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The Acyclic CB1R Inverse Agonist Taranabant Mediates Weight Loss by Increasing Energy Expenditure and Decreasing Caloric Intake
Addy, Carol, Wright, Hamish, Van Laere, Koen, Gantz, Ira, Erondu, Ngozi, Musser, Bret J., Lu, Kaifeng, Yuan, Jinyu, Sanabria-Bohórquez, Sandra M., Stoch, Aubrey, Stevens, Cathy, Fong, Tung M., De Lepeleire, Inge, Cilissen, Caroline, Cote, Josee, Rosko, Kim, Gendrano, Isaias N., Nguyen, Allison Martin, Gumbiner, Barry, Rothenberg, Paul, de Hoon, Jan, Bormans, Guy, Depré, Marleen, Eng, Wai-si, Ravussin, Eric, Klein, Samuel, Blundell, John, Herman, Gary A., Burns, H. Donald, Hargreaves, Richard J., Wagner, John, Gottesdiener, Keith, Amatruda, John M., Heymsfield, Steven B.
Published in Cell metabolism (01.01.2008)
Published in Cell metabolism (01.01.2008)
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clinical trial assessing the safety and efficacy of the CB1R inverse agonist taranabant in obese and overweight patients: low-dose study
Proietto, J, Rissanen, A, Harp, J.B, Erondu, N, Yu, Q, Suryawanshi, S, Jones, M.E, Johnson-Levonas, A.O, Heymsfield, S.B, Kaufman, K.D, Amatruda, J.M
Published in International Journal of Obesity (01.08.2010)
Published in International Journal of Obesity (01.08.2010)
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A clinical trial assessing the safety and efficacy of taranabant, a CB1R inverse agonist, in obese and overweight patients: a high-dose study
Aronne, L J, Tonstad, S, Moreno, M, Gantz, I, Erondu, N, Suryawanshi, S, Molony, C, Sieberts, S, Nayee, J, Meehan, A G, Shapiro, D, Heymsfield, S B, Kaufman, K D, Amatruda, J M
Published in International Journal of Obesity (01.05.2010)
Published in International Journal of Obesity (01.05.2010)
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Multiple-dose pharmacokinetics, pharmacodynamics, and safety of taranabant, a novel selective cannabinoid-1 receptor inverse agonist, in healthy male volunteers
Addy, Carol, Rothenberg, Paul, Li, Susie, Majumdar, Anup, Agrawal, Nancy, Li, Hankun, Zhong, Ling, Yuan, Jinyu, Maes, Andrea, Dunbar, Stephanie, Cote, Josee, Rosko, Kim, Van Dyck, Kristien, De Lepeleire, Inge, de Hoon, Jan, Van Hecken, Anne, Depré, Marleen, Knops, Annemie, Gottesdiener, Keith, Stoch, Aubrey, Wagner, John
Published in Journal of clinical pharmacology (01.06.2008)
Published in Journal of clinical pharmacology (01.06.2008)
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Metabolism and excretion of [14C]taranabant, a cannabinoid-1 inverse agonist, in humans
Karanam, Bindhu, Addy, Carol, Bateman, Thomas, Reddy, Vijay Bhasker, Li, Susie, Dean, Dennis, Li, Hankun, Jones, Allen, Schenk, David, Zhang, Andy Shiqiang, Braun, Matt, Freeman, Amanda, Flach, Stephen, Stoch, Aubrey, Chodakewitz, Jeff, Wagner, John A., Kumar, Sanjeev
Published in Xenobiotica (01.10.2010)
Published in Xenobiotica (01.10.2010)
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Development of a Population Pharmacokinetic Model for Taranabant, a Cannibinoid-1 Receptor Inverse Agonist
Li, Xiujiang (Susie), Nielsen, Jace, Cirincione, Brenda, Li, Hankun, Addy, Carol, Wagner, John, Hartford, Alan, Erondu, Ngozi, Gantz, Ira, Morgan, Jerry, Stone, Julie
Published in The AAPS journal (01.12.2010)
Published in The AAPS journal (01.12.2010)
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Pharmacokinetics of digoxin in healthy subjects receiving taranabant, a novel cannabinoid-1 receptor inverse agonist
Denker, Andrew E., Morelli, Gaetano, Vessey, Laura K., Li, Susie, Yuan, Jinyu, Dunbar, Stephanie, Lewis, Nicole M., Taggart, William, Wagner, John A.
Published in Advances in therapy (01.02.2009)
Published in Advances in therapy (01.02.2009)
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Influence of taranabant, a cannabinoid-1 receptor inverse agonist, on pharmacokinetics and pharmacodynamics of warfarin
Schwartz, Jules I., Dunbar, Stephanie, Yuan, Jinyu, Li, Susie, Gipson, Adrianna, Rosko, Kim, Johnson-Levonas, Amy O., Lasseter, Kenneth C., Addy, Carol, Stoch, Aubrey S., Wagner, John A.
Published in Advances in therapy (01.11.2008)
Published in Advances in therapy (01.11.2008)
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Metabolism and excretion of 14Ctaranabant, a cannabinoid-1 inverse agonist, in humans
Karanam, Bindhu, Addy, Carol, Bateman, Thomas, Reddy, Vijay Bhasker, Li, Susie, Dean, Dennis, Li, Hankun, Jones, Allen, Schenk, David, Zhang, Andy Shiqiang, Braun, Matt, Freeman, Amanda, Flach, Stephen, Stoch, Aubrey, Chodakewitz, Jeff, Wagner, John A, Kumar, Sanjeev
Published in Xenobiotica (01.10.2010)
Published in Xenobiotica (01.10.2010)
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Discovery of N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a Novel Cannabinoid-1 Receptor (CB1R) Inverse Agonist for the Treatment of Obesity
Yan, Lin, Huo, Pei, Debenham, John S, Madsen-Duggan, Christina B, Lao, Julie, Chen, Richard Z, Xiao, Jing Chen, Shen, Chun-Pyn, Stribling, D. Sloan, Shearman, Lauren P, Strack, Alison M, Tsou, Nancy, Ball, Richard G, Wang, Junying, Tong, Xinchun, Bateman, Thomas J, Reddy, Vijay B. G, Fong, Tung M, Hale, Jeffrey J
Published in Journal of medicinal chemistry (27.05.2010)
Published in Journal of medicinal chemistry (27.05.2010)
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