Journal of the American Chemical Society (11.04.2001)
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Corrigendum to “Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects” [Bioorg. Med. Chem. Lett. 26 (2016) 5724–5728]
Lombardo, Matthew, Bender, Kate, London, Clare, Plotkin, Michael A., Kirkland, Melissa, Mane, Joel, Pachanski, Michele, Geissler, Wayne, Cummings, John, Habulihaz, Bahanu, Akiyama, Taro E., Di Salvo, Jerry, Madeira, Maria, Pols, Joanna, Powles, Mary Ann, Finley, Michael F., Johnson, Eric, Roussel, Thomas, Uebele, Victor N., Crespo, Alejandro, Leung, Dennis, Alleyne, Candice, Trusca, Dorina, Lei, Ying, Howard, Andrew D., Ujjainwalla, Feroze, Tata, James R., Sinz, Christopher J.
Published in Bioorganic & medicinal chemistry letters (01.03.2017)
Published in Bioorganic & medicinal chemistry letters (01.03.2017)
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Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core
Shen, Dong-Ming, Brady, Edward J., Candelore, Mari R., Dallas-Yang, Qing, Ding, Victor D.-H., Feeney, William P., Jiang, Guoquiang, McCann, Margaret E., Mock, Steve, Qureshi, Sajjad A., Saperstein, Richard, Shen, Xiaolan, Tong, Xinchun, Tota, Laurie M., Wright, Michael J., Yang, Xiaodong, Zheng, Song, Chapman, Kevin T., Zhang, Bei B., Tata, James R., Parmee, Emma R.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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