Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man
Gotter, Anthony L., Forman, Mark S., Harrell, Charles M., Stevens, Joanne, Svetnik, Vladimir, Yee, Ka Lai, Li, Xiaodong, Roecker, Anthony J., Fox, Steven V., Tannenbaum, Pamela L., Garson, Susan L., Lepeleire, Inge De, Calder, Nicole, Rosen, Laura, Struyk, Arie, Coleman, Paul J., Herring, W. Joseph, Renger, John J., Winrow, Christopher J.
Published in Scientific reports (03.06.2016)
Published in Scientific reports (03.06.2016)
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Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys
Tannenbaum, Pamela L, Tye, Spencer J, Stevens, Joanne, Gotter, Anthony L, Fox, Steven V, Savitz, Alan T, Coleman, Paul J, Uslaner, Jason M, Kuduk, Scott D, Hargreaves, Richard, Winrow, Christopher J, Renger, John J
Published in Sleep (New York, N.Y.) (01.03.2016)
Published in Sleep (New York, N.Y.) (01.03.2016)
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Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia
Winrow, Christopher J., Gotter, Anthony L., Cox, Christopher D., Tannenbaum, Pamela L., Garson, Susan L., Doran, Scott M., Breslin, Michael J., Schreier, John D., Fox, Steven V., Harrell, Charles M., Stevens, Joanne, Reiss, Duane R., Cui, Donghui, Coleman, Paul J., Renger, John J.
Published in Neuropharmacology (01.02.2012)
Published in Neuropharmacology (01.02.2012)
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Journal Article
Promotion of Sleep by Suvorexant-A Novel Dual Orexin Receptor Antagonist
Winrow, Christopher J., Gotter, Anthony L., Cox, Christopher D., Doran, Scott M., Tannenbaum, Pamela L., Breslin, Michael J., Garson, Susan L., Fox, Steven V., Harrell, Charles M., Stevens, Joanne, Reiss, Duane R., Cui, Donghui, Coleman, Paul J., Renger, John J.
Published in Journal of neurogenetics (01.03.2011)
Published in Journal of neurogenetics (01.03.2011)
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Journal Article
The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold
Gotter, Anthony L, Winrow, Christopher J, Brunner, Joseph, Garson, Susan L, Fox, Steven V, Binns, Jacquelyn, Harrell, Charles M, Cui, Donghui, Yee, Ka Lai, Stiteler, Mark, Stevens, Joanne, Savitz, Alan, Tannenbaum, Pamela L, Tye, Spencer J, McDonald, Terrence, Yao, Leon, Kuduk, Scott D, Uslaner, Jason, Coleman, Paul J, Renger, John J
Published in BMC neuroscience (28.08.2013)
Published in BMC neuroscience (28.08.2013)
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Discovery of 5′′-Chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2′:5′,3′′-terpyridine-3′-carboxamide (MK-1064): A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia
Roecker, Anthony J., Mercer, Swati P., Schreier, John D., Cox, Christopher D., Fraley, Mark E., Steen, Justin T., Lemaire, Wei, Bruno, Joseph G., Harrell, C. Meacham, Garson, Susan L., Gotter, Anthony L., Fox, Steven V., Stevens, Joanne, Tannenbaum, Pamela L., Prueksaritanont, Thomayant, Cabalu, Tamara D., Cui, Donghui, Stellabott, Joyce, Hartman, George D., Young, Steven D., Winrow, Christopher J., Renger, John J., Coleman, Paul J.
Published in ChemMedChem (01.02.2014)
Published in ChemMedChem (01.02.2014)
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Discovery of MK-3697: A selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia
Roecker, Anthony J., Reger, Thomas S., Mattern, M. Christa, Mercer, Swati P., Bergman, Jeffrey M., Schreier, John D., Cube, Rowena V., Cox, Christopher D., Li, Dansu, Lemaire, Wei, Bruno, Joseph G., Harrell, C. Meacham, Garson, Susan L., Gotter, Anthony L., Fox, Steven V., Stevens, Joanne, Tannenbaum, Pamela L., Prueksaritanont, Thomayant, Cabalu, Tamara D., Cui, Donghui, Stellabott, Joyce, Hartman, George D., Young, Steven D., Winrow, Christopher J., Renger, John J., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (15.10.2014)
Published in Bioorganic & medicinal chemistry letters (15.10.2014)
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Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists
Skudlarek, Jason W., DiMarco, Christina N., Babaoglu, Kerim, Roecker, Anthony J., Bruno, Joseph G., Pausch, Mark A., O'Brien, Julie A., Cabalu, Tamara D., Stevens, Joanne, Brunner, Joseph, Tannenbaum, Pamela L., Wuelfing, W. Peter, Garson, Susan L., Fox, Steven V., Savitz, Alan T., Harrell, Charles M., Gotter, Anthony L., Winrow, Christopher J., Renger, John J., Kuduk, Scott D., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
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Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs
Tannenbaum, Pamela L, Stevens, Joanne, Binns, Jacquelyn, Savitz, Alan T, Garson, Susan L, Fox, Steven V, Coleman, Paul, Kuduk, Scott D, Gotter, Anthony L, Marino, Michael, Tye, Spencer J, Uslaner, Jason M, Winrow, Christopher J, Renger, John J
Published in Frontiers in behavioral neuroscience (16.05.2014)
Published in Frontiers in behavioral neuroscience (16.05.2014)
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Discovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K2P9.1 (TASK-3)
Coburn, Craig A., Luo, Yunfu, Cui, Mingxiang, Wang, Jiabing, Soll, Richard, Dong, Jingchao, Hu, Bin, Lyon, Michael A., Santarelli, Vincent P., Kraus, Richard L., Gregan, Yun, Wang, Yi, Fox, Steven V., Binns, Jacquelyn, Doran, Scott M., Reiss, Duane R., Tannenbaum, Pamela L., Gotter, Anthony L., Meinke, Peter T., Renger, John J.
Published in ChemMedChem (02.01.2012)
Published in ChemMedChem (02.01.2012)
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Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators
Ramirez, Andres D, Gotter, Anthony L, Fox, Steven V, Tannenbaum, Pamela L, Yao, Lihang, Tye, Spencer J, McDonald, Terrence, Brunner, Joseph, Garson, Susan L, Reiss, Duane R, Kuduk, Scott D, Coleman, Paul J, Uslaner, Jason M, Hodgson, Robert, Browne, Susan E, Renger, John J, Winrow, Christopher J
Published in Frontiers in neuroscience (01.01.2013)
Published in Frontiers in neuroscience (01.01.2013)
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Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition
Uslaner, Jason M, Tye, Spencer J, Eddins, Donnie M, Wang, Xiaohai, Fox, Steven V, Savitz, Alan T, Binns, Jacquelyn, Cannon, Christopher E, Garson, Susan L, Yao, Lihang, Hodgson, Robert, Stevens, Joanne, Bowlby, Mark R, Tannenbaum, Pamela L, Brunner, Joseph, Mcdonald, Terrence P, Gotter, Anthony L, Kuduk, Scott D, Coleman, Paul J, Winrow, Christopher J, Renger, John J
Published in Science translational medicine (03.04.2013)
Published in Science translational medicine (03.04.2013)
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Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties
Coleman, Paul J., Schreier, John D., Cox, Christopher D., Breslin, Michael J., Whitman, David B., Bogusky, Michael J., McGaughey, Georgia B., Bednar, Rodney A., Lemaire, Wei, Doran, Scott M., Fox, Steven V., Garson, Susan L., Gotter, Anthony L., Harrell, C. Meacham, Reiss, Duane R., Cabalu, Tamara D., Cui, Donghui, Prueksaritanont, Thomayant, Stevens, Joanne, Tannenbaum, Pamela L., Ball, Richard G., Stellabott, Joyce, Young, Steven D., Hartman, George D., Winrow, Christopher J., Renger, John J.
Published in ChemMedChem (05.03.2012)
Published in ChemMedChem (05.03.2012)
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Journal Article
Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators
Gotter, Anthony L, Garson, Susan L, Stevens, Joanne, Munden, Regina L, Fox, Steven V, Tannenbaum, Pamela L, Yao, Lihang, Kuduk, Scott D, McDonald, Terrence, Uslaner, Jason M, Tye, Spencer J, Coleman, Paul J, Winrow, Christopher J, Renger, John J
Published in BMC neuroscience (22.09.2014)
Published in BMC neuroscience (22.09.2014)
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Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements
Roecker, Anthony J., Mercer, Swati P., Bergman, Jeffrey M., Gilbert, Kevin F., Kuduk, Scott D., Harrell, C. Meacham, Garson, Susan L., Fox, Steven V., Gotter, Anthony L., Tannenbaum, Pamela L., Prueksaritanont, Thomayant, Cabalu, Tamara D., Cui, Donghui, Lemaire, Wei, Winrow, Christopher J., Renger, John J., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
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Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant
Raheem, Izzat T., Breslin, Michael J., Bruno, Joseph, Cabalu, Tamara D., Cooke, Andrew, Cox, Christopher D., Cui, Donghui, Garson, Susan, Gotter, Anthony L., Fox, Steven V., Harrell, C. Meacham, Kuduk, Scott D., Lemaire, Wei, Prueksaritanont, Thomayant, Renger, John J., Stump, Craig, Tannenbaum, Pamela L., Williams, Peter D., Winrow, Christopher J., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties
Kuduk, Scott D., Skudlarek, Jason W., DiMarco, Christina N., Bruno, Joseph G., Pausch, Mark H., O’Brien, Julie A., Cabalu, Tamara D., Stevens, Joanne, Brunner, Joseph, Tannenbaum, Pamela L., Garson, Susan L., Savitz, Alan T., Harrell, Charles M., Gotter, Anthony L., Winrow, Christopher J., Renger, John J., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (15.06.2015)
Published in Bioorganic & medicinal chemistry letters (15.06.2015)
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Journal Article
TASK-3 as a potential antidepressant target
Gotter, Anthony L, Santarelli, Vincent P, Doran, Scott M, Tannenbaum, Pamela L, Kraus, Richard L, Rosahl, Thomas W, Meziane, Hamid, Montial, Marina, Reiss, Duane R, Wessner, Keith, McCampbell, Alexander, Stevens, Joanne, Brunner, Joseph I, Fox, Steven V, Uebele, Victor N, Bayliss, Douglas A, Winrow, Christopher J, Renger, John J
Published in Brain research (06.10.2011)
Published in Brain research (06.10.2011)
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Conditioned sexual arousal in a nonhuman primate
Snowdon, Charles T., Tannenbaum, Pamela L., Schultz-Darken, Nancy J., Ziegler, Toni E., Ferris, Craig F.
Published in Hormones and behavior (01.05.2011)
Published in Hormones and behavior (01.05.2011)
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Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant
Kuduk, Scott D., Skudlarek, Jason W., Di Marco, Christina N., Bruno, Joseph G., Pausch, Mark A., O’Brien, Julie A., Cabalu, Tamara D., Stevens, Joanne, Brunner, Joseph, Tannenbaum, Pamela L., Gotter, Anthony L., Winrow, Christopher J., Renger, John J., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (01.04.2014)
Published in Bioorganic & medicinal chemistry letters (01.04.2014)
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