Mechanism-Based Inactivation of Cytochrome P450 3A4 by Benzbromarone
Tang, Lloyd Wei Tat, Verma, Ravi Kumar, Fan, Hao, Chan, Eric Chun Yong
Published in Molecular pharmacology (01.04.2021)
Published in Molecular pharmacology (01.04.2021)
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Journal Article
Febuxostat and its major acyl glucuronide metabolite are potent inhibitors of organic anion transporter 3: Implications for drug‐drug interactions with rivaroxaban
Tang, Lloyd Wei Tat, Cheong, Tino Woon Huai, Chan, Eric Chun Yong
Published in Biopharmaceutics & drug disposition (01.04.2022)
Published in Biopharmaceutics & drug disposition (01.04.2022)
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Journal Article
Combination Bacillus Calmette–Guérin and indoleamine 2,3‐dioxygenase 1 inhibitor therapy of murine orthotopic bladder cancer
Lee, Sze Han, Mahendran, Ratha, Tham, Sin Mun, Thamboo, Thomas Paulraj, Kioh, Dorinda Yan Qin, Tang, Lloyd Wei Tat, Chiong, Edmund, Esuvaranathan, Kesavan, Chan, Eric Chun Yong
Published in BJU international (01.11.2020)
Published in BJU international (01.11.2020)
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Journal Article
Tissue-Specific microRNA Expression Profiling to Derive Novel Biomarkers for the Diagnosis and Subtyping of Small B-Cell Lymphomas
Hue, Susan Swee-Shan, Jin, Yu, Cheng, He, Bin Masroni, Muhammad Sufyan, Tang, Lloyd Wei Tat, Ho, Yong Howe, Ong, Diana Bee-Lan, Leong, Sai Mun, Tan, Soo Yong
Published in Cancers (10.01.2023)
Published in Cancers (10.01.2023)
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Journal Article
Identification of Infigratinib as a Potent Reversible Inhibitor and Mechanism-Based Inactivator of CYP2J2: Nascent Evidence for a Potential In Vivo Metabolic Drug-Drug Interaction with Rivaroxaban
Tang, Lloyd Wei Tat, Wu, Guoyi, Chan, Eric Chun Yong
Published in The Journal of pharmacology and experimental therapeutics (01.08.2022)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2022)
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Journal Article
Quantification of the irreversible fibroblast growth factor receptor inhibitor futibatinib by UPLC-MS/MS: Application to the metabolic stability assay in human liver microsomes for the estimation of its in vitro hepatic intrinsic clearance
Tang, Lloyd Wei Tat, Chan, Eric Chun Yong
Published in Journal of pharmaceutical and biomedical analysis (30.05.2022)
Published in Journal of pharmaceutical and biomedical analysis (30.05.2022)
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Journal Article
Probe Substrate Dependencies in CYP3A4 Allosteric Inhibition: A Novel Molecular Mechanism Involving F–F′ Loop Perturbations
Wei, Wan, Tang, Lloyd Wei Tat, Verma, Ravi Kumar, Fan, Hao, Chan, Eric Chun Yong
Published in Journal of chemical information and modeling (25.03.2024)
Published in Journal of chemical information and modeling (25.03.2024)
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Journal Article
Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of CYP3A
Tang, Lloyd Wei Tat, Fu, Jiaxin, Koh, Siew Kwan, Wu, Guoyi, Zhou, Lei, Chan, Eric Chun Yong
Published in Drug metabolism and disposition (01.07.2022)
Published in Drug metabolism and disposition (01.07.2022)
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Journal Article
Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A
Tang, Lloyd Wei Tat, Wei, Wan, Verma, Ravi Kumar, Koh, Siew Kwan, Zhou, Lei, Fan, Hao, Chan, Eric Chun Yong
Published in Drug metabolism and disposition (01.05.2022)
Published in Drug metabolism and disposition (01.05.2022)
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Journal Article
Mechanism-Based Inactivation of Cytochrome P450 3A4 and 3A5 by the Fibroblast Growth Factor Receptor Inhibitor Erdafitinib
Tang, Lloyd Wei Tat, Teng, Jian Wei, Koh, Siew Kwan, Zhou, Lei, Go, Mei Lin, Chan, Eric Chun Yong
Published in Chemical research in toxicology (19.07.2021)
Published in Chemical research in toxicology (19.07.2021)
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Journal Article
Direct and Sequential Bioactivation of Pemigatinib to a Reactive Iminium Ion Intermediate Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A
Tang, Lloyd Wei Tat, Wei, Wan, Verma, Ravi Kumar, Koh, Siew Kwan, Zhou, Lei, Fan, Hao, Chan, Eric Chun Yong
Published in The FASEB journal (01.05.2022)
Published in The FASEB journal (01.05.2022)
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Journal Article
Differential Reversible and Irreversible Interactions between Benzbromarone and Human Cytochrome P450s 3A4 and 3A5
Tang, Lloyd Wei Tat, Verma, Ravi Kumar, Yong, Ren Ping, Li, Xin, Wang, Lili, Lin, Qingsong, Fan, Hao, Chan, Eric Chun Yong
Published in Molecular pharmacology (01.09.2021)
Published in Molecular pharmacology (01.09.2021)
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Journal Article
Characterization and Applications of Permeabilized Hepatocytes in Drug Discovery
Zhang, Sam, Orozco, Christine C., Tang, Lloyd Wei Tat, Racich, Jillian, Carlo, Anthony A., Chang, George, Tess, David, Keefer, Christopher, Di, Li
Published in The AAPS journal (28.03.2024)
Published in The AAPS journal (28.03.2024)
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Journal Article
Characterization of CYP3A5 Selective Inhibitors for Reaction Phenotyping of Drug Candidates
Chen, Jie, Tang, Lloyd Wei Tat, Jordan, Samantha, Harrison, Makayla, Gualtieri, Gabrielle M., DaSilva, Ethan, Morris, Danial, Bora, Gary, Che, Ye, Di, Li
Published in The AAPS journal (16.02.2024)
Published in The AAPS journal (16.02.2024)
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Journal Article
Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes
Liu, Jianhua, Vernikovskaya, Daria, Bora, Gary, Carlo, Anthony, Burchett, Woodrow, Jordan, Samantha, Tang, Lloyd Wei Tat, Yang, Joy, Che, Ye, Chang, George, Troutman, Matthew D., Di, Li
Published in The AAPS journal (28.03.2024)
Published in The AAPS journal (28.03.2024)
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Journal Article