Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease
Cramer, Paige E., Gentzel, Renee C., Tanis, Keith Q., Vardigan, Joshua, Wang, Yi, Connolly, Brett, Manfre, Philip, Lodge, Kenneth, Renger, John J., Zerbinatti, Celina, Uslaner, Jason M.
Published in Neurobiology of aging (01.04.2018)
Published in Neurobiology of aging (01.04.2018)
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Journal Article
The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease
Cazanave, Sophie, Podtelezhnikov, Alexei, Jensen, Kristian, Seneshaw, Mulugeta, Kumar, Divya P, Min, Hae-Ki, Santhekadur, Prasanna K, Banini, Bubu, Mauro, Adolfo Gabriele, M Oseini, Abdul, Vincent, Robert, Tanis, Keith Q, Webber, Andrea L, Wang, Liangsu, Bedossa, Pierre, Mirshahi, Faridoddin, Sanyal, Arun J
Published in Scientific reports (08.12.2017)
Published in Scientific reports (08.12.2017)
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Journal Article
Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline
Kang, Wen, Podtelezhnikov, Alexei A, Tanis, Keith Q, Pacchione, Stephen, Su, Ming, Bleicher, Kimberly B, Wang, Zhibin, Laws, George M, Griffiths, Thomas G, Kuhls, Matthew C, Chen, Qing, Knemeyer, Ian, Marsh, Donald J, Mitra, Kaushik, Lebron, Jose, Sistare, Frank D
Published in Toxicological sciences (01.09.2020)
Published in Toxicological sciences (01.09.2020)
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Journal Article
Comparative transcriptomics of choroid plexus in Alzheimer's disease, frontotemporal dementia and Huntington's disease: implications for CSF homeostasis
Stopa, Edward G, Tanis, Keith Q, Miller, Miles C, Nikonova, Elena V, Podtelezhnikov, Alexei A, Finney, Eva M, Stone, David J, Camargo, Luiz M, Parker, Lisan, Verma, Ajay, Baird, Andrew, Donahue, John E, Torabi, Tara, Eliceiri, Brian P, Silverberg, Gerald D, Johanson, Conrad E
Published in Fluids and barriers of the CNS (31.05.2018)
Published in Fluids and barriers of the CNS (31.05.2018)
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Journal Article
Human Alzheimer's disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology
Rothman, Sarah M, Tanis, Keith Q, Gandhi, Pallavi, Malkov, Vladislav, Marcus, Jacob, Pearson, Michelle, Stevens, Richard, Gilliland, Jason, Ware, Christopher, Mahadomrongkul, Veeravan, O'Loughlin, Elaine, Zeballos, Gonzalo, Smith, Roger, Howell, Bonnie J, Klappenbach, Joel, Kennedy, Matthew, Mirescu, Christian
Published in Journal of neuroinflammation (06.09.2018)
Published in Journal of neuroinflammation (06.09.2018)
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Journal Article
Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure
Winrow, Christopher J., Tanis, Keith Q., Reiss, Duane R., Rigby, Alison M., Uslaner, Jason M., Uebele, Victor N., Doran, Scott M., Fox, Steven V., Garson, Susan L., Gotter, Anthony L., Levine, David M., Roecker, Anthony J., Coleman, Paul J., Koblan, Kenneth S., Renger, John J.
Published in Neuropharmacology (2010)
Published in Neuropharmacology (2010)
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Journal Article
A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery
Hafey, Michael J, Houle, Robert, Tanis, Keith Q, Knemeyer, Ian, Shang, Jackie, Chen, Qing, Baudy, Andreas, Monroe, James, Sistare, Frank D, Evers, Raymond
Published in Drug metabolism and disposition (01.11.2020)
Published in Drug metabolism and disposition (01.11.2020)
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Journal Article
Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety Liabilities
Podtelezhnikov, Alexei A, Monroe, James J, Aslamkhan, Amy G, Pearson, Kara, Qin, Chunhua, Tamburino, Alex M, Loboda, Andrey P, Glaab, Warren E, Sistare, Frank D, Tanis, Keith Q
Published in Toxicological sciences (01.05.2020)
Published in Toxicological sciences (01.05.2020)
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Journal Article
Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats
Glaab, Warren E, Holder, Daniel, He, Yudong D, Bailey, Wendy J, Gerhold, David L, Beare, Carolann, Erdos, Zoltan, Lane, Pamela, Michna, Laura, Muniappa, Nagaraja, Lawrence, Jeffrey W, Tanis, Keith Q, Sina, Joseph F, Skopek, Thomas R, Sistare, Frank D
Published in Toxicological sciences (01.06.2021)
Published in Toxicological sciences (01.06.2021)
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Journal Article
AhR Activation in Pharmaceutical Development: Applying Liver Gene Expression Biomarker Thresholds to Identify Doses Associated With Tumorigenic Risks in Rats
Qin, Chunhua, Aslamkhan, Amy G, Pearson, Kara, Tanis, Keith Q, Podtelezhnikov, Alexei, Frank, Erika, Pacchione, Stephen, Pippert, Todd, Glaab, Warren E, Sistare, Frank D
Published in Toxicological sciences (01.09.2019)
Published in Toxicological sciences (01.09.2019)
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Journal Article
A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies
Corton, J Christopher, Mitchell, Constance A, Auerbach, Scott, Bushel, Pierre, Ellinger-Ziegelbauer, Heidrun, Escobar, Patricia A, Froetschl, Roland, Harrill, Alison H, Johnson, Kamin, Klaunig, James E, Pandiri, Arun R, Podtelezhnikov, Alexei A, Rager, Julia E, Tanis, Keith Q, van der Laan, Jan Willem, Vespa, Alisa, Yauk, Carole L, Pettit, Syril D, Sistare, Frank D
Published in Toxicological sciences (28.06.2022)
Published in Toxicological sciences (28.06.2022)
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Journal Article
Transcriptional Architecture of the Primate Neocortex
Bernard, Amy, Lubbers, Laura S., Tanis, Keith Q., Luo, Rui, Podtelezhnikov, Alexei A., Finney, Eva M., McWhorter, Mollie M.E., Serikawa, Kyle, Lemon, Tracy, Morgan, Rebecca, Copeland, Catherine, Smith, Kimberly, Cullen, Vivian, Davis-Turak, Jeremy, Lee, Chang-Kyu, Sunkin, Susan M., Loboda, Andrey P., Levine, David M., Stone, David J., Hawrylycz, Michael J., Roberts, Christopher J., Jones, Allan R., Geschwind, Daniel H., Lein, Ed S.
Published in Neuron (Cambridge, Mass.) (22.03.2012)
Published in Neuron (Cambridge, Mass.) (22.03.2012)
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Journal Article
Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury
Monroe, James J, Tanis, Keith Q, Podtelezhnikov, Alexei A, Nguyen, Truyen, Machotka, Sam V, Lynch, Donna, Evers, Raymond, Palamanda, Jairam, Miller, Randy R, Pippert, Todd, Cabalu, Tamara D, Johnson, Timothy E, Aslamkhan, Amy G, Kang, Wen, Tamburino, Alex M, Mitra, Kaushik, Agrawal, Nancy G B, Sistare, Frank D
Published in Toxicological sciences (01.09.2020)
Published in Toxicological sciences (01.09.2020)
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Journal Article
Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation
Arnardottir, Erna S, Nikonova, Elena V, Shockley, Keith R, Podtelezhnikov, Alexei A, Anafi, Ron C, Tanis, Keith Q, Maislin, Greg, Stone, David J, Renger, John J, Winrow, Christopher J, Pack, Allan I
Published in Sleep (New York, N.Y.) (01.10.2014)
Published in Sleep (New York, N.Y.) (01.10.2014)
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Journal Article
Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity
Li, Yutai, Evers, Raymond, Hafey, Michael J, Cheon, Kyeongmi, Duong, Hong, Lynch, Donna, LaFranco-Scheuch, Lisa, Pacchione, Stephen, Tamburino, Alex M, Tanis, Keith Q, Geddes, Kristin, Holder, Daniel, Zhang, Nanyan Rena, Kang, Wen, Gonzalez, Raymond J, Galijatovic-Idrizbegovic, Alema, Pearson, Kara M, Lebron, Jose A, Glaab, Warren E, Sistare, Frank D
Published in Toxicological sciences (01.07.2019)
Published in Toxicological sciences (01.07.2019)
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